5-hydroxy-valeric acid-(2-hydroxy-ethylamide) | 89855-79-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-hydroxy-valeric acid-(2-hydroxy-ethylamide)
• 英文别名: 5-Hydroxy-valeriansaeure-(2-hydroxy-aethylamid)；N-(2-hydroxyethyl) N-5-hydroxypentanoylamide；N-(2-Hydroxyethyl)-5-hydroxypentanamide；5-hydroxy-N-(2-hydroxyethyl)pentanamide
• CAS: 89855-79-8
• 化学式: C₇H₁₅NO₃
• 分子量: 161.201
• InChiKey: IMUBNGWOLAZKDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-hydroxy-valeric acid-(2-hydroxy-ethylamide) 在 氯化亚砜 、 苯 作用下， 生成 5-chloro-valeric acid-(2-chloro-ethylamide)
  参考文献：
  名称：

  Sidel'kowskaja et al., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1958, p. 1111,1114; engl.Ausg.S.1078,1081

  摘要：

  DOI：
• 作为产物：
  描述：

  delta-戊内酯 、 C.I.酸性橙108 以 甲苯 为溶剂， 反应 1.0h， 以83%的产率得到5-hydroxy-valeric acid-(2-hydroxy-ethylamide)
  参考文献：
  名称：

  酰胺与 β-羟基胺连接中的反应性酯

  摘要：

  轻度活化酯和 1,2-氨基醇之间的酰胺形成不需要偶联试剂。反应途径包括简单的分子间酯交换和分子内 ON 转酰化。该方法是环境友好的，并且通过高度活化的酰化中间体没有外消旋化的风险。

  DOI：

  10.1002/ejoc.201200624

文献信息

• [EN] POLY(KETALS) AND RELATED COMPOSITIONS AND METHODS<br/>[FR] POLYCÉTALS ET COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
  申请人：CHILDREN'S MEDICAL CENTER CORP

  公开号：WO2017189953A1

  公开（公告）日：2017-11-02

  Compositions comprising polymers comprising one or more ketal, monothioketal, and/or thioketal bonds are provided, as well as related methods and kits. In some embodiments, a polymer may comprise one or more repeat units comprising one or more ketal, monothioketal, and/or thioketal bonds and a precursor of a pharmaceutically active agent. The precursor of the pharmaceutically active agent may be located in the backbone or may be a pendant group. The polymer may degrade in certain environments (e.g., aqueous environments, acidic environments, in vivo, etc.) to produce the pharmaceutically active agent and other biocompatible degradation products, such as certain ketones, alcohols, and/or thiols. Regardless of the location of the precursor of the pharmaceutically active agent in the repeat unit(s), the polymer may have a prolonged degradation time and/or release of the pharmaceutically active agent in certain environments. Various compositions, described herein, may be particularly well suited for applications requiring extended release of pharmaceutically active agents, such as the treatment of ophthalmic disorders.

  提供了包含聚合物的组合物，其中聚合物包含一个或多个缩醛基、单硫缩醛基和/或硫缩醛基的键，以及相关方法和试剂盒。在某些实施例中，聚合物可以包含一个或多个重复单元，其中包含一个或多个缩醛基、单硫缩醛基和/或硫缩醛基的键以及药用活性剂的前体。药用活性剂的前体可以位于骨架中或可以是一个挂链基团。聚合物可以在某些环境中降解（例如水性环境、酸性环境、体内等），以产生药用活性剂和其他生物相容性降解产物，例如某些酮类、醇类和/或硫醇。无论药用活性剂的前体在重复单元中的位置如何，聚合物在某些环境中可能具有较长的降解时间和/或释放药用活性剂。本文描述的各种组合物可能特别适用于需要延长释放药用活性剂的应用，例如治疗眼科疾病。
• Poly(ketals) and related compositions and methods
  申请人：Children's Medical Center Corporation

  公开号：US11071714B2

  公开（公告）日：2021-07-27

  Compositions comprising polymers comprising one or more ketal, monothioketal, and/or thioketal bonds are provided, as well as related methods and kits. In some embodiments, a polymer may comprise one or more repeat units comprising one or more ketal, monothioketal, and/or thioketal bonds and a precursor of a pharmaceutically active agent. The precursor of the pharmaceutically active agent may be located in the backbone or may be a pendant group. The polymer may degrade in certain environments (e.g., aqueous environments, acidic environments, in vivo, etc.) to produce the pharmaceutically active agent and other biocompatible degradation products, such as certain ketones, alcohols, and/or thiols. Regardless of the location of the precursor of the pharmaceutically active agent in the repeat unit(s), the polymer may have a prolonged degradation time and/or release of the pharmaceutically active agent in certain environments. Various compositions, described herein, may be particularly well suited for applications requiring extended release of pharmaceutically active agents, such as the treatment of ophthalmic disorders.

  本发明提供了由包含一个或多个酮键、单硫酮键和/或硫酮键的聚合物组成的组合物以及相关方法和试剂盒。在某些实施方案中，聚合物可包含一个或多个由一个或多个酮键、单硫酮键和/或硫酮键组成的重复单元和一种药用活性剂的前体。药用活性剂的前体可以位于骨架中，也可以是一个悬挂基团。聚合物可在特定环境（如水环境、酸性环境、体内等）中降解，产生药用活性剂和其他生物相容性降解产物，如某些酮、醇和/或硫醇。无论药用活性剂前体在重复单元中的位置如何，聚合物在某些环境中都可能会延长降解时间和/或释放药用活性剂。本文所述的各种组合物可能特别适用于需要延长药用活性剂释放时间的应用，如眼科疾病的治疗。
• Taste improving composition
  申请人：Givaudan Nederland Services B.V.

  公开号：EP1854782B1

  公开（公告）日：2009-09-30
• Taste improving substances
  申请人：Visser Jan

  公开号：US20070259089A1

  公开（公告）日：2007-11-08

  The present invention in a first aspect relates to taste improvement of foodstuffs, beverages, tobacco products and oral care products, using a substance according to formula (I), edible salts or edible esters thereof: It was found that substances represented by formula (I) are capable of modifying and complementing, the sensory impact of taste imparting substances. Thus, the present taste improving substances are advantageously applied in flavour compositions, foodstuffs, tobacco products and oral care products. Typical examples of taste improving substances according to the present invention include N-(2-hydroxyethyl) 3-hydroxypropionamide; N-(2-hydroxyethyl) 3-hydroxybutyramide; N-(2-hydroxyethyl) 4-hydroxybutyramide; N-(2-hydroxyethyl) N-5-hydroxypentanoylamide; N-(2-hydroxyethyl) 4-hydroxypentanoylamide; N-(2-hydroxyethyl) 3-hydroxypentanoylamide; N-(2-hydroxyethyl) 2-methyl-4-hydroxy-butyramide; N-(2-hydroxyethyl) 2-methyl-3-hydroxybutyramide; N-(2-hydroxyethyl) N-6-hydroxyhexanoylamide; N-(2-hydroxyethyl) 5-hydroxyhexanoylamide; N-(2-hydroxyethyl) 4-hydroxyhexanoylamide; N-(2-hydroxyethyl) 3-hydroxyhexanoylamide; N-(2-hydroxyethyl) 4-hydroxy-2-keto-3-methyl-pentanoylamide; N-(2-hydroxyethyl) 4-hydroxy-2-keto-3-methyl-hexanoylamide and mixtures thereof.
• Taste Improving Substances
  申请人：Visser Jan

  公开号：US20120328536A1

  公开（公告）日：2012-12-27

  The present invention relates to taste improvement of foodstuffs, beverages, tobacco products and oral care products, using a substance according to formula (I), edible salts or edible esters thereof: It was found that substances represented by formula (I) are capable of modifying and complementing, the sensory impact of taste imparting substances. Thus, the present taste improving substances are advantageously applied in flavour compositions, foodstuffs, tobacco products and oral care products. Typical examples of taste improving substances according to the present invention include N-(2-hydroxyethyl) 3-hydroxypropionamide; N-(2-hydroxyethyl) 3-hydroxybutyramide; N-(2-hydroxyethyl) 4-hydroxybutyramide; N-(2-hydroxyethyl) N-5-hydroxypentanoylamide; N-(2-hydroxyethyl) 4-hydroxypentanoylamide; N-(2-hydroxyethyl) 3-hydroxypentanoylamide; N-(2-hydroxyethyl) 2-methyl-4-hydroxy-butyramide; N-(2-hydroxyethyl) 2-methyl-3-hydroxybutyramide; N-(2-hydroxyethyl) N-6-hydroxyhexanoylamide; N-(2-hydroxyethyl) 5-hydroxyhexanoylamide; N-(2-hydroxyethyl) 4-hydroxyhexanoylamide; N-(2-hydroxyethyl) 3-hydroxyhexanoylamide; N-(2-hydroxyethyl) 4-hydroxy-2-keto-3-methyl-pentanoylamide; N-(2-hydroxyethyl) 4-hydroxy-2-keto-3-methyl-hexanoylamide and mixtures thereof.