The present invention recognizes that the determination of ion transport function or properties using direct detection methods, such as whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and other fluidic components and methods of use that allow for the direct analysis of ion transport function or properties using microfabricated structures that can allow for automated detection of ion transport function or properties. These biochips and fluidic components and methods of use thereof are particularly appropriate for automating the detection of ion transport function or properties, particularly for screening purposes.
本发明认识到,使用直接检测方法(如全细胞记录或单通道记录)确定离子转运功能或特性优于使用间接检测方法(如基于 FRET 的检测系统)的方法。本发明提供了
生物芯片和其他流体元件及使用方法,可利用微加工结构直接分析离子转运功能或特性,从而实现离子转运功能或特性的自动检测。这些
生物芯片和流体元件及其使用方法特别适用于自动检测离子转运功能或特性,尤其是用于筛选目的。