1H-benzo[f]indole-2,3-dione | 5810-96-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1H-benzo[f]indole-2,3-dione
• 英文别名: benzisatin；1H-benz[f]indole-2,3-dione；1H-Benz[f]indol-2,3-dion；1H-Benz[f]indol-2,3-dione；benzo[5,6]isatin
• CAS: 5810-96-8
• 化学式: C₁₂H₇NO₂
• 分子量: 197.193
• InChiKey: XHORCFOVPVATAY-UHFFFAOYSA-N

物化性质

• 密度：
  1.391±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1H-benzo[f]indole-2,3-dione 在 氢氧化钾 、 lead(II) oxide 、 苯 作用下， 生成 benzo[b]acridine-6,11-dione
  参考文献：
  名称：

  Etienne; Staehelin, Bulletin de la Societe Chimique de France, 1954, p. 748,751

  摘要：

  DOI：
• 作为产物：
  描述：

  3-乙酰氧基-1-乙酰基-1H-苯并[f]吲哚 在 盐酸 、 sodium hydroxide 、 水 、 sodium carbonate 作用下， 生成 1H-benzo[f]indole-2,3-dione
  参考文献：
  名称：

  Etienne; Staehelin, Bulletin de la Societe Chimique de France, 1954, p. 748,751

  摘要：

  DOI：

文献信息

• Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids
  作者：Gordon W. Rewcastle、Graham J. Atwell、Li Zhuang、Bruce C. Baguley、William A. Denny

  DOI：10.1021/jm00105a034

  日期：1991.1

  Analogues of 9-oxo-9H-xanthene-4-acetic acid (XAA) bearing small, lipophilic 5-substituents are among the most dose-potent compounds yet reported with the capability of causing hemorrhagic necrosis of implanted colon 38 tumors in mice. To further extend structure-activity relationships among this class of compound, a series of XAA derivatives bearing two small lipophilic groups at various positions

  带有小的，亲脂性的5个取代基的9-氧代9H-氧杂蒽-4-乙酸（XAA）的类似物是迄今已报道的最强剂量化合物，具有引起小鼠植入的结肠38肿瘤出血性坏死的能力。为了进一步扩展这类化合物之间的构效关系，已经制备并评估了一系列在不同位置带有两个小的亲脂基团的XAA衍生物。特别是5，6-二取代的化合物始终显示出高水平的剂量效力和活性，这表明这是取代的9-氧代-9H-氧杂蒽-4-乙酸中的最佳构型。5,6-二甲基和5-甲基-6-甲氧基是最有效的类似物，
• Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same
  申请人：Tzeng Cherng-Chyi

  公开号：US20090111987A1

  公开（公告）日：2009-04-30

  Disclosed herein are novel imino-indeno[1,2-c]quinoline derivatives of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these derivatives, their synthetic precursors and their uses in the manufacture of pharmaceutical compositions for use in the treatment of cancers.

  本文披露了一种新型的imino-indeno[1,2-c]quinoline衍生物，其化学式为(I)：或其药用可接受的盐或溶剂，其中每个取代基的定义如规范和权利要求所述。还披露了这些衍生物的制备过程、它们的合成前体以及它们在制造用于治疗癌症的药物组合物中的用途。
• Long emission wavelength chemiluminescent compounds and their use in
  申请人：Chiron Diagnostics Corporation

  公开号：US05702887A1

  公开（公告）日：1997-12-30

  An assay method incorporating at least two different chemiluminescent compounds for detection and/or quantitation of at least two substances in a test sample is described. The synthesis of chemiluminescent reagents or conjugates for use in such methods as well as kits incorporating such reagents are also disclosed. The assays have particular application in the field of clinical diagnostics.

  本文描述了一种至少包含两种不同化学发光化合物用于检测和/或定量测试样品中至少两种物质的测定方法。还公开了用于这种方法的化学发光试剂或结合物的合成，以及包含这种试剂的试剂盒。这些测定在临床诊断领域具有特别的应用。
• Synthesis of benzo-annulated tryptanthrins and their biological properties
  作者：Jing Lu Liang、So-Eun Park、Youngjoo Kwon、Yurngdong Jahng

  DOI：10.1016/j.bmc.2012.06.034

  日期：2012.8

  A series of benzo-annulated derivatives of tryptanthrin were prepared and their optical and redox properties were studied. Tryptanthrin and its benzo-annulated derivatives showed selective inhibitory activity on topo I with an increase of activity on topo II by benzo-annulation on quinazolin-4(3H)-one moiety. Although the benzo-annulation on quinazolin-4(3H)-one ring did not affect significantly on the inhibitory activities against topo I and II, the benzoannulation on indolin-3-one ring affected the inhibitory activity very much especially by linear annulation. Cytotoxicities were not significantly changed upon benzoannulation, which were not directly related either to the inhibitory activities against topo I and II or to the reduction potentials. (C) 2012 Elsevier Ltd. All rights reserved.
• Mononitration of derivatives of benzisatins
  作者：L. I. Mazhilis、P. B. Terent'ev、V. A. Bolotin

  DOI：10.1007/bf00472618

  日期：1989.1