bis-benzothiazol-2-yl sulfone | 119993-83-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: bis-benzothiazol-2-yl sulfone
• 英文别名: Bis-benzothiazol-2-yl-sulfon；Benzothiazole, 2-(2-benzothiazolylsulfonyl)-；2-(1,3-benzothiazol-2-ylsulfonyl)-1,3-benzothiazole
• CAS: 119993-83-8
• 化学式: C₁₄H₈N₂O₂S₃
• 分子量: 332.428
• InChiKey: AVMBLBCBNFYRMX-UHFFFAOYSA-N

物化性质

• 沸点：
  549.8±33.0 °C(Predicted)
• 密度：
  1.572±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  125
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  双(2-苯并噻唑基)硫化物 在 双氧水 、 溶剂黄146 作用下， 生成 bis-benzothiazol-2-yl sulfone
  参考文献：
  名称：

  Itai; Yamamoto, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1948, vol. 68, p. 128

  摘要：

  DOI：

文献信息

• 3-(Fluorovinyl)pyrazoles and their use
  申请人：HÄRTER Michael

  公开号：US20130150325A1

  公开（公告）日：2013-06-13

  The present application relates to novel 3-(fluorovinyl)pyrazole derivatives, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.

  本申请涉及新颖的3-(氟乙烯基)吡唑衍生物，涉及它们的制备方法，涉及它们用于治疗和/或预防疾病的使用，以及用于制备用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防增殖性和血管生成性疾病以及那些由于对缺氧状态的代谢适应而产生的疾病。此类治疗可以作为单一疗法进行，也可以与其他药物或进一步的治疗措施相结合进行。
• C5 BENZOTHIAZOLYL SULFONE COMPOUND, METHOD OF PREPARING THE SAME, METHOD OF PREPARING POLYENE DIALDEHYDE COMPOUND USING THE SAME, AND METHOD OF SYNTHESIZING LYCOPENE USING THE SAME
  申请人：MYONGJI UNIVERSITY INDUSTRY AND ACADEMIA COOPERATION FOUNDATION

  公开号：US20150376175A1

  公开（公告）日：2015-12-31

  Disclosed are a novel C5 benzothiazolyl sulfone compound having an acetal protecting group, a method of preparing the same, and a method of efficiently preparing an apo-carotene dialdehyde compound having a polyene dialdehyde structure using the same. Also, a method of efficiently preparing lycopene by olefination (Julia-Kocienski) between the apo-carotene dialdehyde compound (C20 crocetin dialdehyde) and C10 benzothiazolyl geranyl sulfone is provided.

  公开了一种具有缩醛保护基的新型C5苯并噻唑基磺酮化合物，其制备方法，以及使用该化合物高效制备具有聚烯二醛结构的apo-类胡萝卜二醛化合物的方法。此外，还提供了一种通过apo-类胡萝卜二醛化合物（C20红花素二醛）与C10苯并噻唑基戈壳烯基磺酮之间的烯烃化（朱利亚-科琴斯基反应）高效制备番茄红素的方法。
• [EN] VITAMIN D3 DERIVATIVES AND PHARMACEUTICAL USE THEREOF<br/>[FR] DÉRIVÉS DE LA VITAMINE D3 ET LEUR UTILISATION PHARMACEUTIQUE
  申请人：UNIV KYOTO

  公开号：WO2016103722A1

  公开（公告）日：2016-06-30

  The present invention relates to vitamin D3 derivatives of the following formula, wherein each symbol has the same meaning as defined herein, and pharmaceutical or medical use thereof for treating metabolic disease, liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

  本发明涉及以下式的维生素D3衍生物，其中每个符号具有本文所定义的相同含义，并且用于治疗代谢疾病、肝病、肥胖症、糖尿病、心血管疾病或癌症患者的药用或医用。
• PROCESS FOR THE PREPARATION OF CALCIPOTRIOL
  申请人：KUTNER Andrzej

  公开号：US20100222614A1

  公开（公告）日：2010-09-02

  A process for the preparation of calcipotriol at least including: (a) reacting a C-22 phenylsulfonyl derivative of cholecalciferol of Formula 2, wherein R 1 and R 2 are the same or different and represent hydroxyl protecting groups, with a silyl derivative of alfa-hydroxy aldehyde of Formula 3, wherein R 3 represents silyl group of formula Si(R 4 )(R 5 )(R 6 ), where R 4 -R 6 are the same or different and represent C 1-6 alkyl or phenyl groups, in the presence of a strong organic base in an aprotic solvent, followed by reductive desulfonation of the obtained diastereomeric mixture of alfa-hydroxysulfones with sodium amalgam, removal of the hydroxyl protecting groups, and purification of the product. The process leads to the formation of calcipotriol containing less than 0.3% of the (22Z)-isomer. The obtained calcipotriol is free of mercury traces.

  一种制备骨化三醇的方法，至少包括以下步骤：（a）将式子2的C-22苯基磺酰基衍生物的R1和R2相同或不同，分别代表羟基保护基，与式子3的α-羟基醛的硅烷衍生物反应，其中R3代表公式Si（R4）（R5）（R6）的硅烷基，其中R4-R6相同或不同，代表C1-6烷基或苯基，在无水溶剂中存在强有机碱，随后还原得到的α-羟基磺酸盐的非对映异构体混合物与汞齐还原，去除羟基保护基，并纯化产物。该方法导致含有少于0.3％的（22Z）-异构体的骨化三醇的形成。所得到的骨化三醇不含有汞痕迹。
• [EN] PREPARATION METHOD OF STATIN COMPOUND AND BENZOTHIAZOLYL SULFONE COMPOUND USED THEREIN<br/>[FR] MÉTHODE DE SYNTHÈSE D'UNE STATINE ET BENZOTHIAZOLYLSULFONE Y ÉTANT EMPLOYÉE
  申请人：HANMI PHARM IND CO LTD

  公开号：WO2010077062A3

  公开（公告）日：2010-11-04