7-hydroxy-6-methoxyisochroman-3-one | 62726-52-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-hydroxy-6-methoxyisochroman-3-one
• 英文别名: 7-hydroxy-6-methoxy-isochroman-3-one；6-Methoxy-7-hydroxy-3-isochromanon；7-Hydroxy-6-methoxy-1,4-dihydroisochromen-3-one
• CAS: 62726-52-7
• 化学式: C₁₀H₁₀O₄
• 分子量: 194.187
• InChiKey: INYFFRWKQADFOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-hydroxy-6-methoxyisochroman-3-one 在 potassium permanganate 、 水 、 potassium carbonate 、 potassium hydroxide 作用下， 以 丙酮 为溶剂， 反应 28.0h， 生成 5-(benzyloxy)-2-(carboxymethyl)-4-methoxybenzoic acid
  参考文献：
  名称：

  Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons

  摘要：

  Hydroxylated analogues of the anticancer topoisomerase I (Top1) inhibitors indotecan (LMP400) and indimitecan (LMP776) have been prepared because (1) a variety of potent Top1 poisons are known that contain strategically placed hydroxyl groups, which provides a clear rationale for incorporating them in the present case, and (2) the hydroxylated compounds could conceivably serve as synthetic standards for the identification of metabolites. Indeed, incubating LMP400 and LMP776 with human liver microsomes resulted in two major metabolites of each drug, which had HPLC retention times and mass fragmentation patterns identical to those of the synthetic standards. The hydroxylated indotecan and indimitecan metabolites and analogues were tested as Top1 poisons and for antiproliferative activity in a variety of human cancer cell cultures and in general were found to be very potent. Differences in activity resulting from the placement of the hydroxyl group are explained by molecular modeling analyses.

  DOI：

  10.1021/jm300519w
• 作为产物：
  描述：

  7-(benzyloxy)-6-methoxyisochroman-3-one 以71%的产率得到
  参考文献：
  名称：

  SPANGLER R. J.; BECKMANN B. G.; KIM J. H., J. ORG. CHEM. , 1977, 42, NO 18, 2989-2996

  摘要：

  DOI：

文献信息

• A new synthesis of benzocyclobutenes. Thermal and electron impact induced decomposition of 3-isochromanones
  作者：Richard J. Spangler、Brian G. Beckmann、Jong Ho Kim

  DOI：10.1021/jo00438a009

  日期：1977.9
• Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons
  作者：Maris A. Cinelli、P. V. Narasimha Reddy、Peng-Cheng Lv、Jian-Hua Liang、Lian Chen、Keli Agama、Yves Pommier、Richard B. van Breemen、Mark Cushman

  DOI：10.1021/jm300519w

  日期：2012.12.27

  Hydroxylated analogues of the anticancer topoisomerase I (Top1) inhibitors indotecan (LMP400) and indimitecan (LMP776) have been prepared because (1) a variety of potent Top1 poisons are known that contain strategically placed hydroxyl groups, which provides a clear rationale for incorporating them in the present case, and (2) the hydroxylated compounds could conceivably serve as synthetic standards for the identification of metabolites. Indeed, incubating LMP400 and LMP776 with human liver microsomes resulted in two major metabolites of each drug, which had HPLC retention times and mass fragmentation patterns identical to those of the synthetic standards. The hydroxylated indotecan and indimitecan metabolites and analogues were tested as Top1 poisons and for antiproliferative activity in a variety of human cancer cell cultures and in general were found to be very potent. Differences in activity resulting from the placement of the hydroxyl group are explained by molecular modeling analyses.
• SPANGLER R. J.; BECKMANN B. G.; KIM J. H., J. ORG. CHEM. <JOCE-AH>, 1977, 42, NO 18, 2989-2996
  作者：SPANGLER R. J.、 BECKMANN B. G.、 KIM J. H.

  DOI：——

  日期：——