(E)-2-(2-(dimethylamino)ethyl)-6-(4-(3-(4-(dimethylamino)-phenyl)allyl)piperazin-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione | 1198398-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (E)-2-(2-(dimethylamino)ethyl)-6-(4-(3-(4-(dimethylamino)-phenyl)allyl)piperazin-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
• 英文别名: 2-[2-(dimethylamino)ethyl]-6-[4-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enyl]piperazin-1-yl]benzo[de]isoquinoline-1,3-dione
• CAS: 1198398-75-2
• 化学式: C₃₁H₃₇N₅O₂
• 分子量: 511.667
• InChiKey: OIKQBMFWYQNFRQ-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  50.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-(2-(dimethylamino)ethyl)-6-(piperazin-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione 、 3-(4-dimethylamino-phenyl)-propenal 在 三乙酰氧基硼氢化钠 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 3.0h， 以85%的产率得到(E)-2-(2-(dimethylamino)ethyl)-6-(4-(3-(4-(dimethylamino)-phenyl)allyl)piperazin-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
  参考文献：
  名称：

  Novel naphthalimide derivatives as potential apoptosis-inducing agents: Design, synthesis and biological evaluation

  摘要：

  A series of novel naphthalimide derivatives with flexible alkyl/aryl moieties were designed and synthesized. Their antitumor activities were evaluated against HeLa, A549, P388, HL-60, MCF-7, HCT-8 and A375 cancer cell lines in vitro. The preliminary results showed that most of the derivatives had comparable antitumor activities over Amonafide with the IC50 values of 10(-6) to 10(-5) M. More importantly, flow cytometric analysis indicated that the derivatives could effectively induce G(2)/M arrest and progress to apoptosis in HL-60 cell line after double staining with annexin V-FITC and propidium iodide. The present work provided a novel class of naphthalimide-based derivatives with potent apoptosis-inducing and antitumor activities for further optimization. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.07.011

文献信息

• Novel naphthalimide derivatives as potential apoptosis-inducing agents: Design, synthesis and biological evaluation
  作者：Aibin Wu、Yufang Xu、Xuhong Qian、Jin Wang、Jianwen Liu

  DOI：10.1016/j.ejmech.2009.07.011

  日期：2009.11

  A series of novel naphthalimide derivatives with flexible alkyl/aryl moieties were designed and synthesized. Their antitumor activities were evaluated against HeLa, A549, P388, HL-60, MCF-7, HCT-8 and A375 cancer cell lines in vitro. The preliminary results showed that most of the derivatives had comparable antitumor activities over Amonafide with the IC50 values of 10(-6) to 10(-5) M. More importantly, flow cytometric analysis indicated that the derivatives could effectively induce G(2)/M arrest and progress to apoptosis in HL-60 cell line after double staining with annexin V-FITC and propidium iodide. The present work provided a novel class of naphthalimide-based derivatives with potent apoptosis-inducing and antitumor activities for further optimization. (C) 2009 Elsevier Masson SAS. All rights reserved.