2-[(1-氨基-9,10-二氢-4-羟基-9,10-二羰基-2-蒽基)氧代]乙基苯基碳酸酯 | 28218-64-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 中文名称: 2-[(1-氨基-9,10-二氢-4-羟基-9,10-二羰基-2-蒽基)氧代]乙基苯基碳酸酯
• 英文名称: Adenosine 3',5'-bis(trihydrogen diphosphate)
• 英文别名: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy(phosphonooxy)phosphoryl]oxymethyl]oxolan-3-yl] phosphono hydrogen phosphate
• CAS: 28218-64-6
• 化学式: C₁₀H₁₇N₅O₁₆P₄
• 分子量: 587.16
• InChiKey: DWZMGWMGGHNJLF-KQYNXXCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.8
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  326
• 氢给体数：
  8
• 氢受体数：
  20

反应信息

• 作为产物：
  描述：

  腺嘌呤 生成 2-[(1-氨基-9,10-二氢-4-羟基-9,10-二羰基-2-蒽基)氧代]乙基苯基碳酸酯
  参考文献：
  名称：

  KOYA, AKIRA;SATO, AKIRA

  摘要：

  DOI：

文献信息

• Method for do novo biosynthesis of chondroitin sulfate
  申请人：Jiangnan University

  公开号：US10975405B2

  公开（公告）日：2021-04-13

  The present invention relates to a method for chondroitin sulfate biosynthesis, belongs to the field of pharmaceuticals. CS was biosynthesized by sulfating the chondroitin with C4ST or C6ST in Tris-HCl buffer assisted with 3′-phosphoadenosine 5′-phophosulfate (PAPS). C4ST and C46ST came from bioengineered Escherichia coli or Pichia pastoris. Chondroitin came from bioengineered Bacillus subtilis 168.

  本发明涉及一种硫酸软骨素的生物合成方法，属于制药领域。CS 的生物合成是在 3′-磷腺苷-5′-磷硫酸盐（PAPS）的辅助下，在 Tris-HCl 缓冲液中用 C4ST 或 C6ST 使软骨素硫酸化。C4ST 和 C46ST 来自生物工程大肠杆菌或 Pichia pastoris。软骨素来自生物工程枯草芽孢杆菌 168。
• Use of streptococcus pneumoniae acyl carrier protein synthase crystal structure in diagnostics, antimicrobial drug design, and biosensors
  申请人：——

  公开号：US20030068802A1

  公开（公告）日：2003-04-10

  Provided are methods of purifying and crystallizing Streptococcus pneumoniae acyl carrier protein synthase (AcpS) enzyme, crystals of AcpS, the use of such crystals to determine the three-dimensional structure of AcpS enzymes, and the three-dimensional structure of AcpS. The three-dimensional crystal structure of AcpS can be used in medical diagnostics to produce antibodies that permit detection of Streptococcus pneumoniae both in vitro and in vivo. The three-dimensional crystal structure of AcpS can also be used in pharmaceutical discovery and development to identify and design compounds that inhibit the biochemical activity of AcpS enzyme in bacteria. Inhibitory compounds identified in this way can be optimized by structure/activity studies to develop antibacterial pharmaceutical compounds useful for the prevention or treatment of bacterial infections.

  提供了纯化和结晶肺炎链球菌的方法 肺炎链球菌 提供了纯化和结晶肺炎链球菌酰基载体蛋白合成酶（AcpS）酶、AcpS 晶体、利用这些晶体确定 AcpS 酶的三维结构以及 AcpS 的三维结构的方法。AcpS 的三维晶体结构可用于医学诊断，产生的抗体可检测出 肺炎链球菌 的抗体。AcpS 的三维晶体结构还可用于药物发现和开发，以确定和设计能抑制细菌中 AcpS 酶生化活性的化合物。通过结构/活性研究，可以优化以这种方式确定的抑制性化合物，从而开发出有助于预防或治疗细菌感染的抗菌药物化合物。
• KOYA, AKIRA;SATO, AKIRA
  作者：KOYA, AKIRA、SATO, AKIRA

  DOI：——

  日期：——
• Method for Do Novo Biosynthesis of Chondroitin Sulfate
  申请人：Jiangnan University

  公开号：US20180135089A1

  公开（公告）日：2018-05-17

  The present invention relates to a method for chondroitin sulfate biosynthesis, belongs to the field of pharmaceuticals field. CS was biosynthesized by sulfating the chondroitin with C4ST or C6ST in Tris-HCI buffer assisted with 3′-phosphoadenosine 5′-phophosulfate (PAPS). C4ST and C46ST came from bioengineered Escherichia coli or Pichia pastoris . Chondroitin came from bioengineered Bacillus subtilis 168.
• US4230797A
  申请人：——

  公开号：US4230797A

  公开（公告）日：1980-10-28