1-[(2,4-dichlorophenoxy)acetyl]-2-[(3-methoxy-4-hydroxy)benzylidene]hydrazine | 54918-93-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-[(2,4-dichlorophenoxy)acetyl]-2-[(3-methoxy-4-hydroxy)benzylidene]hydrazine
• 英文别名: (2,4-dichloro-phenoxy)-acetic acid vanillylidenehydrazide；(2,4-Dichlor-phenoxy)-essigsaeure-vanillylidenhydrazid；2-(2,4-dichlorophenoxy)-N-[(4-hydroxy-3-methoxyphenyl)methylideneamino]acetamide
• CAS: 54918-93-3
• 化学式: C₁₆H₁₄Cl₂N₂O₄
• mdl: MFCD00390942
• 分子量: 369.204
• InChiKey: DOKAJUKKYYTNBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  80.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,4-二氯苯氧乙酸 在 一水合肼 作用下， 反应 4.05h， 生成 1-[(2,4-dichlorophenoxy)acetyl]-2-[(3-methoxy-4-hydroxy)benzylidene]hydrazine
  参考文献：
  名称：

  Li, Jian-Ping; Zheng, Peng-Zhi; Zhu, Jun-Ge, South African Journal of Chemistry, 2006, vol. 59, p. 90 - 92

  摘要：

  DOI：

文献信息

• Synthesis of 5-membered heterocycles and related compounds.
  作者：VISHNUJI RAM、HRIDVANAND PANDEY

  DOI：10.1248/cpb.22.2778

  日期：——

  Some 1-(2, 4-dichlorophenoxy and 2, 4, 5-trichlorophenoxy) acetyl-4-arylthiosemicarbazides were prepared from corresponding chlorophenoxyacetohydrazide. The resulting thiosemicarbazides were cyclised into 1, 3, 4-thiadiazoles and 5-mercapto-1, 2, 4-triazoles under different reaction conditions. The mercapto compounds were converted into sulphides and sulphones. N'-arylidene (2, 4-dichlorophenoxy) acetohydrazides and 5-substituted-1, 3, 4-oxadiazole-2-thiones were also prepared from (2, 4-dichlorophenoxy and 2, 4, 5-trichlorophenoxy) acetohydrazides separately and were subjected to Mannich reaction. Some of these compounds were evaluated as fungicides against Aspergillus niger.

  以相应的氯苯氧乙酰肼为原料，制备了一些 1-（2，4-二氯苯氧基和 2，4，5-三氯苯氧基）乙酰基-4-芳基硫代氨基甲酰肼。在不同的反应条件下，生成的硫代氨基甲酰肼被环化成 1，3，4-噻二唑和 5-巯基-1，2，4-三唑。巯基化合物被转化为硫化物和砜。此外，还分别从（2，4-二氯苯氧基和 2，4，5-三氯苯氧基）乙酰肼制备了 N'-芳基（2，4-二氯苯氧基）乙酰肼和 5-取代的-1，3，4-噁二唑-2-硫酮，并进行了曼尼希反应。其中一些化合物被评估为针对黑曲霉的杀真菌剂。
• Discovering phenoxy acetohydrazide derivatives as urease inhibitors and molecular docking studies
  作者：Muhammad Taha、Fazal Rahim、Imad Uddin、Mohd Amir、Naveed Iqbal、Abdul Wadood、Khalid Mohammed Khan、Nizam Uddin、Ashfaq Ur Rehman、Rai Khalid Farooq

  DOI：10.1080/07391102.2023.2212794

  日期：2024.4.12

  Helicobacter pylori causes severe stomach disorders and the use of enzyme inhibitors for treatment is one of the possible therapies. The great biological potential of imine analogs as urease inhibi...

  幽门螺杆菌会引起严重的胃部疾病，使用酶抑制剂进行治疗是可能的疗法之一。亚胺类似物作为脲酶抑制剂的巨大生物潜力...
• Chao; Sah; Oneto, Recueil des Travaux Chimiques des Pays-Bas
  作者：Chao、Sah、Oneto

  DOI：——

  日期：——
• Li, Jian-Ping; Zheng, Peng-Zhi; Zhu, Jun-Ge, South African Journal of Chemistry, 2006, vol. 59, p. 90 - 92
  作者：Li, Jian-Ping、Zheng, Peng-Zhi、Zhu, Jun-Ge、Liu, Rui-Jie、Qu, Gui-Rong

  DOI：——

  日期：——