2-Methoxy-10.11-dihydro-11-oxo-dibenz-1.4-thiazepin | 3158-77-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 2-Methoxy-10.11-dihydro-11-oxo-dibenz-1.4-thiazepin
• 英文别名: 2-methoxy-10H-dibenzo[b,f][1,4]thiazepin-11-one；2-methoxy-dibenzo [b, f] [1,4]-thiazepin-11-one；2-Methoxydibenzo[B,F][1,4]thiazepin-11(10H)-one；8-methoxy-5H-benzo[b][1,4]benzothiazepin-6-one
• CAS: 3158-77-8
• 化学式: C₁₄H₁₁NO₂S
• 分子量: 257.313
• InChiKey: WCFDCIHBQQEPFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2'-Amino-2-carboxy-4-methoxydiphenylsulfid 生成 2-Methoxy-10.11-dihydro-11-oxo-dibenz-1.4-thiazepin
  参考文献：
  名称：

  EP1201663

  摘要：

  公开号：

文献信息

• Process for preparing dibenzothiazepine compounds
  申请人：Murray Michael Paul

  公开号：US20070203336A1

  公开（公告）日：2007-08-30

  A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2′-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2′-carboxy-diphenylsulfide compound is suitably prepared by reducing a 2-nitro-2′-carboxy-diphenylsulfide compound in a lower aliphatic ester solvent; and the 2-nitro-2′-carboxy-diphenylsulfide compound is suitably prepared by reacting a nitrobenzene compound with a thiosalicylic acid compound in a mixture of a lower aliphatic alcohol and water.

  通过在酸性催化剂的存在下，将2-氨基-2'-羧基二苯硫醚化合物进行脱水缩合反应，可以适当地制备二苯并噻吩类化合物；2-氨基-2'-羧基二苯硫醚化合物可以通过在较低的脂肪酯溶剂中还原2-硝基-2'-羧基二苯硫醚化合物来适当地制备；而2-硝基-2'-羧基二苯硫醚化合物可以通过在较低脂肪醇和水的混合物中，将硝基苯化合物与硫代水杨酸类化合物反应来适当地制备。
• Process for preparing dibenzothiazepine derivatives
  申请人：Harada Katsumasa

  公开号：US20060173178A1

  公开（公告）日：2006-08-03

  A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f][1,4]thiazepin-11-one employable as a starting material for the preparation of 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperadinyldibenzothiazepine derivative which is known to be effective as an antipsychotic pharmaceutical, has the steps of reacting a nitrobenzene derivative with a thiosalicylic acid derivative, reducing the obtained 2-nitro-2′-carboxy-diphenylsulfide derivative, and subjecting the obtained 2-amino-2′-carboxy-diphenylsulfide derivative to dehydration-condensation reaction.

  一种制备二苯并噻吩衍生物的方法，例如二苯并[b，f][1,4]噻吩-11-酮，可用作制备11-[4-(2-(2-羟乙氧基)乙基)]-1-哌嗪基二苯并噻吩衍生物的起始物质，该衍生物已知对抗精神病药物有效，包括以下步骤：将硝基苯衍生物与硫氧化水杨酸衍生物反应，还原所得的2-硝基-2'-羧基二苯基硫醚衍生物，并将所得的2-氨基-2'-羧基二苯基硫醚衍生物进行脱水缩合反应。
• PROCESS FOR PRODUCING DIBENZOTHIAZEPINE DERIVATIVES
  申请人：Ube Industries, Ltd.

  公开号：EP1201663A1

  公开（公告）日：2002-05-02

  A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f] [1,4]thiazepin-11-one employable as a starting material for the preparation of 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperadinyldiberizothiazepine derivative which is known to be effective as an antipsychotic pharmaceutical, has the steps of reacting a nitrobenzene derivative with a thiosalicylic acid derivative, reducing the obtained 2-nitro-2'-carboxy-diphenylsulfide derivative, and subjecting the obtained 2-amino-2'-carboxy-diphenylsulfide derivative to dehydration-condensation reaction.

  一种制备二苯并硫氮杂卓衍生物如二苯并[b,f][1,4]硫氮杂卓-11-酮的工艺，可用作制备 11-[4-(2-(2-羟基乙氧基)乙基)]-1-哌啶基二苯并硫氮杂卓衍生物的起始原料，该衍生物已知可有效地用作抗精神病药物、其步骤包括使硝基苯衍生物与硫代水杨酸衍生物反应，还原得到的 2-硝基-2'-羧基-二苯硫醚衍生物，并使得到的 2-氨基-2'-羧基-二苯硫醚衍生物进行脱水缩合反应。
• PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS
  申请人：AstraZeneca UK Limited

  公开号：EP1996568A2

  公开（公告）日：2008-12-03
• US7045621B1
  申请人：——

  公开号：US7045621B1

  公开（公告）日：2006-05-16