2-[bis(2-methoxyethyl)phosphanyl]-N-[2-[bis(2-methoxyethyl)phosphanyl]ethyl]-N-(2-propylsulfanylethyl)ethanamine | 1375005-55-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[bis(2-methoxyethyl)phosphanyl]-N-[2-[bis(2-methoxyethyl)phosphanyl]ethyl]-N-(2-propylsulfanylethyl)ethanamine
• CAS: 1375005-55-2
• 化学式: C₂₁H₄₇NO₄P₂S
• 分子量: 471.622
• InChiKey: HWBCPMMHDVRNQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  29
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  65.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  氯化铜（64Cu） 、 2-[bis(2-methoxyethyl)phosphanyl]-N-[2-[bis(2-methoxyethyl)phosphanyl]ethyl]-N-(2-propylsulfanylethyl)ethanamine 在 ammonium acetate 作用下， 以 盐酸 、 水 、 乙腈 为溶剂， 以75%的产率得到
  参考文献：
  名称：

  Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X=O, S)

  摘要：

  Two series of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X) P-substituted aminodiphosphines (X = O, S) have been prepared and characterized by conventional physico-chemical techniques. The first series includes '3 + 1'-type complexes comprising an aromatic PNP-aminodiphosphine and acetonitrile or triphenylphosphine. In the second series, the central amine function of the PNP-ligand was substituted with functionalized pendant arms containing ether, hydroxyl or thioether groups to enhance the chelation ability of the ligand. Fully coordinated neutral and cationic complexes were isolated. A preliminary study investigating both the labeling of Cu-64 with the prototype PN(S)P ligand and the potential cytotoxic activity of the 'cold' [Cu(PN(S)P)][BF4] complex is reported. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.01.012
• 作为产物：
  描述：

  diethyl (2-((2-(propylthio)ethyl)amino)ethyl)phosphonate 在 lithium aluminium tetrahydride 、 正丁基锂 、 lithium perchlorate 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 为溶剂， 反应 10.0h， 生成 2-[bis(2-methoxyethyl)phosphanyl]-N-[2-[bis(2-methoxyethyl)phosphanyl]ethyl]-N-(2-propylsulfanylethyl)ethanamine
  参考文献：
  名称：

  Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X=O, S)

  摘要：

  Two series of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X) P-substituted aminodiphosphines (X = O, S) have been prepared and characterized by conventional physico-chemical techniques. The first series includes '3 + 1'-type complexes comprising an aromatic PNP-aminodiphosphine and acetonitrile or triphenylphosphine. In the second series, the central amine function of the PNP-ligand was substituted with functionalized pendant arms containing ether, hydroxyl or thioether groups to enhance the chelation ability of the ligand. Fully coordinated neutral and cationic complexes were isolated. A preliminary study investigating both the labeling of Cu-64 with the prototype PN(S)P ligand and the potential cytotoxic activity of the 'cold' [Cu(PN(S)P)][BF4] complex is reported. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.01.012

文献信息

• Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X=O, S)
  作者：Valentina Peruzzo、Cornelia Pretzsch、Francesco Tisato、Marina Porchia、Fiorenzo Refosco、Cristina Marzano、Valentina Gandin、Eik Schiller、Martin Walther、Hans-Jürgen Pietzsch

  DOI：10.1016/j.ica.2012.01.012

  日期：2012.5

  Two series of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X) P-substituted aminodiphosphines (X = O, S) have been prepared and characterized by conventional physico-chemical techniques. The first series includes '3 + 1'-type complexes comprising an aromatic PNP-aminodiphosphine and acetonitrile or triphenylphosphine. In the second series, the central amine function of the PNP-ligand was substituted with functionalized pendant arms containing ether, hydroxyl or thioether groups to enhance the chelation ability of the ligand. Fully coordinated neutral and cationic complexes were isolated. A preliminary study investigating both the labeling of Cu-64 with the prototype PN(S)P ligand and the potential cytotoxic activity of the 'cold' [Cu(PN(S)P)][BF4] complex is reported. (C) 2012 Elsevier B. V. All rights reserved.