6-bromo-2-propoxy-3-propylpyrido[2,3-d]pyrimidin-4(3H)-one | 187538-01-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 6-bromo-2-propoxy-3-propylpyrido[2,3-d]pyrimidin-4(3H)-one
• 英文别名: 6-bromo-2-propoxy-3-propylpyrido[2,3-d]pyrimidin-4-one
• CAS: 187538-01-8
• 化学式: C₁₃H₁₆BrN₃O₂
• 分子量: 326.19
• InChiKey: GFALABICUSQHNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  54.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-bromo-2-propoxy-3-propylpyrido[2,3-d]pyrimidin-4(3H)-one 、 6-bromo-3-propyl-2-(propylthio)pyrido[2,3-d]pyrimidin-4(3H)-one 、 6-iodo-2-propyloxy-3-[(tetrahydro-2-furanyl)methyl]-4(3H)-quinazolinone 、 6-bromo-2-propyloxy-3-[(tetrahydro-2-furanyl)methyl]-4(3H)-quinazolinone 、 6bromo-3-[(3-bromo-4,5-dihydro-5-isoxazolyl)methyl]-2-propoxy-4(3H)-quinazolinone 、 6,7-dibromo-2-propoxy-3-propylthieno[3,2-d]pyrimidin-4(3H)-one 、 6,8-diiodo-2-(propylthio)-3-[(tetrahydro-2-furanyl)methyl]-4(3H)-quinazolinone 、 3-(cyclopropylmethyl)-6-iodo-2-(propylthio)pyrido[2,3-d]pyrimidin-4(3H)-one 生成 7-bromo-2-propoxy-3-propylthieno[3,2-d]pyrimidin-4(3H)-one
  参考文献：
  名称：

  Fungicidal pyrimidinones

  摘要：

  本文披露了公式I化合物及其N-氧化物和农业适用盐，其可用作杀真菌剂，其中W为O，S（O）n或NR5; n为0，1或2; Q为O或S; G为融合的苯基，萘基，噻吩基，呋喃基，吡咯基，吡啶基，噻唑基，噁唑基，咪唑基，吡嗪基或嘧啶环; R1-R5如本文所定义。本文还披露了含有公式I化合物的组合物以及一种控制由真菌植物病原体引起的植物疾病的方法，该方法涉及施用有效量的公式I化合物。

  公开号：

  US06245770B1

文献信息

• [EN] FUNGICIDAL PYRIDAZINES<br/>[FR] PYRIDAZINES FONGICIDES
  申请人：DU PONT

  公开号：WO2010036553A1

  公开（公告）日：2010-04-01

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein R1, R2, R3, R4, X, Y and m are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  公开的是Formula 1的化合物，包括所有的几何和立体异构体、N-氧化物和盐，其中R1、R2、R3、R4、X、Y和m如披露中所定义。还公开了含有Formula 1化合物的组合物，以及用于控制由真菌病原体引起的植物疾病的方法，包括施用本发明的化合物或组合物的有效量。
• FUNGICIDAL MIXTURES
  申请人：Gregory Vann

  公开号：US20100240619A1

  公开（公告）日：2010-09-23

  Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1 N-oxides, and salts thereof, wherein R 1 , R 2 , A, G, W, Z 1 , X, J, and n are as defined in the disclosure, and (b) at least one additional fungicidal compound. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of the aforesaid composition. Also disclosed is a composition comprising component (a) of aforesaid composition and at least one insecticide. Also disclosed are compounds of Formula 1A, 1B and 1C, wherein R 1 , R 2 , A, G, W, Z 1 , X, J, n, Z 3 , M and J 1 are as defined in the disclosure.

  公开了一种含真菌化合物，包括：(a)至少一种选自公式1 N-氧化物的化合物，以及它们的盐类，其中R1，R2，A，G，W，Z1，X，J和n如公开所述定义，以及（b）至少一种额外的含真菌化合物。还公开了一种控制由真菌植物病原体引起的植物病害的方法，包括将有效量的前述组合物施用于植物或其部分，或施用于植物种子。还公开了一种组合物，包括前述组合物的组分(a)和至少一种杀虫剂。还公开了公式1A，1B和1C的化合物，其中R1，R2，A，G，W，Z1，X，J，n，Z3，M和J1如公开所述定义。
• FUNGICIDAL SUBSTITUTED AZOLES
  申请人：Selby Thomas Paul

  公开号：US20110045101A1

  公开（公告）日：2011-02-24

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein J is Q 2 or R 1 ; X is N, CR 2 or CQ 3 ; Y is N or CR 3 ; Z is N or CR 4 ; and Q 1 , Q 2 , Q 3 , R 1 R 2 and R 3 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  揭示了公式1的化合物，包括所有的几何和立体异构体，N-氧化物和盐，其中J是Q2或R1；X是N，CR2或CQ3；Y是N或CR3；Z是N或CR4；Q1，Q2，Q3，R1，R2和R3如披露中定义的。还披露了含有公式1化合物的组合物以及控制由真菌病原体引起的植物疾病的方法，包括施用本发明的化合物或组合物的有效量。
• [EN] FUNGICIDAL OXADIAZOLES<br/>[FR] OXADIAZOLES FONGICIDES
  申请人：DU PONT

  公开号：WO2018080859A1

  公开（公告）日：2018-05-03

  Disclosed are compounds of Formula I, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein R1, Z1, R2, Z2, J, s and f are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  揭示了公式I的化合物，包括所有几何和立体异构体、互变异构体、N-氧化物和盐，其中R1、Z1、R2、Z2、J、s和f的定义如披露所述。还揭示了含有公式I化合物的组合物，以及用于控制由真菌病原体引起的植物疾病的方法，包括施用本发明的化合物或组合物的有效量。
• [EN] FUNGICIDAL PYRAZOLES<br/>[FR] PYRAZOLES FONGICIDES
  申请人：DU PONT

  公开号：WO2010101973A1

  公开（公告）日：2010-09-10

  Disclosed are compounds of Formula (1), including all geometric and stereoisomers, JV-oxides, and salts thereof, wherein Q1 is a phenyl ring, naphthalenyl ring system, a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroaromatic bicyclic ring system, each as described with optional substituents as defined in the disclosure; Q2 is a phenyl ring, a naphthalenyl ring system, a 5- to 6-membered saturated, partially unsaturated or fully unsaturated heterocyclic ring, or an 8- to 10-membered heteroaromatic bicyclic ring system, each as described with optional substituents as defined in the disclosure; X is O, S(O)m, NR4, CR15R16, C(O) or C(=S); and R1, R1a, R2, R4, R15, R16 and m are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention. Also disclosed are compounds of Formula (2), including all geometric and stereoisomers, and salts thereof, wherein X is NH; and Q1, Q2 and R2 are as defined for Formula (1); which are useful as intermediates for preparing compounds of Formula (1).

  公开的是Formula (1)的化合物，包括所有的几何和立体异构体，JV-氧化物及其盐，其中Q1是苯环，萘环系统，5-至6-成员完全不饱和的杂环环或8-至10-成员的杂芳双环系统，每个如披露中定义的可选取代基；Q2是苯环，萘环系统，5-至6-成员饱和的、部分不饱和的或完全不饱和的杂环环，或8-至10-成员的杂芳双环系统，每个如披露中定义的可选取代基；X是O，S(O)m，NR4，CR15R16，C(O)或C(=S)；而R1、R1a、R2、R4、R15、R16和m如披露中定义。还公开了含有Formula (1)的化合物的组合物以及用于控制由真菌病原体引起的植物疾病的方法，包括施用本发明的化合物或组合物的有效量。还公开了Formula (2)的化合物，包括所有的几何和立体异构体，及其盐，其中X是NH；Q1、Q2和R2如Formula (1)中定义；它们可作为制备Formula (1)的化合物的中间体。