7-(methylamino)-3H-phenothiazine-3-one | 34185-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 7-(methylamino)-3H-phenothiazine-3-one
• 英文别名: MVB-CH3；7-methylamino-phenothiazin-3-one；7-Methylamino-phenothiazin-3-on；7-(Methylamino)phenothiazin-3-one
• CAS: 34185-23-4
• 化学式: C₁₃H₁₀N₂OS
• 分子量: 242.301
• InChiKey: NELLBAWPYRYUPL-UHFFFAOYSA-N

物化性质

• 沸点：
  422.0±45.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  硫酸 、 7-(methylamino)-3H-phenothiazine-3-one 生成 甲胺 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Bernthsen; Goske, Chemische Berichte, 1887, vol. 20, p. 933

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl-(7-methylamino-phenothiazin-3-yliden)-amine 在 水 作用下， 生成 7-(methylamino)-3H-phenothiazine-3-one
  参考文献：
  名称：

  Bernthsen; Goske, Chemische Berichte, 1887, vol. 20, p. 933

  摘要：

  DOI：

文献信息

• [EN] SYNTHESIS OF A THIOSULFONIC ACID BY A STEP OF PERIODATE MEDIATED OXIDATIVE COUPLING OF A THIOSULFONIC ACID WITH AN ANILINE<br/>[FR] SYNTHÈSE D'UN ACIDE THIOSULFONIQUE PAR UNE ÉTAPE DE COUPLAGE PAR OXYDATION MÉDIÉ PAR PERIODATE D'UN ACIDE THIOSULFONIQUE AVEC UNE ANILINE
  申请人：HARRINGTON CHARLES ROBERT

  公开号：WO2018115292A1

  公开（公告）日：2018-06-28

  The present invention pertains generally to the field of chemical synthesis, and more particularly to methods for the chemical synthesis of a thiosulfonic acid of Formula (1) by a step of periodate mediated oxidative coupling of a thiosulfonic acid of Formula (2) with an aniline of Formula (3), as described herein. The present invention also relates to such methods which incorporate one or more additional (subsequent and/or preceding) steps, for example, to prepare compounds of Formula (5) from compounds of Formula (1); to prepare compounds of Formula (6) from compounds of Formula (5); and to prepare compounds of Formula (2) from compounds of Formula (4), as described herein.

  本发明一般涉及化学合成领域，更具体地涉及一种通过亚硫酸酯类化合物（化学式（2））与苯胺（化学式（3））的间碘酸盐介导氧化偶联的步骤来化学合成一种亚硫酸硫酸的方法（化学式（1）），如本文所述。本发明还涉及这种方法中包括一个或多个额外的（随后和/或先行的）步骤，例如，从化合物（化学式（1））制备化合物（化学式（5））；从化合物（化学式（5））制备化合物（化学式（6））；从化合物（化学式（4））制备化合物（化学式（2）），如本文所述。
• Photobiological Properties of Positively Charged Methylene Violet Analogs
  作者：Melissa A. Houghtaling、Rushika Perera、Katherine E. Owen、Stephen Wagner、Richard J. Kuhn、Harry Morrison

  DOI：10.1562/0031-8655(2000)071<0020:ppopcm>2.0.co;2

  日期：——

  Abstract O-Methyl methylene violet (OMeMV), O-methyl bromomethylene violet (OMeBrMV) and O-methyl iodomethylene violet (OMeIMV) have been prepared in order to test their potential utility as anti-viral and anti-tumor phototoxic dyes. Rates of photosensitized toxicity of KB cells with 633 nm irradiation are (×10−19 photon−1): 2.4, 2.2, 1.9 and 0.17 for OMeIMV, OMeBrMV, methylene violet (MV) and OMeMV

  摘要 制备了 O-甲基亚甲基紫 (OMeMV)、O-甲基溴亚甲基紫 (OMeBrMV) 和 O-甲基碘亚甲基紫 (OMeIMV) 以测试它们作为抗病毒和抗肿瘤光毒性染料的潜在用途。KB 细胞在 633 nm 照射下的光敏毒性率为 (×10−19 光子−1)：OMeIMV、OMeBrMV、亚甲基紫 (MV) 和 OMeMV 分别为 2.4、2.2、1.9 和 0.17。633 nm 辐照磷酸盐缓冲盐水中辛德毕斯病毒的光敏灭活率为 (×10−18 光子−1)：MV、OMeIMV、OMeBrMV 和 OMeMV 分别为 3.3、1.8、0.99、0.15。单线态氧形成的量子效率确定为 OMeIMV，0.64；OMeBrMV，0.40；OMeMV，0.054。用双链 (ds) DNA 滴定染料导致可见吸收光谱中的红移和减色效应。通过平衡透析和紫外吸收滴定数据的 Scatchard 分析确定甲基化染料与
• Methods of chemical synthesis of substituted 10H-phenothiazine-3,7-diamine compounds
  申请人：WisTa Laboratories Ltd.

  公开号：US10323010B2

  公开（公告）日：2019-06-18

  The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.

  本发明一般涉及化学合成领域，更具体地说，涉及化学合成方法，其中包括通过还原胺化选择性烷基化步骤制备取代的式(1)10H-吩噻嗪-3,7-二胺化合物，在还原胺化条件下，相应的式(4)未取代二胺与醛/酮反应。本发明还涉及包含额外后续步骤和/或前述步骤的此类方法，例如，由式（1）化合物制备式（2）和（3）化合物，以及由式（5）、（6）、（7）、（8）和（9）化合物制备式（4）化合物。式（1）、式（2）和式（3）化合物可用于治疗蛋白质聚集性疾病，如阿尔茨海默病。
• Synthesis of a thiosulfonic acid by a step of periodate mediated oxidative coupling of a thiosulfonic acid with an aniline
  申请人：WisTa Laboratories Ltd.

  公开号：US10968174B2

  公开（公告）日：2021-04-06

  The present invention pertains generally to the field of chemical synthesis, and more particularly to methods for the chemical synthesis of a thiosulfonic acid of Formula (1) by a step of periodate mediated oxidative coupling of a thiosulfonic acid of Formula (2) with an aniline of Formula (3), as described herein. The present invention also relates to such methods which incorporate one or more additional (subsequent and/or preceding) steps, for example, to prepare compounds of Formula (5) from compounds of Formula (1); to prepare compounds of Formula (6) from compounds of Formula (5); and to prepare compounds of Formula (2) from compounds of Formula (4), as described herein.

  本发明一般涉及化学合成领域，更具体地说，涉及如本文所述，通过式（2）的硫代磺酸与式（3）的苯胺的过碘酸介导的氧化偶联步骤，化学合成式（1）的硫代磺酸的方法。本发明还涉及包含一个或多个附加（后续和/或前面）步骤的此类方法，例如，如本文所述，由式（1）化合物制备式（5）化合物；由式（5）化合物制备式（6）化合物；以及由式（4）化合物制备式（2）化合物。
• HANSER, CHRISTOF, JUNGE WISS., 3,(1989) N2, C. 32-39
  作者：HANSER, CHRISTOF

  DOI：——

  日期：——