4-(propylthio)naphthalen-1-ol | 19133-51-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(propylthio)naphthalen-1-ol
• 英文别名: 4-Propylthio-naphthol-(1)；4-Propylsulfanylnaphthalen-1-ol；4-propylsulfanylnaphthalen-1-ol
• CAS: 19133-51-8
• 化学式: C₁₃H₁₄OS
• 分子量: 218.32
• InChiKey: AXGAPGVEPBAUAE-UHFFFAOYSA-N

物化性质

• 熔点：
  83 °C(Solvent: Heptane)
• 沸点：
  393.8±25.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(propylthio)naphthalen-1-ol 在 氨 、 sodium 作用下， 以 乙醚 为溶剂， 反应 0.5h， 生成 4-Mercapto-[1]naphthol
  参考文献：
  名称：

  Effects of oxygen–sulfur substitution on glycosaminoglycan-priming naphthoxylosides

  摘要：

  Three series of sulfur-containing analogs to the selectively antiproliferative 2-(6-hydroxynaphthyl) beta-D-xylopyranoside were synthesized and their biological properties investigated. A short, general route to hydroxynaphthyl disulfides from dihydroxy-naphthalenes was developed to utilize the disulfide bond as a sulfur-selective protecting group to enable the orthogonal protection of hydroxyls and thiols. The results indicate that hydrophobic, uncharged oxygen-sulfur substituted naphthoxylosides are taken up by calls and initiate priming of GAG chains to a greater extent compared to the oxygen analogs. No correlation between priming ability and antiproliferative activity was observed. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.05.008
• 作为产物：
  描述：

  Dipropyl-4-hydroxy-naphthylsulfonium-perchlorat 以 吡啶 为溶剂， 生成 4-(propylthio)naphthalen-1-ol
  参考文献：
  名称：

  Ukai,S.; Hirose,K., Chemical and pharmaceutical bulletin, 1968, vol. 16, # 4, p. 606 - 612

  摘要：

  DOI：