CuCl₂[N,N,N′,N′,N″-pentamethyldiethylenetriamine] | 176590-39-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: CuCl₂[N,N,N′,N′,N″-pentamethyldiethylenetriamine]
• 英文别名: CuCl₂[PMDETA]；Cu(1,1,4,7,7-pentamethyldiethylenetriamine)Cl₂；Cu(PMDETA)Cl₂；[Cu(N,N,N',N'',N''-pentamethyldiethylenetriamine)Cl2]；dichlorocopper;N'-[2-(dimethylamino)ethyl]-N,N,N'-trimethylethane-1,2-diamine
• CAS: 176590-39-9
• 化学式: C₉H₂₃Cl₂CuN₃
• 分子量: 307.754
• InChiKey: BGBJJQRLGLAVGH-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.42
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  copper(l) chloride 、 CuCl₂[N,N,N′,N′,N″-pentamethyldiethylenetriamine] 以 not given 为溶剂， 生成 Cu(II)(N,N,N',N',N''-pentamethyldiethylenetriamine)Cl2(Cu(I)Cl)
  参考文献：
  名称：

  Breeze, Steven R.; Wang, Suning, Inorganic Chemistry, 1996, vol. 35, # 11, p. 3404 - 3408

  摘要：

  DOI：
• 作为产物：
  描述：

  copper dichloride 、 五甲基二乙烯三胺 以 二氯甲烷 为溶剂， 以96.1 %的产率得到CuCl₂[N,N,N′,N′,N″-pentamethyldiethylenetriamine]
  参考文献：
  名称：

  原子转移自由基聚合铜纳米药物

  摘要：

  采用几种具有抗癌活性的铜（Cu）配合物作为催化剂，在水介质中进行细乳液原子转移自由基聚合（ATRP），以简单的步骤和精确的理化性质制备负载Cu的纳米药物。该产品具有延长血液循环、改善肿瘤蓄积的作用，抗癌疗效优于顺铂，具有巨大的临床转化潜力。

  DOI：

  10.1002/anie.202402747

文献信息

• Thermomechanical Formation–Structure–Property Relationships in Photopolymerized Copper-Catalyzed Azide–Alkyne (CuAAC) Networks
  作者：Austin Baranek、Han Byul Song、Mathew McBride、Patricia Finnegan、Christopher N. Bowman

  DOI：10.1021/acs.macromol.6b00137

  日期：2016.2.23

  Bulk photopolymerization of a library of synthesized multifunctional azides and alkynes was carried out toward developing structure property relationships for CuAAC-based polymer networks. Multifunctional azides and alkynes were formulated with a copper catalyst and a photoinitiator, cured, and analyzed for their mechanical properties. Material properties such as the glass transition temperatures (T-g) show a strong dependence on monomer structure with T-g values ranging from 41 to 90 degrees C for the series of CuAAC monomers synthesized in this study. Compared to the triazoles, analogous thioether-based polymer networks exhibit a 45-49 degrees C lower T-g whereas analogous monomers composed of ethers in place of carbamates exhibit a 40 degrees C lower T-g. Here, the formation of the triazole moiety during the polymerization represents a critical component in dictating the material properties of the ultimate polymer network where material properties such as the rubbery modulus, cross-link density, and T-g all exhibit strong dependence on polymerization conversion, monomer composition, and structure postgelation.
• Breeze, Steven R.; Wang, Suning, Inorganic Chemistry, 1996, vol. 35, # 11, p. 3404 - 3408
  作者：Breeze, Steven R.、Wang, Suning

  DOI：——

  日期：——
• Breeze, Steven R.; Wang, Suning, Inorganic Chemistry, <hi>1996</hi>, vol. 35, # 11, p. 3404 - 3408
  作者：Breeze, Steven R.、Wang, Suning

  DOI：——

  日期：——
• Copper Nanodrugs by Atom Transfer Radical Polymerization
  作者：Peng Chen、Ziyan Song、Xuxia Yao、Weibin Wang、Lisong Teng、Krzysztof Matyjaszewski、Weipu Zhu

  DOI：10.1002/anie.202402747

  日期：——

  Several copper (Cu) complexes with anticancer activity were employed as catalysts for miniemulsion atom transfer radical polymerization (ATRP) in aqueous medium, producing Cu-loaded nanodrugs with simple steps and precise physiochemical property. The product showed prolonged blood circulation and improved tumor accumulation, with superior anticancer efficacy compared to cisplatin, showing great potential

  采用几种具有抗癌活性的铜（Cu）配合物作为催化剂，在水介质中进行细乳液原子转移自由基聚合（ATRP），以简单的步骤和精确的理化性质制备负载Cu的纳米药物。该产品具有延长血液循环、改善肿瘤蓄积的作用，抗癌疗效优于顺铂，具有巨大的临床转化潜力。