2-Iodo-5-methylsulfonylthiophene | 57800-97-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 2-Iodo-5-methylsulfonylthiophene
• 英文别名: 2-iodo-5-methanesulfonyl-thiophene；2-Jod-5-methansulfonyl-thiophen；2-iodo-5-methylsulfonyl-thiophene
• CAS: 57800-97-2
• 化学式: C₅H₅IO₂S₂
• 分子量: 288.13
• InChiKey: RDLMCNSUHXESFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  70.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Iodo-5-methylsulfonylthiophene 在 吡啶 、 sodium hydroxide 作用下， 生成 5-甲磺酰噻吩-2-羧酸
  参考文献：
  名称：

  潜在的噻吩化学疗法。第三部分 一些5-取代的2-噻吩基硫醚和砜

  摘要：

  DOI：

  10.1039/jr9540000237
• 作为产物：
  描述：

  2-(甲硫基)噻吩 在 双氧水 、 碘 、 溶剂黄146 、 mercury(II) oxide 、 苯 作用下， 生成 2-Iodo-5-methylsulfonylthiophene
  参考文献：
  名称：

  潜在的噻吩化学疗法。第三部分 一些5-取代的2-噻吩基硫醚和砜

  摘要：

  DOI：

  10.1039/jr9540000237

文献信息

• [EN] HETEROARYL COMPOUNDS<br/>[FR] COMPOSES HETEROARYLE
  申请人：LILLY CO ELI

  公开号：WO2004063194A1

  公开（公告）日：2004-07-29

  According to the present invention there is provided a compound of formula (I) wherein Z isR3 is lower alkyl or halo lower alkyl having from 2 to 6 carbon atoms or arylalkyl or -(CH2)s-V where V is a 3 to 8-membered ring which is cycloalkyl, cycloalkenyl, or heterocycloalkyl having one heteroatom selected from oxygen and sulfur ; s is independently 0, 1 or 2; M is hydrogen or halo or lower alkyl or perfluoro-lower alkyl;A is or where Y is oxygen or sulfur, and its pharmaceutically acceptable salts thereof. These compounds are considered to be useful for the treatment of type II Diabetes.

  根据本发明提供了一个化合物的公式(I)，其中Z是R3是具有2至6个碳原子的较低烷基或卤代较低烷基或芳基烷基或-(CH2)s-V，其中V是一个3至8元环，该环是环烷基、环烯基或含有氧和硫的杂环烷基中选择的一个杂原子；s独立地为0、1或2；M是氢或卤素或较低烷基或全氟较低烷基；A是或其中Y是氧或硫，并且其在药学上可接受的盐。这些化合物被认为对治疗II型糖尿病有用。
• Synthesis and Solvatochromic Properties of Donor-Acceptor-Substituted Oligothiophenes
  作者：Franz Effenberger、Frank Wuerthner、Felix Steybe

  DOI：10.1021/jo00112a032

  日期：1995.4

  The Pd-catalyzed cross coupling reaction of electron donor-substituted thiophenes 1 with electron acceptor-substituted halothiophenes 2,10 via organozinc intermediates or organotin compounds 5 to give bi-, ter-, and quaterthiophenes 3, 4, 6, 8, 12, 13, and 14 is described. (Dimethylamino)-bithiophenes 8 with acceptor groups of varying reactivity were prepared via 5d in 60-80% yield, whereas bithiophenes 6d,e were obtained as a mixture with phenylthiophenes 7d,e. Symmetrical substituted byproducts 11 were formed in the conversion of 1b with bromothiophenes 10 via organozinc compounds yielding oligothiophenes 6b and 12. The ter- and quaterthiophenes 13 and 14 were isolated in about 50-70% yield. The electronic interactions between donor and acceptor end groups in the conjugated bithiophenes 3, 4, and 8 are expressed in the intensive and markedly solvatochromic CT transitions. The solvatochromic behavior of 3, 4, and 8 was determined by linear regression analyses of absorption maxima in 11 solvents, whereby bithiophene 3d was found to be a very appropriate indicator dye whose absorption wavenumbers ($) over bar nu(max)(3d) in aliphatic and dipolar aprotic and-on consideration of the polarizability correction term d delta-in aromatic and chlorinated solvents excellently correlate with the pi* values defined by Kamlet and Taft.
• Hurtel, Patrice; Decroix, Bernard; Morel, Jean, Journal of Chemical Research, Miniprint, 1983, # 3, p. 725 - 754
  作者：Hurtel, Patrice、Decroix, Bernard、Morel, Jean、Terrier, Francois

  DOI：——

  日期：——