3-(2-Benzooxazolylthio)propylamine | 1019129-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 3-(2-Benzooxazolylthio)propylamine
• 英文别名: 3-(1,3-benzoxazol-2-ylsulfanyl)propan-1-amine
• CAS: 1019129-68-0
• 化学式: C₁₀H₁₂N₂OS
• 分子量: 208.284
• InChiKey: UBPYEPPDFVRDRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  77.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(2-Benzooxazolylthio)propylamine 、 2'-O-acetate-3-O-descladinosyl-3-keto-10,11-anhydro-12-O-imidazolylcarbonyl-6-O-methylerythromycin 以 水 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains

  摘要：

  A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive and resistant respiratory pathogens. The newly synthesized 9a, 9e, 9k and 9n showed a similar antimicrobial spectrum and comparable activity to telithromycin, the commercial ketolide antibacterial. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.11.004
• 作为产物：
  描述：

  2-(3-(benzoxazol-2-ylthio)propyl)-1H-isoindole-1,3(2H)-dione 在 肼 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 生成 3-(2-Benzooxazolylthio)propylamine
  参考文献：
  名称：

  Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains

  摘要：

  A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive and resistant respiratory pathogens. The newly synthesized 9a, 9e, 9k and 9n showed a similar antimicrobial spectrum and comparable activity to telithromycin, the commercial ketolide antibacterial. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.11.004

文献信息

• Furan derivatives having anti-ulcer activity
  申请人：Ausonia Farmaceutici s.r.l.

  公开号：US04634701A1

  公开（公告）日：1987-01-06

  Compounds of formula (I): ##STR1## wherein: A represents a CH-NO.sub.2 group or a N-CN group; B represents CH.sub.2, O, S or a direct bond; R represents a bicyclic or polycyclic residue, variously substituted and functionalized; R.sup.1 and R.sup.2, which may be the same or different, are hydrogen or C.sub.1 -C.sub.4 alkyl groups; and n and m, which may be the same or different, are 0, 1, 2, 3 or 4; are valuable pharmacological agents.

  式(I)的化合物：##STR1## 其中：A代表一个CH-NO.sub.2基团或一个N-CN基团；B代表CH.sub.2、O、S或直接键；R代表一个不同取代和官能化的双环或多环残基；R.sup.1和R.sup.2，可能相同或不同，是氢或C.sub.1-C.sub.4烷基基团；n和m，可能相同或不同，是0、1、2、3或4；这些均是有价值的药理学制剂。
• US4634701A
  申请人：——

  公开号：US4634701A

  公开（公告）日：1987-01-06
• Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains
  作者：Xiao-zhuo Chen、Peng Xu、Lu Liu、Dan Zheng、Ping-sheng Lei

  DOI：10.1016/j.ejmech.2010.11.004

  日期：2011.1

  A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive and resistant respiratory pathogens. The newly synthesized 9a, 9e, 9k and 9n showed a similar antimicrobial spectrum and comparable activity to telithromycin, the commercial ketolide antibacterial. (C) 2010 Elsevier Masson SAS. All rights reserved.