10-(acridin-9-yl)isoalloxazine | 1610850-07-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 10-(acridin-9-yl)isoalloxazine
• 英文别名: 10-Acridin-9-ylbenzo[g]pteridine-2,4-dione；10-acridin-9-ylbenzo[g]pteridine-2,4-dione
• CAS: 1610850-07-1
• 化学式: C₂₃H₁₃N₅O₂
• 分子量: 391.389
• InChiKey: FTYAXEDFTXEUDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四氧嘧啶 、 9-(2-aminoanilino)acridine hydrochloride 在 硼酸 、 溶剂黄146 作用下， 反应 0.17h， 以88%的产率得到10-(acridin-9-yl)isoalloxazine
  参考文献：
  名称：

  A rapid, chromatography-free route to substituted acridine–isoalloxazine conjugates under microwave irradiation

  摘要：

  Microwave irradiation was applied to a sequence of condensation reactions from readily available 9-chloroacridines to provide a range of novel acridine-isoalloxazine conjugates. The combination of these two moieties, both of biological interest, was achieved by a chromatography-free route. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.04.035

文献信息

• A rapid, chromatography-free route to substituted acridine–isoalloxazine conjugates under microwave irradiation
  作者：Stephen C. Johns、Laurie L.E. Crouch、Stephen Grieve、Holly L. Maloney、Gary R. Peczkowski、Allison E. Jones、Duncan Sharp、Robert B. Smith

  DOI：10.1016/j.tetlet.2014.04.035

  日期：2014.5

  Microwave irradiation was applied to a sequence of condensation reactions from readily available 9-chloroacridines to provide a range of novel acridine-isoalloxazine conjugates. The combination of these two moieties, both of biological interest, was achieved by a chromatography-free route. (C) 2014 Elsevier Ltd. All rights reserved.