2-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophene | 109213-01-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophene
• 英文别名: 2-(2-Thiophen-2-ylethoxy)oxane
• CAS: 109213-01-6
• 化学式: C₁₁H₁₆O₂S
• 分子量: 212.313
• InChiKey: BIGICSNJGFWFNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophene 生成 5-[2-(oxan-2-yloxy)ethyl]thiophene-2-sulfonamide
  参考文献：
  名称：

  GRAHAM, SAMUEL L.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-噻吩乙醇 生成 2-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophene
  参考文献：
  名称：

  GRAHAM, SAMUEL L.

  摘要：

  DOI：

文献信息

• Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols
  作者：Masatoshi Kiuchi、Kunitomo Adachi、Toshiyuki Kohara、Masanori Minoguchi、Tokushi Hanano、Yoshiyuki Aoki、Tadashi Mishina、Masafumi Arita、Noriyoshi Nakao、Makio Ohtsuki、Yukio Hoshino、Koji Teshima、Kenji Chiba、Shigeo Sasaki、Tetsuro Fujita

  DOI：10.1021/jm000173z

  日期：2000.7.1

  allograft. A phenyl ring was introduced into the alkyl chain of the lead compound 3, which is an immunosuppressive agent structurally simplified from myriocin (1, ISP-I) via compound 2. The potency of the various compounds was dependent upon the position of the phenyl ring within the alkyl side chain. The most suitable length between the quaternary carbon atom and the phenyl ring was two carbon atoms

  合成了一系列2-取代的2-氨基丙烷-1,3-二醇，并评估了它们对大鼠皮肤同种异体移植细胞的淋巴细胞减少作用和免疫抑制作用。通过化合物2，苯环被引入到先导化合物3的烷基链中，该化合物是一种从十四烷（1，ISP-1）结构上简化的免疫抑制剂。各种化合物的效价取决于苯环的位置在烷基侧链内。季碳原子和苯环之间的最合适的长度是两个碳原子。连续合成2-取代的2-氨基乙醇，并用a淋巴结增加试验评估大鼠的T细胞减少作用和免疫抑制作用。季碳的绝对构型影响活性，化合物6的（pro-S）-羟甲基对于有效的免疫抑制活性至关重要。6的（原-R）-羟甲基的有利取代基是羟烷基（羟乙基和羟丙基）或低级烷基（甲基和乙基）。发现2-氨基-2- [2-（2-（4-辛基苯基）乙基]丙烷-1,3-二醇盐酸盐（6，FTY720）具有相当大的活​​性，并有望用作器官移植的免疫抑制药物。
• Substituted thiophene-2-sulfanomide and antiglaucoma compositions containing them
  申请人：Merck & Co., Inc.

  公开号：EP0221806A1

  公开（公告）日：1987-05-13

  Thiophene-2-sulfonamides with a 5-alkyl-substituent are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.

  具有 5-烷基取代基的噻吩-2-磺酰胺类化合物是一种碳酸酐酶抑制剂，可用于治疗眼压升高。
• Synthesis and evaluation of new 18F-labelled thienylcyclohexylpiperidine (TCP) analogues as radioligands for the NMDA receptor-channel complex
  作者：Yoshihiko Shibayama、Shigeki Sasaki、Urara Tomita、Toru Nishikawa、Minoru Maeda

  DOI：10.1002/(sici)1099-1344(199601)38:1<77::aid-jlcr815>3.0.co;2-x

  日期：1996.1
• Excellent acceleration of the Diels-Alder reaction by microwave irradiation for the synthesis of new fluorine-substituted ligands of NMDA receptor
  作者：Shigeki Sasaki、Nobuyasu Ishibashi、Tshuneo Kuwamura、Hiromi Sano、Masaki Matoba、Tohru Nisikawa、Minoru Maeda

  DOI：10.1016/s0960-894x(98)00541-1

  日期：1998.11

  A series of 6,11-ethanobenzo[b]quinolizinium derivatives was synthesized through the Diels-Alder reaction between azoniaanthracne and the corresponding 1,1-disubstituted olefin. After a systematic investigation for achieving rapid synthesis, it was found that the reaction is accelerated in polar media such as H2O and trifluoroethanol. In particular, excellent acceleration was effected by microwave irradiation. The new fluorine-substituted ligands thus obtained exhibited potential affinity toward NMDA receptors. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Tuning the Electrical Conductivity and Self-Assembly of Regioregular Polythiophene by Block Copolymerization: Nanowire Morphologies in New Di- and Triblock Copolymers We gratefully acknowledge support from the NSF (CHE-9807707).
  作者：Jinsong Liu、Elena Sheina、Tomasz Kowalewski、Richard D. McCullough

  DOI：10.1002/1521-3773(20020118)41:2<329::aid-anie329>3.0.co;2-m

  日期：2002.1.18