Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same
申请人:Duquesne University of the Holy Spirit
公开号:US20170050978A1
公开(公告)日:2017-02-23
The present invention provides a compound of Formula I:
wherein R is H, a methyl group, an ethyl group, a n-propyl group, an iso-propyl group, or a n-butyl group; and R
1
is H, a 4′-methyl group, a 4′-OH, a 4′-OMe group, a 2′,3′-C
2
H
4
group, a; 3′,4′-C
2
H
4
group, a 3′,4′-diF, a 3′,4′,5′-triF, or a 4′-OCF
3
; and optionally including a salt or a hydrate of said compound, and further provides a pharmaceutical composition comprising the compound of Formula I and one or more acceptable pharmaceutical carriers. A method of treating a patient having cancer comprising administering a therapeutically effective amount of a compound of Formula I, or a pharmaceutical composition comprising a compound of Formula I and one or more acceptable pharmaceutical carriers to the patient is disclosed.