2-[1-[2-[5-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]pentyl-methylamino]-2-oxoethyl]cyclopentyl]acetic acid | 1449213-70-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-[1-[2-[5-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]pentyl-methylamino]-2-oxoethyl]cyclopentyl]acetic acid
• CAS: 1449213-70-0
• 化学式: C₃₁H₄₀N₂O₅
• 分子量: 520.669
• InChiKey: CUVGANORGNMDSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  38
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  87.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N,N'-dimethylpentane-1,5-diamine 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 2-[1-[2-[5-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]pentyl-methylamino]-2-oxoethyl]cyclopentyl]acetic acid
  参考文献：
  名称：

  [EN] MACROCYCLIC COMPOUNDS FOR MODULATING IL-17
  [FR] COMPOSÉS MACROCYCLIQUES POUR UNE MODULATION D'IL-17

  摘要：

  这项发明通常涉及公式I的大环化合物及其治疗用途。更具体地，该发明涉及调节IL-17活性的大环化合物，或者用于治疗炎症性疾病和其他与IL-17相关的疾病的大环化合物。

  公开号：

  WO2013116682A1

文献信息

• MACROCYCLIC COMPOUNDS FOR MODULATING IL-17
  申请人：ENSEMBLE THERAPEUTICS CORPORATION

  公开号：US20150005319A1

  公开（公告）日：2015-01-01

  The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders.

  本发明涉及公式I的大环化合物及其治疗用途。更具体地，本发明涉及调节IL-17活性或用于治疗医疗情况（例如炎症性疾病和其他IL-17相关疾病）的大环化合物。
• Metalloporphyrin Polymer Functionalized Substrate
  申请人：Sharp Laboratories of America, Inc.

  公开号：US20150005464A1

  公开（公告）日：2015-01-01

  A method is provided for fabricating a metalloporphyrin polymer on a substrate. The method creates a functionalized substrate by attaching an anchor group of a linker, including a terminal alkyne group, to a substrate surface. The functionalized substrate is then exposed to metalloporphyrin monomers, where each metalloporphyrin monomer includes at least two terminal alkyne groups. A plurality of metalloporphyrin monomers (e.g., zinc porphyrin monomers) are thus linked via the metalloporphyrin monomer terminal alkyne groups, forming a metalloporphyrin polymer attached to the substrate. In one aspect, linking the plurality of metalloporphyrin monomers via the metalloporphyrin monomer terminal alkyne groups includes forming butadiyne groups between adjacent metalloporphyrins. Then, forming the metalloporphyrin polymer attached to the substrate includes attaching the metalloporphyrin polymer, via a metalloporphyrin monomer terminal alkyne group, to the terminal alkyne group of an associated linker. Alternatively stated, the metalloporphyrin polymer is attached to the substrate via a polyalkyne group.
• US9090743B2
  申请人：——

  公开号：US9090743B2

  公开（公告）日：2015-07-28
• US9284283B2
  申请人：——

  公开号：US9284283B2

  公开（公告）日：2016-03-15
• [EN] A METALLOPORPHYRIN POLYMER FUNCTIONALIZED SUBSTRATE AND METHOD FOR FABRICATING A METALLOPORPHYRIN POLYMER ON A SUBSTRATE<br/>[FR] SUBSTRAT FONCTIONNALISÉ PAR UN POLYMÈRE DE METALLOPORPHYRINE ET PROCÉDÉ DE FABRICATION D'UN POLYMÈRE DE METALLOPORPHYRINE SUR UN SUBSTRAT
  申请人：SHARP KK

  公开号：WO2015011885A1

  公开（公告）日：2015-01-29

  A method is provided for fabricating a metalloporphyrin polymer on a substrate. The method creates a functionalized substrate by attaching an anchor group of a linker, including a terminal alkyne group, to a substrate surface. The functionalized substrate is then exposed to metalloporphyrin monomers, where each metalloporphyrin monomer includes at least two terminal alkyne groups. A plurality of metalloporphyrin monomers (e.g., zinc porphyrin monomers) are thus linked via the metalloporphyrin monomer terminal alkyne groups, forming a metalloporphyrin polymer attached to the substrate. In one aspect, linking the plurality of metalloporphyrin monomers via the metalloporphyrin monomer terminal alkyne groups includes forming butadiyne groups between adjacent metalloporphyrins. Then, forming the metalloporphyrin polymer attached to the substrate includes attaching the metalloporphyrin polymer, via a metalloporphyrin monomer terminal alkyne group, to the terminal alkyne group of an associated linker. Alternatively stated, the metalloporphyrin polymer is attached to the substrate via a polyalkyne group.