(E,5S)-5-(4-fluorophenyl)-5-[[(4S,5S)-2-oxido-4,5-diphenyl-1,3-di(propan-2-yl)-1,3,2-diazaphospholidin-2-ium-2-yl]amino]-1-phenylpent-1-en-3-one | 1601490-92-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E,5S)-5-(4-fluorophenyl)-5-[[(4S,5S)-2-oxido-4,5-diphenyl-1,3-di(propan-2-yl)-1,3,2-diazaphospholidin-2-ium-2-yl]amino]-1-phenylpent-1-en-3-one
• CAS: 1601490-92-9
• 化学式: C₃₇H₄₁FN₃O₂P
• 分子量: 609.724
• InChiKey: APDPVLUNWKHFBL-MIABEVHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  、 苄叉丙酮 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 30.75h， 以90%的产率得到(E,5S)-5-(4-fluorophenyl)-5-[[(4S,5S)-2-oxido-4,5-diphenyl-1,3-di(propan-2-yl)-1,3,2-diazaphospholidin-2-ium-2-yl]amino]-1-phenylpent-1-en-3-one
  参考文献：
  名称：

  Asymmetric synthesis of β′-amino-α,β-enones via addition of α,β-unsaturated ketone-derived enolates to chiral N-phosphonyl imines

  摘要：

  Efficient asymmetric Mannich addition reactions between alpha,beta-unsaturated ketone derived enolates and N-phosphonyl imines were reported. These reactions could proceed smoothly for a variety of imine substrates with good (up to 96%) chemical yields and excellent diastereoselectivities (up to 98:2 dr). The method reported in this work provides an easy access to chiral beta'-amino-alpha,beta-enones. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.03.005

文献信息

• Asymmetric synthesis of β′-amino-α,β-enones via addition of α,β-unsaturated ketone-derived enolates to chiral N-phosphonyl imines
  作者：Yiwen Xiong、Haibo Mei、Jianlin Han、Guigen Li、Yi Pan

  DOI：10.1016/j.tetlet.2014.03.005

  日期：2014.4

  Efficient asymmetric Mannich addition reactions between alpha,beta-unsaturated ketone derived enolates and N-phosphonyl imines were reported. These reactions could proceed smoothly for a variety of imine substrates with good (up to 96%) chemical yields and excellent diastereoselectivities (up to 98:2 dr). The method reported in this work provides an easy access to chiral beta'-amino-alpha,beta-enones. (C) 2014 Elsevier Ltd. All rights reserved.