Hydrazinecarbodithioic acid pentyl ester | 66528-18-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫基化合物
• 英文名称: Hydrazinecarbodithioic acid pentyl ester
• 英文别名: pentyl N-aminocarbamodithioate
• CAS: 66528-18-5
• 化学式: C₆H₁₄N₂S₂
• mdl: MFCD19202334
• 分子量: 178.323
• InChiKey: GSNOFELWCRUDEC-UHFFFAOYSA-N

物化性质

• 沸点：
  273.0±23.0 °C(Predicted)
• 密度：
  1.121±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  95.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-碘戊烷 、 二硫代碳酸单酰肼肼盐 以 乙醇 为溶剂， 生成 Hydrazinecarbodithioic acid pentyl ester
  参考文献：
  名称：

  Syntheses and uncoupling activities of alkyl dithiocarbazates and alkyl pyridinecarbonyldithiocarbazates

  摘要：

  A series of alkyl dithiocarbazates, alkyl 3-picolinoyldithiocarbazates, alkyl 3-nicotinoyldithiocarbazates, alkyl 3-isonicotinoyldithiocarbazates, and alkyl 3-picolinoyl-2-methyldithiocarbazates was prepared. These alkyl pyridinecarbonyldithiocarbazates were shown to be uncouplers of oxidative phosphorylation in mitochondria. The finding that uncoupling activity increased with increase in the length of the alkyl chains of the compounds indicates that hydrophobicity influences the activity. The nonyl derivatives had the highest activity. The results also suggested that a dissociable acidic proton is necessary for the uncoupling activity.

  DOI：

  10.1021/jm00204a018

文献信息

• Inhibitors of Human Cathepsin L, Cathepsin B, and Cathepsin S
  申请人：Diamond Scott L.

  公开号：US20110207726A1

  公开（公告）日：2011-08-25

  The present invention is directed to novel protease inhibitors that are specific for cathepsin L, cathepsin B, and cathepsin S. Accordingly, the present invention encompasses compositions and methods for treating and preventing diseases and disorders associated with cathepsin L, cathepsin B, or cathepsin S function or activity.
• [EN] INHIBITORS OF HUMAN CATHEPSIN L, CATHEPSIN B, AND CATHEPSIN S<br/>[FR] INHIBITEURS DES CATHEPSINES L, B ET S HUMAINES
  申请人：UNIV PENNSYLVANIA

  公开号：WO2009136997A2

  公开（公告）日：2009-11-12

  The present invention is directed to novel protease inhibitors that are specific for cathepsin L, cathepsin B, and cathepsin S. Accordingly, the present invention encompasses compositions and methods for treating and preventing diseases and disorders associated with cathepsin L, cathepsin B, or cathepsin S function or activity.
• Syntheses and uncoupling activities of alkyl dithiocarbazates and alkyl pyridinecarbonyldithiocarbazates
  作者：Seiju Kubota、Masayuki Uda、Yasuyuki Mori、Fujio Kametani、Hiroshi Terada

  DOI：10.1021/jm00204a018

  日期：1978.6

  A series of alkyl dithiocarbazates, alkyl 3-picolinoyldithiocarbazates, alkyl 3-nicotinoyldithiocarbazates, alkyl 3-isonicotinoyldithiocarbazates, and alkyl 3-picolinoyl-2-methyldithiocarbazates was prepared. These alkyl pyridinecarbonyldithiocarbazates were shown to be uncouplers of oxidative phosphorylation in mitochondria. The finding that uncoupling activity increased with increase in the length of the alkyl chains of the compounds indicates that hydrophobicity influences the activity. The nonyl derivatives had the highest activity. The results also suggested that a dissociable acidic proton is necessary for the uncoupling activity.