N-tritylaziridine | 26643-30-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-tritylaziridine
• 英文别名: 1-(Triphenylmethyl)aziridine；1-tritylaziridine
• CAS: 26643-30-1
• 化学式: C₂₁H₁₉N
• 分子量: 285.389
• InChiKey: VGVSQCOSLXVVHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-tritylaziridine 以 四氢呋喃 、 水 、 乙腈 为溶剂， 生成 (2S-trans)-[1-[Hydroxy[2-[(triphenylmethyl)amino]ethoxy]phosphinyl]-2-methyl-4-oxo-3-azetidinyl]carbamic acid, phenylmethyl ester, monosodium salt
  参考文献：
  名称：

  1-(substituted phosphorous)-azetidinone antibacterials

  摘要：

  2-氮杂环丙酮在其结构式中3-位带有酰氨基取代基并在1-位带有活化基团时表现出抗菌活性。

  公开号：

  US04723002A1
• 作为产物：
  描述：

  methane sulfonyl chloride 、 三苯基氯甲烷 在 三乙胺 作用下， 以 盐酸 、 甲醇 、 二氯甲烷 为溶剂， 生成 N-tritylaziridine
  参考文献：
  名称：

  Novel compounds and methods for synthesis and therapy

  摘要：

  描述了新化合物。这些化合物通常包括一个酸性基团，一个碱性基团，一个取代氨基或N-酰基和一个具有可选择羟基化的烷基部分的基团。还描述了包括本发明的抑制剂的药物组合物。还描述了在疑似含有神经氨酸酶的样品中抑制神经氨酸酶的方法。还描述了抗原材料、聚合物、抗体、本发明化合物与标记物的结合物以及用于检测神经氨酸酶活性的测定方法。

  公开号：

  US20040053999A1

文献信息

• Compounds and methods for synthesis and therapy
  申请人：Gilead Sciences, Inc.

  公开号：US05952375A1

  公开（公告）日：1999-09-14

  Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

  描述了新化合物。这些化合物通常包括一个酸性基团，一个碱性基团，一个取代氨基或N-酰基和一个具有可选择羟基化的烷基部分的基团。还描述了包括本发明的抑制剂的药物组合物。还描述了在疑似含有神经氨酸酶的样品中抑制神经氨酸酶的方法。还描述了抗原材料、聚合物、抗体、本发明化合物与标记物的结合物以及检测神经氨酸酶活性的测定方法。
• Carbocyclic compounds
  申请人：Gilead Sciences, Inc.

  公开号：US05763483A1

  公开（公告）日：1998-06-09

  Novel carbocyclic compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

  描述了新颖的环烷化合物。这些化合物通常包括一个酸性基团，一个碱性基团，一个取代氨基或N-酰基的基团，以及一个具有可选择羟基化的烷烃基团。还描述了包括本发明的抑制剂的药物组合物。还描述了在疑似含有神经氨酸酶的样品中抑制神经氨酸酶的方法。还描述了抗原材料、聚合物、抗体、与标记物结合的本发明化合物的共轭物，以及用于检测神经氨酸酶活性的测定方法。
• NOVEL COMPOUNDS AND METHODS FOR SYNTHESIS AND THERAPY
  申请人：BISCHOFBERGER NORBERT W.

  公开号：US20050176758A1

  公开（公告）日：2005-08-11

  Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

  本发明涉及新型化合物。该化合物通常包含一个酸性基团、一个碱性基团、一个取代的氨基或N-酰基和一个具有可选羟基化的烷基部分。本发明还涉及包含所述抑制剂的制药组合物。还描述了用于抑制怀疑含有神经氨酸酶的样品中神经氨酸酶的方法。还描述了抗原材料、聚合物、抗体、标记化合物的结合物以及用于检测神经氨酸酶活性的测定方法。
• VERSATILE NATIVE CHEMICAL LIGATION TECHNOLOGIES
  申请人：Washington State University

  公开号：US20140213758A1

  公开（公告）日：2014-07-31

  Novel methods of native chemical ligation are provided. The methods involve reacting a thioacid (e.g. a peptide thioacid) with an aziridinyl compound (e.g. an aziridinyl peptide) or glycosylamine under mild conditions without the use of protecting groups, and without requiring that a cysteine residue be present in the ligation product. Initial coupling of the thioacid and the aziridinyl compound yields a ligation product containing an aziridinyl ring. Optional subsequent opening of the aziridinyl ring (e.g. via a nucleophilic attack) produces a linearized and modified ligation product. Coupling of a peptide thioacid and glycosylamine yields a glycosylated peptide.

  提供一种原生化学连接的新方法。该方法涉及在温和条件下反应硫代酸（例如肽硫代酸）与环氧丙烷化合物（例如环氧丙烷肽）或者葡萄糖氨基化合物，无需使用保护基，并且不需要在连接产物中存在半胱氨酸残基。硫代酸和环氧丙烷化合物的初始偶联产生含有环氧丙烷环的连接产物。选择性地通过环氧丙烷环的后续开放（例如通过亲核攻击）可产生线性化和改性的连接产物。肽硫代酸和葡萄糖氨基化合物的偶联产生糖基化肽。
• AZIRIDINE MEDIATED NATIVE CHEMICAL LIGATION
  申请人：Washington State University

  公开号：US20130131311A1

  公开（公告）日：2013-05-23

  Improved methods of native chemical ligation are provided. The methods involve reacting a thioacid (e.g. a peptide thioacid) with an aziridinyl compound (e.g. an aziridinyl peptide) under mild conditions without the use of protecting groups, and without requiring that a cysteine residue be present in the ligation product. Initial coupling of the thioacid and the aziridinyl compound yields a ligation product which contains an aziridinyl ring. Subsequent opening of the aziridinyl ring (e.g. via a nucleophilic attack) produces a linearized and modified ligation product.

  提供了改进的天然化学连接方法。该方法涉及在温和条件下，无需使用保护基，也无需要求连接产物中存在半胱氨酸残基，将硫酸（例如肽硫酸）与环氧丙烷化合物（例如环氧丙烷肽）反应。硫酸和环氧丙烷化合物的初始偶联产生一个含有环氧丙烷环的连接产物。随后通过亲核攻击等方式打开环氧丙烷环，产生线性化和改性的连接产物。