2-(Acetylmethylene)-N-(pent-2-en-3-yl)-2,3-dihydro-1,3-benzothiazole | 135714-76-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(Acetylmethylene)-N-(pent-2-en-3-yl)-2,3-dihydro-1,3-benzothiazole
• 英文别名: (1Z)-1-[3-[(Z)-pent-2-en-3-yl]-1,3-benzothiazol-2-ylidene]propan-2-one
• CAS: 135714-76-0
• 化学式: C₁₅H₁₇NOS
• 分子量: 259.372
• InChiKey: UCRIXLOFMXFIFB-BHPWTJDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-acetyl-2,2-diethyl-2,3-dihydro-benzothiazole 、 乙酸酐 反应 100.0h， 以13%的产率得到2-(Acetylmethylene)-N-(pent-2-en-3-yl)-2,3-dihydro-1,3-benzothiazole
  参考文献：
  名称：

  N-alkenyl acylketene S, N-acetals from 2,3-dihydro-1,3-benzothiazoles and carboxylic anhydrides. X-Ray molecular structure of 2-(butyrylmethylene)N-(cyclohex-1-enyl)-2,3-dihydro-1,3-benzothiazole

  摘要：

  Depending on the reaction conditions or starting materials used, 2,3-dihydro-1,3-benzothiazoles 1 or their N-acyl derivatives 2 react with carboxylic anhydrides to yield the corresponding enamides 3 and/or N-alkenyl acylketene S,N-acetals 4. The structural assignments of these last compounds are based on spectroscopic data. X-Ray evidence for title compound 4c is also reported. A possible reaction pathway for formation of products 4 is suggested.

  DOI：

  10.1039/p19910001505

文献信息

• Modulators of CDC2-like kinases (CLKS) and methods of use thereof
  申请人：Milne Jill

  公开号：US20070248590A1

  公开（公告）日：2007-10-25

  Provided herein are methods for using Cdc2-like kinase (Clk) modulators for treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, ocular disorders, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a Clk modulating compound in combination with another therapeutic agent.

  本文提供了使用Cdc2-like kinase (Clk)调节剂治疗和/或预防各种疾病和障碍的方法，包括与衰老或压力有关的疾病或障碍、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝结障碍、炎症、癌症、眼部疾病和/或潮红，以及需要增加线粒体活动的疾病或障碍。此外，提供了包含Clk调节化合物与另一种治疗剂联合使用的组合物。
• N-alkenyl acylketene S, N-acetals from 2,3-dihydro-1,3-benzothiazoles and carboxylic anhydrides. X-Ray molecular structure of 2-(butyrylmethylene)N-(cyclohex-1-enyl)-2,3-dihydro-1,3-benzothiazole
  作者：Giuseppe Trapani、Andrea Latrofa、Antonia Reho、Massimo Franco、Gaetano Liso、Francesca Stasi

  DOI：10.1039/p19910001505

  日期：——

  Depending on the reaction conditions or starting materials used, 2,3-dihydro-1,3-benzothiazoles 1 or their N-acyl derivatives 2 react with carboxylic anhydrides to yield the corresponding enamides 3 and/or N-alkenyl acylketene S,N-acetals 4. The structural assignments of these last compounds are based on spectroscopic data. X-Ray evidence for title compound 4c is also reported. A possible reaction pathway for formation of products 4 is suggested.