((6-chlorohexyloxy)methanetriyl)tribenzene | 52517-96-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: ((6-chlorohexyloxy)methanetriyl)tribenzene
• 英文别名: 1-chloro-6-(triphenylmethoxy)hexane；1-chloro-6-triphenylmethoxyhexane；Benzene, 1,1',1''-[[(6-chlorohexyl)oxy]methylidyne]tris-；[6-chlorohexoxy(diphenyl)methyl]benzene
• CAS: 52517-96-1
• 化学式: C₂₅H₂₇ClO
• 分子量: 378.942
• InChiKey: XNCRHAYMYYEAGU-UHFFFAOYSA-N

物化性质

• 沸点：
  477.0±33.0 °C(Predicted)
• 密度：
  1.083±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  sodium;hydride 、 N,N-二甲基甲酰胺 、 、 ((6-chlorohexyloxy)methanetriyl)tribenzene 在 氢气 、 乙醚 、 水 、 magnesium sulfate 、 silica gel 作用下， 以 水 为溶剂， 反应 4.0h， 生成 3-[6-(triphenylmethoxy)hexyloxy]-2-methylenepropan-1-ol
  参考文献：
  名称：

  Novel propane-1,3-diol derivatives and use

  摘要：

  该化合物的普遍式I为：##STR1## 其中O-A.sup.1和O-A.sup.2可以相同也可以不同，每个代表O，O-C（O），O-C（O）NH，O-C（S）NH或O-C（O）O，R.sup.1代表10-22个碳原子的烷基或烯基，n为1至11的整数，B.sup.+代表季铵基，可以是N.sup.+R.sup.4R.sup.5R.sup.6或N.sup.+(Het)，其中R.sup.4，R.sup.5和R.sup.6是相似或不同的1-4个碳原子的烷基，或者其中两个或全部可以并入环状或双环结构中，其中可能含有其他杂原子；X.sup.-表示药学上可接受的无机或有机酸的阴离子；R.sup.2和R.sup.3相同或不同，代表氢或1-4个碳原子的烷基。这些化合物已被证明具有PAF拮抗作用和抑制肿瘤细胞生长的作用，在人类和兽医实践中非常有价值，可用作血小板聚集抑制剂，抗血栓剂，抗哮喘剂，抗过敏剂，抗炎剂，抗低血压剂，抗溃疡剂，抗银屑病剂，抗移植排斥剂，抗避孕剂和抗肿瘤剂。

  公开号：

  US04945098A1
• 作为产物：
  描述：

  6-氯-1-己醇 、 三苯基氯甲烷 在 吡啶 作用下， 反应 1.0h， 以74%的产率得到((6-chlorohexyloxy)methanetriyl)tribenzene
  参考文献：
  名称：

  Mild and Adaptable Silver Triflate-Assisted Method for Trityl Protection of Alcohols in Solution with Solid-Phase Loading Applications

  摘要：

  Trityl ethers were prepared in solution in a matter of minutes by treating trityl chloride with silver triflate in the presence of alcohols. Yields were comparable or better than known literature methods. The method was compatible with the base-labile Fmoc protecting group of amino alcohols and adapted for trityl protection of halo-containing alcohols. These base- and nucleophile-sensitive intermediates were anchored on trityl resin and further functionalized, displaying the utility of this approach for future combinatorial applications.

  DOI：

  10.1021/ol0614018

文献信息

• Hydroxylated 15-deoxy derivatives of 9-hydroxy-13-trans-prostenoic acid
  申请人：American Cyanamid Company

  公开号：US03950406A1

  公开（公告）日：1976-04-13

  This disclosure describes certain 15-deoxy prostanoic acid derivatives having a hydroxy group further along in the beta-chain, useful as bronchodilators, hypotensive agents, anti-ulcer agents, or as intermediates.

  本披露描述了某些具有β-链中进一步的羟基的15-去氧前列腺酸衍生物，可用作支气管扩张剂、降压剂、抗溃疡剂或中间体。
• Novel hydroxy substituted 15-deoxy-5-cis-prostenoic acids and esters
  申请人：American Cyanamid Company

  公开号：US04179451A1

  公开（公告）日：1979-12-18

  This disclosure describes certain hydroxy substituted 15-deoxy-5-cis-prostenoic acids and esters useful as hypotensive agents, anti-ulcer agents, bronchodilators, anti-microbial agents, anticonvulsants, or as intermediates.

  本文披露了某些羟基取代的15-去氧-5-顺式前列腺酸及其酯类，可用作降压剂、抗溃疡剂、支气管扩张剂、抗微生物剂、抗癫痫剂或中间体。
• Novel propane-1,3-diol derivatives and use
  申请人：Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik

  公开号：US04945098A1

  公开（公告）日：1990-07-31

  A derivative of 2-methylenepropane-1,3-diol of the general formula I ##STR1## where O--A.sup.1 and O--A.sup.2, which can be the same or different, each represents O, O--C(O), O--C(O)NH, O--C(S)NH or O--C(O)O, R.sup.1 represents an alkyl or alkenyl group of 10-22 carbon atoms, n is an integer from 1 to 11, B.sup.+ represents a quaternary ammonium group, either N.sup.+ R.sup.4 R.sup.5 R.sup.6, or N.sup.+ (Het), where R.sup.4, R.sup.5 and R.sup.6 are similar or different alkyl groups of 1-4 carbon atoms, or two or all of R.sup.4, R.sup.5 and R.sup.6 may be incorporated into a cyclic or bicyclic structure, which may contain additional hetero atoms; X.sup.- means the anion of a pharmceutically acceptable inorganic or organic acid; and R.sup.2 and R.sup.3 are the same or different, and represent hydrogen or alkl groups of 1-4 carbon atoms. The present compounds have been shown to possess a PAF antagonistic effect and an inhibitory effect on the growth of tumor cells, and are thus valuable in the human and veterinary practice as platelet aggregation inhibitors, anti-thrombotic agents, anti-asthmatic agents, anti-allergic agents, anti-inflammatory agents, anti-hypotensive agents, anti-ulcer agents, anti-psoriatic agents, anti-graft rejection agents, anti-conception agents and anti-tumor agents.

  该化合物的普遍式I为：##STR1## 其中O-A.sup.1和O-A.sup.2可以相同也可以不同，每个代表O，O-C（O），O-C（O）NH，O-C（S）NH或O-C（O）O，R.sup.1代表10-22个碳原子的烷基或烯基，n为1至11的整数，B.sup.+代表季铵基，可以是N.sup.+R.sup.4R.sup.5R.sup.6或N.sup.+(Het)，其中R.sup.4，R.sup.5和R.sup.6是相似或不同的1-4个碳原子的烷基，或者其中两个或全部可以并入环状或双环结构中，其中可能含有其他杂原子；X.sup.-表示药学上可接受的无机或有机酸的阴离子；R.sup.2和R.sup.3相同或不同，代表氢或1-4个碳原子的烷基。这些化合物已被证明具有PAF拮抗作用和抑制肿瘤细胞生长的作用，在人类和兽医实践中非常有价值，可用作血小板聚集抑制剂，抗血栓剂，抗哮喘剂，抗过敏剂，抗炎剂，抗低血压剂，抗溃疡剂，抗银屑病剂，抗移植排斥剂，抗避孕剂和抗肿瘤剂。
• Blueberry plant named ‘Ridley 4609’
  申请人：Mountain Blue Orchards Pty Ltd.

  公开号：USPP029469P3

  公开（公告）日：2018-07-10

  The new blueberry plant variety ‘RIDLEY 4609’ is provided. The variety is produced from a cross of ‘C95-152’ (unpatented) and pollen parent ‘C00-09’ (U.S. Plant Pat. No. 22,778), which can be distinguished by its outstanding features.

  提供了新的蓝莓植物品种“ RIDLEY 4609”。该品种是由“ C95-152”（未受专利保护）和花粉亲本“ C00-09”（美国植物专利号22,778）的交叉产生的，可以通过其突出的特征来区分。
• Derivatives of 9-hydroxy-13-trans-prostenoic acid
  申请人：American Cyanamid Company

  公开号：US04061672A1

  公开（公告）日：1977-12-06

  This disclosure describes certain 15-deoxy prostanoic acid derivatives having a hydroxy group further along in the beta-chain, useful as bronchodilators, hypotensive agents, anti-ulcer agents, or as intermediates.

  本公开说明了某些15-去氧前列腺酸衍生物，其在β-链中进一步具有羟基，可用作支气管扩张剂、降压剂、抗溃疡剂或中间体。