N-(2-(methylamino)ethyl)-N,N',N'-trimethylsulfamide | 1035587-64-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: N-(2-(methylamino)ethyl)-N,N',N'-trimethylsulfamide
• 英文别名: N'-(dimethylsulfamoyl)-N,N'-dimethylethane-1,2-diamine
• CAS: 1035587-64-4
• 化学式: C₆H₁₇N₃O₂S
• 分子量: 195.286
• InChiKey: DYSJQYOLOYVISW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(2-(methylamino)ethyl)-N,N',N'-trimethylsulfamide 、 4-氯-2-甲氧基甲基嘧啶 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 以95%的产率得到N-(2-[N''-(2-(methoxymethyl)pyrimidin-4-yl)-N''-(methyl)amino]ethyl)-N,N',N'-trimethylsulfamide
  参考文献：
  名称：

  Synthesis and Biological Evaluations of New Pyrrolo[2,3-b]pyrimidine as SDI Analogs

  摘要：

  The synthesis of new pyrrolo[2,3-d]pyrimidines variously substituted on the N-1 and C-2 atoms are described. Access to these compounds, which have modest activity compared with the first inhibitor SDI, involves, as the key step, the formation of a pyrrolopyrimidine skeleton from the 5-amino-2-(methoxymethyl)pyrimidine.

  DOI：

  10.3987/com-07-11302
• 作为产物：
  描述：

  二甲胺基磺酰氯 、 N,N'-二甲基乙二胺 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 0.67h， 以66%的产率得到N-(2-(methylamino)ethyl)-N,N',N'-trimethylsulfamide
  参考文献：
  名称：

  Synthesis and Biological Evaluations of New Pyrrolo[2,3-b]pyrimidine as SDI Analogs

  摘要：

  The synthesis of new pyrrolo[2,3-d]pyrimidines variously substituted on the N-1 and C-2 atoms are described. Access to these compounds, which have modest activity compared with the first inhibitor SDI, involves, as the key step, the formation of a pyrrolopyrimidine skeleton from the 5-amino-2-(methoxymethyl)pyrimidine.

  DOI：

  10.3987/com-07-11302

文献信息

• Surfaces that resist the adsorption of biological species
  申请人：Chapman G. Robert

  公开号：US20070264505A1

  公开（公告）日：2007-11-15

  The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

  本发明提供了一种对蛋白质、细胞和细菌吸附具有抗性的物品。这些物品可以在其上具有化学链，其中化学链可以包括一个不含氢键供体的末端基团，或者氢键供体被足够埋藏，以使包括化学链的暴露表面不含氢键供体。化学链或多种化学链可以包括单层，例如自组装单层（SAM），它可以是均质的（一种SAM）或混合的，即多种不同类型的SAM。还提供了其他更具体的化学链的例子。多种化学链可以包括聚合物，例如聚胺。在许多方面，多种化学链足够不含交联或分支。本发明还提供了一种物品，能够特异性结合所需生物分子，同时防止非特异性生物分子结合。
• US7276286B2
  申请人：——

  公开号：US7276286B2

  公开（公告）日：2007-10-02
• US7494714B2
  申请人：——

  公开号：US7494714B2

  公开（公告）日：2009-02-24