pentyl-(7(9)H-purin-6-yl)-amine | 14671-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: pentyl-(7(9)H-purin-6-yl)-amine
• 英文别名: N-pentyl-7H-purin-6-amine
• CAS: 14671-26-2
• 化学式: C₁₀H₁₅N₅
• 分子量: 205.263
• InChiKey: CBTKZTIKRZICIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-氨基戊烷 、 6-甲巯基嘌呤 生成 pentyl-(7(9)H-purin-6-yl)-amine
  参考文献：
  名称：

  Effects of Some 6-(Substituted)-purines on Regeneration of Hydra

  摘要：

  DOI：

  10.1021/ja01600a075

文献信息

• [EN] METHODS FOR IDENTIFYING INHIBITORS OF "STIMULATOR OF INTERFERON GENE"-DEPENDENT INTERFERON PRODUCTION<br/>[FR] PROCÉDÉS SERVANT À IDENTIFIER DES INHIBITEURS DE LA PRODUCTION D'INTERFÉRON DÉPENDANT DU STIMULATEUR DU GÈNE D'INTERFÉRON
  申请人：ADURO BIOTECH INC

  公开号：WO2017106740A1

  公开（公告）日：2017-06-22

  The present invention relates to the use cyclic-di-nucleotide and related scaffold molecules that measurably inhibit STING signaling, and methods for their use in identifying more potent inhibitors of STING signaling. In particular, the methods provided can be used to identify potent inhibitors of STING signaling, which are useful in the treatment of autoimmune and inflammatory diseases. Also provided are compounds having STING inhibitory activity useful in the treatment of autoimmune and inflammatory diseases.

  本发明涉及使用环二核苷酸和相关支架分子来可测地抑制STING信号传导的方法，以及利用这些方法来鉴定更强效的STING信号传导抑制剂的方法。具体而言，所提供的方法可用于鉴定强效的STING信号传导抑制剂，这些抑制剂在治疗自身免疫和炎症性疾病方面非常有用。同时还提供了具有STING抑制活性的化合物，可用于治疗自身免疫和炎症性疾病。
• Methods For Selective N-9 Glycosylation of Purines
  申请人：Robins Morris J.

  公开号：US20080207891A1

  公开（公告）日：2008-08-28

  A process for providing regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs is described. The introduction of the sugar moiety on to 6-(azolyl)-substituted purine bases is performed so that highly stereoselective formation of the β anomers of only the 9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs, and in particular 2′-deoxy, 3′-deoxy, 2′-deoxy-2′-halo-arabino and 2′,3′-dideoxy-2′-halo-threo purine nucleoside analogs, in high yields without formation of the 7-positional regioisomers. Processes for providing novel 6-(azolyl)purines for the regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs are described. The compounds are drugs or intermediates to drugs.

  本文描述了一种提供9-β异构嘌呤核苷类似物的区域特异性和高度立体选择性合成的方法。将糖基引入到6-(咪唑基)-取代的嘌呤碱基上，以获得嘌呤核苷类似物的β异构体的高度立体选择性形成（D或L对映体）。这种区域特异性和立体选择性引入糖基的方法，允许高产率地合成核苷类似物，特别是2'-去氧、3'-去氧、2'-去氧-2'-卤代阿拉伯糖和2',3'-二去氧-2'-卤代-threo嘌呤核苷类似物，而不形成7位异构体。本文还描述了提供新型6-(咪唑基)嘌呤用于区域特异性和高度立体选择性合成9-β异构嘌呤核苷类似物的方法。这些化合物是药物或药物中间体。
• Fluorine containing cyclopentane derivatives and processes for their production
  申请人：ASAHI GLASS COMPANY LTD.

  公开号：EP0277599A2

  公开（公告）日：1988-08-10

  A 1β-substituted-2-hydroxy(or unsubstituted)-3­(or 4)-fluoro-4β-hydroxymethyl cyclopentane derivative having the formula: wherein B is a residue of a nucleic acid base, an azido group, an amino group or an amino group protected by a protecting group; R¹ is a hydrogen atom or a hydroxyl-protecting group; and X is a hydrogen atom or -OR² wherein R² is a hydrogen atom or a hydroxyl-protecting group, provided that the fluorine atom F is present at the 3α-, 3β- or 4α-position.

  一种 1β-取代-2-羟基（或未取代）-3（或 4）-氟-4β-羟甲基环戊烷衍生物，其式为： 其中 B 是核酸碱基残基、叠氮基、氨基或受保护基保护的氨基；R¹ 是氢原子或羟基保护基；X 是氢原子或-OR²，其中 R² 是氢原子或羟基保护基，条件是氟原子 F 存在于 3α-、3β 或 4α 位。
• Effects of Some 6-(Substituted)-purines on Regeneration of Hydra
  作者：Charles G. Skinner、William Shive、Richard G. Ham、David C. Fitzgerald、Robert E. Eakin

  DOI：10.1021/ja01600a075

  日期：1956.10
• METHODS FOR SELECTIVE N-9 GLYCOSYLATION OF PURINES
  申请人：Brigham Young University

  公开号：EP1895841A2

  公开（公告）日：2008-03-12