acetic acid (6'-methoxy-spiro-isobenzofuran-1(3H),9'(9'H)-xanthen-3-one)-3'-yl ester | 7262-43-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: acetic acid (6'-methoxy-spiro-isobenzofuran-1(3H),9'(9'H)-xanthen-3-one)-3'-yl ester
• 英文别名: 3'-acetoxy-6'-methoxy-spiro[phthalan-1,9'-xanthen]-3-one；3'-Acetoxy-6'-methoxy-spiro[phthalan-1,9'-xanthen]-3-on；(6'-Methoxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate
• CAS: 7262-43-3
• 化学式: C₂₃H₁₆O₆
• 分子量: 388.376
• InChiKey: ZCBFBAGBQZGXDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙酸酐 作用下， 生成 acetic acid (6'-methoxy-spiro-isobenzofuran-1(3H),9'(9'H)-xanthen-3-one)-3'-yl ester
  参考文献：
  名称：

  Alkenyl Derivatives of Fluorescein

  摘要：

  DOI：

  10.1021/ja01280a027

文献信息

• Fluorogenic ester substrates to assess proteolytic activity
  作者：Laurent Mugherli、Olga N. Burchak、François Chatelain、Maxim Y. Balakirev

  DOI：10.1016/j.bmcl.2006.06.037

  日期：2006.9

  The synthesis of a new type of fluorogenic ester substrates is described. Prepared from fluorescein in three steps with common commercially available precursors, they all generate bright green fluorescence upon proteolysis. Their particular structure allows the same substrate be used to report enzymatic activity of various proteases from serine and cysteine superfamilies. The substrate cleavage is sensitive to specific protease inhibitors providing a tool for inhibitor screening. (c) 2006 Elsevier Ltd. All rights reserved.
• POLYMER, COMPOSITION, MOLDED ARTICLE, CURED PRODUCT, AND LAMINATE
  申请人：JSR CORPORATION

  公开号：US20190169362A1

  公开（公告）日：2019-06-06

  A polymer, includes a first structural unit represented by formula (1), a second structural unit represented by formula (2-1), formula (2-2), or both, and a third structural unit represented by formula (3-1), formula (3-2), or both. The polymer preferably has a weight-average molecular weight in terms of polystyrene of 500 or more and 400,000 or less. A composition includes the polymer and an organic solvent. A molded body includes the polymer.
• Alkenyl Derivatives of Fluorescein
  作者：Charles D. Hurd、Louis Schmerling

  DOI：10.1021/ja01280a027

  日期：1937.1