Methyl-bis-(β,β,β-trichlorethyl)-phosphonat | 683-14-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Methyl-bis-(β,β,β-trichlorethyl)-phosphonat
• 英文别名: Methylphosphonsaeure-bis-(2,2,2-trichlor-ethylester)；Phosphonic acid, methyl-, bis(2,2,2-trichloroethyl) ester；1,1,1-trichloro-2-[methyl(2,2,2-trichloroethoxy)phosphoryl]oxyethane
• CAS: 683-14-7
• 化学式: C₅H₇Cl₆O₃P
• 分子量: 358.801
• InChiKey: AHQLEJSNBWNSBD-UHFFFAOYSA-N

物化性质

• 熔点：
  63.0-63.5 °C
• 沸点：
  335.2±42.0 °C(Predicted)
• 密度：
  1.658±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2,2-三氯乙醇 、 甲基二氯膦 生成 Methyl-bis-(β,β,β-trichlorethyl)-phosphonat
  参考文献：
  名称：

  Kinetics and mechanism of the reaction of Δ³-phospholens with diethyl peroxide

  摘要：

  DOI：

  10.1039/p29770000882

文献信息

• Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
  申请人：Pettit R. George

  公开号：US20070073077A1

  公开（公告）日：2007-03-29

  Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as “Combretastatin A-4 Prodrugs”.
• SYNTHESIS OF COMBRETASTATIN A-4 PRODRUGS AND TRANS-ISOMERS THEREOF
  申请人：Pettit George R.

  公开号：US20080146528A1

  公开（公告）日：2008-06-19

  Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as “Combretastatin A-4 Prodrugs”.
• Carbapenem Compound
  申请人：Kajita Satoshi

  公开号：US20090143574A1

  公开（公告）日：2009-06-04

  The present invention relates to a carbapenem compound represented by formula (Ia) shown below: The carbapenem compound preferably has a crystalline form, and more preferably, the crystalline form has a powder X-ray diffraction pattern with peaks at 15.64, 9.93, 6.83, 6.52, 5.44, 5.01, 4.72, 4.50, 4.33, 4.24, 3.98, 3.85, 3.57, 3.41, 3.31, 3.10 2.76, and 2.67 as d-spacings (Å).
• US7279466B2
  申请人：——

  公开号：US7279466B2

  公开（公告）日：2007-10-09
• US7557096B2
  申请人：——

  公开号：US7557096B2

  公开（公告）日：2009-07-07