N-Benzyl-N'-(benzthiazol-2-yl)-thioharnstoff | 34989-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-Benzyl-N'-(benzthiazol-2-yl)-thioharnstoff
• 英文别名: 1-benzothiazol-2-yl-3-benzyl-thiourea；1-(1,3-Benzothiazol-2-yl)-3-benzylthiourea
• CAS: 34989-74-7
• 化学式: C₁₅H₁₃N₃S₂
• mdl: MFCD04181504
• 分子量: 299.42
• InChiKey: PXQRFYZBYSUMET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.066
• 拓扑面积：
  97.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-Benzyl-N'-(benzthiazol-2-yl)-thioharnstoff 在 氨 、 lead(II) oxide 作用下， 以 乙醇 为溶剂， 生成 N-Benzyl-N'-(benzthiazol-2-yl)-guanidin
  参考文献：
  名称：

  Bhargava,P.N.; Devi,K.S., Journal of the Indian Chemical Society, 1963, vol. 40, p. 868 - 870

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基苯并噻唑 、 异硫氰酸苯甲酯 以 苯 为溶剂， 以55%的产率得到N-Benzyl-N'-(benzthiazol-2-yl)-thioharnstoff
  参考文献：
  名称：

  Synthesis and antimicrobial activity of 1-aryl-2-amino-3-(4-arylthiazol-2-yl)/(benzothiazol-2-yl)guanidines

  摘要：

  The synthesis of fifteen new 1-aryl-2-amino-3-(4-arylthiazol-2-yl)/(benzothiazol-2-yl)guanidines is described. They were screened for their antimicrobial susceptibility by the standard disc diffusion method of the World Health Organization (WHO) and the activities compared with that of standard strain of Escherichia coli NCTC 10418. The sensitive aminoguanidines were further subjected to the minimum inhibitory concentration (MIC) test. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(00)00032-x

文献信息

• Half sandwich platinum group metal complexes of thiourea derivative ligands with benzothiazole moiety possessing anti-bacterial activity and colorimetric sensing: Synthesis and characterisation
  作者：Lathewdeipor Shadap、Siewdorlang Diamai、Venkanna Banothu、D.P.S. Negi、Uma Adepally、Werner Kaminsky、Mohan Rao Kollipara

  DOI：10.1016/j.jorganchem.2019.01.019

  日期：2019.3

  Complexes 1–9 were prepared by the reaction of [(arene)MCl2]2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) with thiourea derivative ligands L1, L2 and L3. These complexes have been isolated as cationic bidentate (N, S), neutral bidentate (N, S) as well as neutral mono-dentate (S) complexes. Anti-bacterial activity studies were carried out for these complexes as well as the ligands against Gram-positive

  配合物1–9是通过[[arene）MCl 2 ] 2（芳烃= 对甲基异丙基苯，Cp *； M = Ru，Rh和Ir）与硫脲衍生物配体L1，L2和L3反应制得的。这些配合物已被分离为阳离子双齿（N，S），中性双齿（N，S）以及中性单齿（S）配合物。对这些复合物以及针对革兰氏阳性菌（金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌；肺炎克雷伯菌）的配体进行了抗菌活性研究，其中所有复合物（复合物2和3除外）6）以及配体（L3除外）均表现出抗菌活性。除了生物学研究，还进行了使用银纳米粒子的比色传感研究，其中配体L1和L3表现出团聚作用。
• Bhargava,P.N.; Devi,K.S., Journal of the Indian Chemical Society, 1963, vol. 40, p. 868 - 870
  作者：Bhargava,P.N.、Devi,K.S.

  DOI：——

  日期：——
• Synthesis and antimicrobial activity of 1-aryl-2-amino-3-(4-arylthiazol-2-yl)/(benzothiazol-2-yl)guanidines
  作者：Ram Lakhan、Bimal Prasad Sharma、Bishwa Nath Shukla

  DOI：10.1016/s0014-827x(00)00032-x

  日期：2000.5

  The synthesis of fifteen new 1-aryl-2-amino-3-(4-arylthiazol-2-yl)/(benzothiazol-2-yl)guanidines is described. They were screened for their antimicrobial susceptibility by the standard disc diffusion method of the World Health Organization (WHO) and the activities compared with that of standard strain of Escherichia coli NCTC 10418. The sensitive aminoguanidines were further subjected to the minimum inhibitory concentration (MIC) test. (C) 2000 Elsevier Science S.A. All rights reserved.