2-[4-(2-巯基乙基)-1-哌嗪基]乙醇 | 42302-15-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 2-[4-(2-巯基乙基)-1-哌嗪基]乙醇
• 英文名称: 4-hydroxyethyl-piperazinylethanethiol
• 英文别名: 2-(4-(2-mercaptoethyl)piperazin-1-yl)ethan-1-ol；4-(2-Mercaptoethyl)-piperazin-1-ethanol；(4-Hydroxyethyl-piperazino)-ethan-thiol；2-[4-(2-mercapto-ethyl)-piperazin-1-yl]-ethanol；2-[4-(2-Sulfanylethyl)piperazin-1-yl]ethanol
• CAS: 42302-15-8
• 化学式: C₈H₁₈N₂OS
• 分子量: 190.31
• InChiKey: KFTLKVZINRHGCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[4-(2-巯基乙基)-1-哌嗪基]乙醇 在 4-二甲氨基吡啶 、 氟化氢吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 32.25h， 生成 5-(bis(2-hydroxydecyl)amino)pentanoic acid 2-(4-(2-((5-(bis(2-hydroxydecyl)amino)pentanoyl)thio)ethyl)piperazin-1-yl)ethyl ester
  参考文献：
  名称：

  [EN] "GOOD"BUFFER-BASED CATIONIC LIPIDS
  [FR] "BONS" LIPIDES CATIONIQUES À BASE DE SUBSTANCE TAMPON

  摘要：

  The present invention provides, among other things, a novel class of cationic lipid compounds (e.g., cationic lipids having a structure according to Formula (I)) forin vivodelivery of therapeutic agents, such as nucleic acids. It is contemplated that these compounds are capable of highly effectivein vivodelivery while maintaining a favorable toxicity profile.

  公开号：

  WO2022221688A1
• 作为产物：
  描述：

  环硫乙烷 、 N-羟乙基哌嗪 以 甲苯 为溶剂， 生成 2-[4-(2-巯基乙基)-1-哌嗪基]乙醇
  参考文献：
  名称：

  [EN] "GOOD"BUFFER-BASED CATIONIC LIPIDS
  [FR] "BONS" LIPIDES CATIONIQUES À BASE DE SUBSTANCE TAMPON

  摘要：

  The present invention provides, among other things, a novel class of cationic lipid compounds (e.g., cationic lipids having a structure according to Formula (I)) forin vivodelivery of therapeutic agents, such as nucleic acids. It is contemplated that these compounds are capable of highly effectivein vivodelivery while maintaining a favorable toxicity profile.

  公开号：

  WO2022221688A1

文献信息

• [EN] PYRROLE DERIVATIVES AS ALPHA 7 NACHR MODULATORS<br/>[FR] DÉRIVÉS DE PYRROLE UTILISÉS COMME MODULATEURS DES RÉCEPTEURS NICOTINIQUES À L'ACÉTYLCHOLINE (NACHR) ALPHA-7
  申请人：LUPIN LTD

  公开号：WO2014141091A1

  公开（公告）日：2014-09-18

  Disclosed are compounds of the Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and m are as described herein, as modulators of the nicotinic acetylcholine receptors, particularly the α7 subtype, their tautomeric forms, stereoisomers, and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and combinations thereof with suitable other medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and/or treatment of disorders such as Alzheimer's disease, mild cognitive impairment, and senile dementia.

  本发明涉及化合物的公式（I），其中R1，R2，R3，R4，R5，R6，R7和m如本文所述，作为尼古丁酸乙酰胆碱受体的调节剂，特别是α7亚型，它们的互变异构体，立体异构体及其药学上可接受的盐，制药组合物以及与适当的其他药物的组合物。还公开了化合物的制备过程以及它们在治疗中的预期用途，特别是在预防和/或治疗阿尔茨海默病，轻度认知障碍和老年性痴呆等疾病中的应用。
• Neuropharmacological profile of 1-azaphenothiazine-10-thiolcarboxylates
  作者：Edward R. Atkinson、Pamela L. Russ、Margaret A. Tucker、Franklin J. Rosenberg

  DOI：10.1021/jm00292a038

  日期：1971.10
• Meingassner; Nesvadba; Mieth, Arzneimittel-Forschung/Drug Research, 1981, vol. 31, # 1, p. 6 - 8
  作者：Meingassner、Nesvadba、Mieth

  DOI：——

  日期：——
• PYRROLE DERIVATIVES AS ALPHA 7 NACHR MODULATORS
  申请人：Lupin Limited

  公开号：EP2970180A1

  公开（公告）日：2016-01-20
• LIPID NANOPARTICLES FOR DELIVERING mRNA VACCINES
  申请人：SANOFI

  公开号：US20220142923A1

  公开（公告）日：2022-05-12

  Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.