1-isopropyl-3,4-dipropylisoquinoline | 1257846-48-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-isopropyl-3,4-dipropylisoquinoline
• 英文别名: 1-Propan-2-yl-3,4-dipropylisoquinoline；1-propan-2-yl-3,4-dipropylisoquinoline
• CAS: 1257846-48-2
• 化学式: C₁₈H₂₅N
• 分子量: 255.403
• InChiKey: DZVLJDDIOPXTIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异丁酰苯 在 吡啶 、 4-二甲氨基吡啶 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 盐酸羟胺 、 copper diacetate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 1-isopropyl-3,4-dipropylisoquinoline
  参考文献：
  名称：

  Cu-Rh双金属中继催化剂由芳基酮O-乙酰氧基肟和内部炔烃合成氮杂环杂环化合物

  摘要：

  利用Cu（OAc）2- [Cp * RhCl 2 ] 2双金属催化体系，开发了一种由芳基酮O-乙酰基肟和内部炔烃合成氮杂杂环的方法。该反应在具有广泛取代基的肟的反-和顺-异构体上进行。Cu-Rh双金属系统可用于合成异喹啉以及β-咔啉，呋喃[2.3- c ]吡啶，吡咯并[2,3- c ]吡啶和噻吩并[2,3- c ]吡啶衍生物。

  DOI：

  10.1021/jo200897q

文献信息

• Rhodium(III)-Catalyzed Synthesis of Isoquinolines from Aryl Ketone<i>O</i>-Acyloxime Derivatives and Internal Alkynes
  作者：Pei Chui Too、Yi-Feng Wang、Shunsuke Chiba

  DOI：10.1021/ol102504b

  日期：2010.12.17

  isoquinolines from aryl ketone O-acyloxime derivatives and internal alkynes has been developed using [Cp*RhCl2]2−NaOAc as the potential catalyst system. The present transformation is carried out by a redox-neutral sequence of C−H vinylation via ortho-rhodation and C−N bond formation of the putative vinyl rhodium intermediate on the oxime nitrogen, where the N−O bond of oxime derivatives could work as an internal

  利用[Cp * RhCl 2 ] 2 -NaOAc作为潜在的催化剂体系，开发了一种由芳基酮O-酰基肟衍生物和内部炔烃合成异喹啉的方法。目前的转化是通过肟化氮的氧化还原-中性序列，通过肟基氮上的假定铑乙烯基中间体在邻位上的邻位R-rhodation和C-N键形成的，其中肟衍生物的N-O键可以用作内部氧化剂以维持催化循环。
• Synthesis of Azaheterocycles from Aryl Ketone <i>O</i>-Acetyl Oximes and Internal Alkynes by Cu–Rh Bimetallic Relay Catalysts
  作者：Pei Chui Too、Sze Hui Chua、Siong Heng Wong、Shunsuke Chiba

  DOI：10.1021/jo200897q

  日期：2011.8.5

  A synthetic method for azaheterocycles from aryl ketone O-acetyl oximes and internal alkynes has been developed by using the Cu(OAc)2–[Cp*RhCl2]2 bimetallic catalytic system. The reactions proceeded with both of anti- and syn-isomers of oximes with a wide scope of substituents. The Cu–Rh bimetallic system could be applied for the synthesis of isoquinolines as well as β-carboline, furo[2.3-c]pyridine

  利用Cu（OAc）2- [Cp * RhCl 2 ] 2双金属催化体系，开发了一种由芳基酮O-乙酰基肟和内部炔烃合成氮杂杂环的方法。该反应在具有广泛取代基的肟的反-和顺-异构体上进行。Cu-Rh双金属系统可用于合成异喹啉以及β-咔啉，呋喃[2.3- c ]吡啶，吡咯并[2,3- c ]吡啶和噻吩并[2,3- c ]吡啶衍生物。
• C–H Activation Induced by Oxidative Addition of N–O Bonds in Oxime Esters: Formation of Rhodacycles and Cycloaddition with Alkynes
  作者：Takuya Shimbayashi、Kazuhiro Okamoto、Kouichi Ohe

  DOI：10.1021/acs.organomet.6b00311

  日期：2016.6.13

  The reaction of oxime esters with a rhodium(I) precursor to form five-membered rhodacycles via N-O bond cleavage followed by C-H bond activation has been investigated by isolating these complexes. Kinetic studies on the formation of rhodacycles show that the reversible oxidative addition of the N-O bond in the oxime ester to RhCl(PPh3)(3) occurs at room temperature. The E-isomer of the oxime ester was found to undergo rhodacycle formation faster than the Z-isomer, which suggests that the geometry of the oxime esters reflects the geometry of intermediates during C-H activation. The rhodacycle reacted with an alkyne to construct an isoquinoline ring in both stoichiometric and catalytic conditions, despite its basic stability in air, in moisture, and even during heating, which demonstrates the potential of the rhodacycle as an intermediate for further catalytic transformation of oxime esters.