2-amino-4-(benzyloxy)pteridin-7(8H)-one | 49560-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 2-amino-4-(benzyloxy)pteridin-7(8H)-one
• 英文别名: 2-amino-4-benzyloxy-8H-pteridin-7-one；2-amino-4-phenylmethoxy-8H-pteridin-7-one
• CAS: 49560-77-2
• 化学式: C₁₃H₁₁N₅O₂
• 分子量: 269.263
• InChiKey: QPEKAMWAWRKPNZ-UHFFFAOYSA-N

物化性质

• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-amino-4-(benzyloxy)pteridin-7(8H)-one 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of 8-(2-Deoxy-β-D-Ribofuranosyl)-Isoxanthopterins New Fluorescent Analogs of 2′-Deoxyguanosine

  摘要：

  We have synthesized isoxanthopterin and 6-phenylisoxanthopterin nucleosides in form of their 5'-O-dimethoxytritylated 3'-phosphoramidites to be used as fluorescence markers directly in the synthesis of oligonucleotides by a machine-aided solid-support approach. The preparation of the monomers and some results of the oligonucleotide synthesis will be described.

  DOI：

  10.1080/07328319708002965

文献信息

• Nucleotides, Part LXIX, Synthesis of Phosphoramidite Building Blocks of IsoxanthopterinN8-(2′-Deoxy-β-D-ribonucleosides): New Fluorescence Markers for Oligonucleotide Synthesis
  作者：Jörg Lehbauer、Wolfgang Pfleiderer

  DOI：10.1002/1522-2675(20010815)84:8<2330::aid-hlca2330>3.0.co;2-u

  日期：2001.8.15

  The chemical synthesis of isoxanthopterin and 6-phenylisoxanthopterin N-8-(2'-deoxy-beta -D-ribofuranosyl nucleosides) is described as well as their conversion into suitably protected 3'-phosphoramidite building blocks to be used as marker molecules for DNA synthesis. Applying the npe/npeoc (=2-(4-nitrophenyl)ethyl/[2-(4-nitrophenyl)ethoxy]carbonyl) strategy, we used the new building blocks in the preparation of oligonucleotides by an automated solid-support approach, The hybridization properties of a series of labelled oligomers were studied by UV-melting techniques. It was found that the newly synthesized markers only slightly interfered with the abilities of the labelled oligomers to form stable duplexes with complementary oligonucleotides.
• PTERIDINE NUCLEOTIDE ANALOGS AS FLUORESCENT DNA PROBES
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP0759927A1

  公开（公告）日：1997-03-05
• Nucleosides With Non-Natural Bases as Anti-Viral Agents
  申请人：Pierra Claire

  公开号：US20100279974A1

  公开（公告）日：2010-11-04

  A method and composition for treating a host infected with flavivirus, pestivirus or hepacivirus comprising administering an effective flavivirus, pestivirus or hepacivirus treatment amount of a described base-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
• US5525711A
  申请人：——

  公开号：US5525711A

  公开（公告）日：1996-06-11
• US5612468A
  申请人：——

  公开号：US5612468A

  公开（公告）日：1997-03-18