4-(diisopropylamino)pyridine | 85452-81-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(diisopropylamino)pyridine
• 英文别名: 4-isopropylaminopyridine；N,N-diisopropylpyridin-4-amine；DIAP；diisopropyl-pyridin-4-yl-amine；N,N-di(propan-2-yl)pyridin-4-amine
• CAS: 85452-81-9
• 化学式: C₁₁H₁₈N₂
• 分子量: 178.277
• InChiKey: JXFXNPBIVZKCKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-溴吡啶 、 lithium diisopropyl amide 生成 4-(diisopropylamino)pyridine
  参考文献：
  名称：

  MALLET, M.;QUEGUINER, G., TETRAHEDRON, 1982, 38, N 20, 3035-3042

  摘要：

  DOI：

文献信息

• [EN] COMPOSITION AND METHOD FOR NEUROPEPTIDE S RECEPTOR (NPSR) ANTAGONISTS<br/>[FR] COMPOSITION ET MÉTHODE POUR DES ANTAGONISTES DES RÉCEPTEURS DE NEUROPEPTIDE (NPSR)
  申请人：RES TRIANGLE INST

  公开号：WO2013086200A1

  公开（公告）日：2013-06-13

  Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.

  神经肽S受体拮抗剂在与神经肽S受体的功能分析中结合；提供了一种使用这些拮抗剂治疗通过阻断神经肽S受体而改善的状况或疾病状态的方法，包括物质滥用和物质滥用复吸；以及使用神经肽S受体拮抗剂在治疗疾病状态和条件中对神经肽S受体结合敏感的药物和前药的制造中的应用。
• Reaction de la bromo-3 pyridine avec le diisopropylamidure de lithium. Mecanismes de metallation et de migration d'halogene. Regioselectivite de l'addition polaire sur la pyridyne-3,4
  作者：M. Mallet、G. Quénguiner

  DOI：10.1016/0040-4020(82)80190-7

  日期：1982.1

  3-bromo pyridine behaviour towards lithium diisopropyl amide (LDA) in THF is studied. A careful study of the experimental conditions point to a metallation reaction in position 4 and a “halogen dance” mechanism with isomerisation into a 4-bromo pyridine. Conversion into diisopropylamino compounds occurs simultaneously with a 3 oriented elimination-addition (EA) reaction from transient isomeric lithio-derivatives

  研究了3-溴吡啶在THF中对二异丙基氨基锂（LDA）的行为。对实验条件的仔细研究指出了位置4的金属化反应和异构化成4-溴吡啶的“卤素舞”机理。转化为二异丙基氨基化合物的过程与瞬时异构体硫代衍生物的3向消除-加成（EA）反应和原位形成的4-溴吡啶的竞争加成-消除（AE）机理同时发生。
• COMPOSITION AND METHOD FOR NEUROPEPTIDE S RECEPTOR (NPSR) ANTAGONISTS
  申请人：RESEARCH TRIANGLE INSTITUTE

  公开号：US20150057268A1

  公开（公告）日：2015-02-26

  Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.

  本发明提供了与神经肽S受体在功能测定中结合的神经肽S受体拮抗剂；提供了使用这些拮抗剂治疗通过阻断神经肽S受体而改善的疾病状态或疾病的方法，包括物质滥用和物质滥用复发；以及使用神经肽S受体拮抗剂制造治疗剂和治疗剂的前药，对于疾病状态和对神经肽S受体结合敏感的情况有用。
• Cephalosporin intermediates and their preparation
  申请人：THE UPJOHN COMPANY

  公开号：EP0153874A2

  公开（公告）日：1985-09-04

  @ 3-(Activated ester)methyl-3-cephem 4-carboxylic acids are prepared by the direct reaction of a 3-hydroxymethyl-3-cephem-4-carboxylic acid with an activated-0-ester-methyl forming acylating agent, in the presence of a 4-(tertiary amino) pyridine catalyst and an acid-absorbing base, in a non-polar liquid solvent, at -78 to 30 C. Certain products of the reaction are novel.

  3- (活化酯)甲基-3-头孢-4-羧酸是通过 3-羟甲基-3-头孢-4-羧酸与活化的 0-酯甲基酰化剂在 4-(叔氨基)吡啶催化剂和吸酸碱存在下，在非极性液体溶剂中，于 -78 至 30 摄氏度下直接反应制备的。
• Method for production of t-butyl- 3-oxobutyrates and their use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0324418A2

  公开（公告）日：1989-07-19

  An advantageous method of industrial production of tert-butyl 3-oxobutylate, which is an useful intermediate for synthesis, characterized by reacting tert-butyl alcohol with diketene in the presence of 4-(tertiary amino) pyridine, and an industrially advantageous method of producing cephalosporin compounds or pharmaceutically acceptable salts thereof, using tert-butyl 3-oxobutylate as an intermediate.

  一种工业化生产 3-氧代丁酸叔丁酯（一种有用的合成中间体）的有利方法，其特征是在 4-（叔氨基）吡啶存在下，使叔丁醇与二乙烯反应，以及一种以 3-氧代丁酸叔丁酯为中间体生产头孢菌素化合物或其药学上可接受的盐的工业化有利方法。