Methyl 7-(3,5-dimethyl-4-hydroxyphenyl)-3-oxoheptanoate | 118630-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Methyl 7-(3,5-dimethyl-4-hydroxyphenyl)-3-oxoheptanoate
• 英文别名: methyl 7-(4-hydroxy-3,5-dimethylphenyl)-3-oxoheptanoate
• CAS: 118630-82-3
• 化学式: C₁₆H₂₂O₄
• 分子量: 278.348
• InChiKey: VWSYCXPJGGOCOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl 7-(3,5-dimethyl-4-hydroxyphenyl)-3-oxoheptanoate 在 zinc(II) chloride 、 silver(l) oxide 作用下， 以 二氯甲烷 为溶剂， 生成 3-(3,5-Dimethyl-4-hydroxyphenyl)-2-(methoxycarbonyl)-2-cyclohexen-1-one
  参考文献：
  名称：

  para-Quinone methide initiated cyclization reactions

  摘要：

  DOI：

  10.1021/ja00185a058
• 作为产物：
  描述：

  7-[4-(tert-Butyl-dimethyl-silanyloxy)-3,5-dimethyl-phenyl]-3-oxo-heptanoic acid methyl ester 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以91%的产率得到Methyl 7-(3,5-dimethyl-4-hydroxyphenyl)-3-oxoheptanoate
  参考文献：
  名称：

  Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions

  摘要：

  p-Quinone methides were found to be excellent electrophilic cyclization initiators for the formation of six-membered rings. Cyclizations to form five- and seven-membered rings were also studied. Oxidation of 2,6-disubstituted phenols with Ag2O afforded the corresponding quinone methides. A wide range of cyclization terminators/nucleophiles were found to be effective in the cyclizations, including: allylsilane, beta-keto esters, furan, pyrrole, indole, and a number of alkenes. The yields of the cyclizations were generally high.

  DOI：

  10.1021/jo00100a039

文献信息

• Angle Steven R., Arnaiz Damian O., Boyce James P., Frutos Rogelio P., Lou+, J. Org. Chem, 59 (1994) N 21, S 6322-6337
  作者：Angle Steven R., Arnaiz Damian O., Boyce James P., Frutos Rogelio P., Lou+

  DOI：——

  日期：——
• para-Quinone methide initiated cyclization reactions
  作者：Steven R. Angle、Kenneth D. Turnbull

  DOI：10.1021/ja00185a058

  日期：1989.2
• Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions
  作者：Steven R. Angle、Damian O. Arnaiz、James P. Boyce、Rogelio P. Frutos、Michael S. Louie、Heather L. Mattson-Arnaiz、Jon D. Rainier、Kenneth D. Turnbull、Wenjin Yang

  DOI：10.1021/jo00100a039

  日期：1994.10

  p-Quinone methides were found to be excellent electrophilic cyclization initiators for the formation of six-membered rings. Cyclizations to form five- and seven-membered rings were also studied. Oxidation of 2,6-disubstituted phenols with Ag2O afforded the corresponding quinone methides. A wide range of cyclization terminators/nucleophiles were found to be effective in the cyclizations, including: allylsilane, beta-keto esters, furan, pyrrole, indole, and a number of alkenes. The yields of the cyclizations were generally high.