2-amino-6-chloro-4-methyl-phenol | 862730-26-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-amino-6-chloro-4-methyl-phenol
• 英文别名: 2-Amino-6-chlor-4-methyl-phenol；5-Chlor-3-amino-4-oxy-toluol；5-Chlor-3-amino-4-oxy-1-methyl-benzol；6-Chlor-2-amino-p-kresol；2-amino-6-chloro-4-methylphenol
• CAS: 862730-26-5
• 化学式: C₇H₈ClNO
• mdl: MFCD09754410
• 分子量: 157.6
• InChiKey: BXZDSKCPOYLYSK-UHFFFAOYSA-N

物化性质

• 沸点：
  257.8±40.0 °C(Predicted)
• 密度：
  1.331±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-amino-6-chloro-4-methyl-phenol 在 吡啶 作用下， 生成 4-acetoxy-3-chloro-5-[1]naphthoylamino-toluene
  参考文献：
  名称：

  Raiford; Lankelma, Journal of the American Chemical Society, 1925, vol. 47, p. 1119

  摘要：

  DOI：
• 作为产物：
  描述：

  2-chloro-4-methyl-6-nitrophenol 在 氧化铂 氢气 、 silica gel 、 ethyl acetate n-hexane 作用下， 以 乙醇 为溶剂， 反应 72.0h， 以to give the title compound (2.49 g) as a brown oil的产率得到2-amino-6-chloro-4-methyl-phenol
  参考文献：
  名称：

  Carboxylic Acid Compounds and Use Thereof

  摘要：

  提供一种优越的URAT1活性抑制剂，用于治疗与尿酸有关的病理状况，如高尿酸血症、痛风结节、急性痛风性关节炎、慢性痛风性关节炎、痛风性肾脏病、泌尿道结石、肾功能障碍、冠心病、缺血性心脏病等。一种URAT1活性抑制剂，其含有以下式[1]所表示的化合物或其药学上可接受的盐或其溶剂化物作为活性成分：其中每个符号如规范中所定义。

  公开号：

  US20070197512A1

文献信息

• Carboxylic Acid Compounds and Use Thereof
  申请人：Inoue Teruhiko

  公开号：US20070197512A1

  公开（公告）日：2007-08-23

  Provision of a superior URAT1 activity inhibitor effective for the treatment and the like of a pathology involving uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary lithiasis, renal dysfunction, coronary heart disease, ischemic cardiac diseases and the like. A URAT1 activity inhibitor containing a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient: wherein each symbol is as defined in the specification.

  提供一种优越的URAT1活性抑制剂，用于治疗与尿酸有关的病理，如高尿酸血症、痛风石、急性痛风性关节炎、慢性痛风性关节炎、痛风性肾病、尿路结石、肾功能障碍、冠心病、缺血性心脏病等。 一种包含下式[1]所表示的化合物或其药学上可接受的盐，或其溶剂化合物的URAT1活性抑制剂作为活性成分： 其中每个符号如规范中定义。
• CONDENSED HETEROCYCLIC COMPOUND
  申请人：KASUMA PARTNERS INC.

  公开号：US20170298081A1

  公开（公告）日：2017-10-19

  A compound represented by the general formula (I) [R 1 represents a C 1-6 alkyl group, a halogen atom, or the like; A represents a phenylene group, or the like; X represents —CH(R 3 )—, —O—, —NH—, or the like; Y represents —O—, —NH—, —N═, or —S—; . . . represents a single bond or double bond; n represents 1 to 3; R 2 represents a C 1-6 alkyl group, a C 1-6 alkoxy group, or the like; and R 3 represents hydrogen atom, a C 1-6 alkyl group, or the like], or a salt thereof which has a blood LDL cholesterol-reducing action, and is useful as an active ingredient of medicaments.

  通用式（I）所代表的化合物【其中R1代表C1-6烷基基团、卤素原子或类似物；A代表苯基基团或类似物；X代表—CH(R3)—、—O—、—NH—或类似物；Y代表—O—、—NH—、—N═或—S—；……代表单键或双键；n代表1至3；R2代表C1-6烷基基团、C1-6烷氧基基团或类似物；R3代表氢原子、C1-6烷基基团或类似物】，或其盐，具有降低血液LDL胆固醇作用，并且可用作药物的活性成分。
• HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND
  申请人：Iwakoshi Mitsuhiko

  公开号：US20110039843A1

  公开（公告）日：2011-02-17

  Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A 1 and A 2 independently represent a nitrogen atom or the like; R 1 and R 4 independently represent a halogen atom or the like; R 2 and R 3 independently represent a halogen atom or the like; R 5 and R 6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R 5 and R 6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.

  揭示了一种包括如下式（1）所表示的融合杂环化合物作为活性成分的有害节肢动物控制组合物[其中A1和A2独立地表示氮原子或类似物；R1和R4独立地表示卤素原子或类似物；R2和R3独立地表示卤素原子或类似物；R5和R6独立地表示可被取代的直链C1-C6烃基或类似物（前提是R5和R6不能同时表示氢原子）；n表示0或1]。该有害节肢动物控制组合物具有优异的效果，可用于控制有害节肢动物。
• ARTHROPOD PEST CONTROL METHOD AND COMPOSITION
  申请人：IWAKOSHI Mitsuhiko

  公开号：US20120245167A1

  公开（公告）日：2012-09-27

  Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A 1 and A 2 independently represent a nitrogen atom or the like; R 1 and R 4 independently represent a halogen atom or the like; R 2 and R 3 independently represent a halogen atom or the like; R 5 and R 6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R 5 and R 6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.

  公开了一种有害节肢动物控制组合物，其包含作为活性成分的由式（1）表示的融合杂环化合物[其中A1和A2独立地表示氮原子或类似物；R1和R4独立地表示卤素原子或类似物；R2和R3独立地表示卤素原子或类似物；R5和R6独立地表示线性C1-C6烃基，可以被取代，或类似物（前提是R5和R6不能同时表示氢原子）；n表示0或1]。该有害节肢动物控制组合物具有优异的控制有害节肢动物的功效。
• COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
  申请人：Otsuki Junko

  公开号：US20120245159A1

  公开（公告）日：2012-09-27

  The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a neonicotinoid compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a neonicotinoid compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.

  本发明提供了一种节肢动物害虫控制组合物，其包括紧缩杂环化合物和新烟碱类化合物作为活性成分；一种控制节肢动物害虫的方法，其包括将有效量的紧缩杂环化合物和新烟碱类化合物应用于节肢动物害虫或节肢动物害虫栖息地的方法等。