1,4-Dicyclohexyl-piperazin | 19982-04-8

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-Dicyclohexyl-piperazin
• 英文别名: 1,4-Dicyclohexylpiperazine
• CAS: 19982-04-8
• 化学式: C₁₆H₃₀N₂
• 分子量: 250.428
• InChiKey: PMKYZLGUIDMJBM-UHFFFAOYSA-N

物化性质

• 熔点：
  118 °C
• 沸点：
  359.9±10.0 °C(Predicted)
• 密度：
  1.006±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,4-Bis(1-cyclohexenyl)piperazin 在 sodium tetrahydroborate 、 氢气 、 nickel dichloride 作用下， 以 异丙醇 为溶剂， 70.0 ℃ 、101.33 kPa 条件下， 反应 6.0h， 以87%的产率得到1,4-Dicyclohexyl-piperazin
  参考文献：
  名称：

  Colloid and nanosized catalysts in organic synthesis: IX. Hydrogenation of enamines with hydrogen at atmospheric pressure

  摘要：

  Hydrogenation of enamines with hydrogen at atmospheric pressure was performed using nickel nanoparticles as a catalyst. The reaction may be used to produce tertiary amines under mild conditions using an accessible catalyst.

  DOI：

  10.1134/s1070363214110036

文献信息

• METHOD OF PRODUCING CARBONYL COMPOUND AND FLOW TYPE REACTION SYSTEM OF PRODUCING CARBONYL COMPOUND
  申请人：FUJIFILM Corporation

  公开号：US20220135517A1

  公开（公告）日：2022-05-05

  There are provided a method of producing a carbonyl compound by a flow type reaction, including introducing a triphosgene solution, a tertiary amine solution, and an active hydrogen-containing compound solution into flow channels different from each other to cause the respective solutions to flow inside the respective flow channels, joining the respective solutions that flow inside the respective flow channels simultaneously or sequentially so that a reaction between phosgene and an active hydrogen-containing compound occurs, and obtaining a carbonyl compound in a joining solution, in which a non-aqueous organic solvent is used as a solvent of each of the respective solutions and a compound having a cyclic structure is used as the tertiary amine; and a flow type reaction system that is suitable for carrying out this production method.

  提供了一种通过流动反应制备羰基化合物的方法，包括将三噻环氯甲酰氯溶液、三级胺溶液和含活性氢的化合物溶液引入彼此不同的流道中，使各自的溶液在各自的流道内流动，同时或依次加入在各自的流道内流动的各自的溶液，以使氯甲酰氯和含活性氢的化合物之间发生反应，并在联合溶液中获得羰基化合物，在其中使用非水有机溶剂作为各自溶液的溶剂，以及使用具有环状结构的化合物作为三级胺；以及适用于执行该生产方法的流动反应系统。
• METHOD FOR PRODUCING CARBONYL COMPOUND AND FLOW REACTION SYSTEM USED FOR PRODUCTION OF CARBONYL COMPOUND
  申请人：FUJIFILM Corporation

  公开号：EP4019493A1

  公开（公告）日：2022-06-29

  There are provided a method of producing a carbonyl compound by a flow type reaction, including introducing a triphosgene solution into a flow channel (I), bringing the triphosgene solution into contact with a solid catalyst immobilized in at least a part of the flow channel (I) to generate a phosgene solution while the triphosgene solution is flowing through the flow channel (I), joining the phosgene solution and an active hydrogen-containing compound solution that flows inside the flow channel (II), which are subsequently allowed to flow downstream inside a reaction flow channel to be reacted in a presence of a tertiary amine, and obtaining a carbonyl compound in a joining solution; and a flow type reaction system that is suitable for carrying out this production method.

  提供了一种通过流动型反应生产羰基化合物的方法，包括将三光气溶液引入流动通道（I），在三光气溶液流经流动通道（I）时，使三光气溶液与固定在流动通道（I）至少一部分中的固体催化剂接触，生成光气溶液、将光气溶液与流道 (II) 内的活性含氢化合物溶液汇合，然后让它们顺流进入反应流道，在叔胺存在下进行反应，并在汇合溶液中获得羰基化合物；以及适用于该生产方法的流动式反应系统。
• Procatalysts, catalyst systems, and use in olefin polymerization
  申请人：——

  公开号：US20010025005A1

  公开（公告）日：2001-09-27

  There are described solid procatalysts, catalyst systems incorporating the solid procatalysts, and the use of the catalyst systems in olefin polymerization and interpolymerization.

  本文介绍了固体原催化剂、含有固体原催化剂的催化剂体系以及催化剂体系在烯烃聚合和互聚中的应用。
• Procatalysts, catalyst systems, and use in OLEFIN polymerization
  申请人：——

  公开号：US20010029286A1

  公开（公告）日：2001-10-11

  There are described solid procatalysts, catalyst systems incorporating the solid procatalysts, and the use of the catalyst systems in olefin polymerization and interpolymerization.

  本文介绍了固体原催化剂、含有固体原催化剂的催化剂体系以及催化剂体系在烯烃聚合和互聚中的应用。
• Derivatives of Piperazine. XVIII. Synthesis of Substituted Piperazines and the Hydrolysis of Amines
  作者：J. P. Bain、C. B. Pollard

  DOI：10.1021/ja01265a039

  日期：1939.10.1