2-[吗啉-4-基(苯基)甲基]萘-1-醇 | 102474-89-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-[吗啉-4-基(苯基)甲基]萘-1-醇
• 英文名称: 2-[morpholin-4-yl(phenyl)methyl]naphthalen-1-ol
• 英文别名: 2-(α-Morpholino-benzyl)-[1]naphthol
• CAS: 102474-89-5
• 化学式: C₂₁H₂₁NO₂
• 分子量: 319.403
• InChiKey: RBAHJVKVIABDMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吗啉 、 2-bromo-2-(α-bromo-benzyl)-3,4-dihydro-2H-naphthalen-1-one 生成 2-[吗啉-4-基(苯基)甲基]萘-1-醇
  参考文献：
  名称：

  The Chemistry of Derivatives of 2-Benzaltetralone. I. A Novel Rearrangement Leading to 2-Substituted-1-naphthols^*

  摘要：

  DOI：

  10.1021/ja01558a060

文献信息

• Catalyst-Free, One-Pot, Expeditious Synthesis of Aminoalkylnaphthols at Room Temperature
  作者：Chhanda Mukhopadhyay、Sunil Rana、Ray J. Butcher

  DOI：10.1080/00397911.2011.575524

  日期：2012.10.15

  Aminoalkylnaphthols possess several biological and catalytic activities. A methodology has been developed for the multicomponent one-pot synthesis of aminoalkylnaphthols in dichloromethane under catalyst-free conditions at room temperature. The present approach possesses several advantages such as excellent yields, quick reaction time, mild reaction conditions, and very easy purification processes. Thirteen new compounds in addition to six known compounds have been synthesized by this methodology.
• The Chemistry of Derivatives of 2-Benzaltetralone. I. A Novel Rearrangement Leading to 2-Substituted-1-naphthols^*
  作者：Alfred Hassner、Norman H. Cromwell、Stanley J. Davis

  DOI：10.1021/ja01558a060

  日期：1957.1