(+/-)-3-(6-bromo-pyridazin-3-yloxy)-1-aza-bicyclo[2.2.2]octane | 663191-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: (+/-)-3-(6-bromo-pyridazin-3-yloxy)-1-aza-bicyclo[2.2.2]octane
• 英文别名: 3-(6-Bromopyridazin-3-yl)oxy-1-azabicyclo[2.2.2]octane
• CAS: 663191-73-9
• 化学式: C₁₁H₁₄BrN₃O
• 分子量: 284.156
• InChiKey: UYDJFXWILYZAEM-UHFFFAOYSA-N

物化性质

• 沸点：
  425.9±35.0 °C(Predicted)
• 密度：
  1.57±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (+/-)-3-(6-bromo-pyridazin-3-yloxy)-1-aza-bicyclo[2.2.2]octane 、 苯乙炔 在 copper(l) iodide N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 15.0h， 以19%的产率得到(+/-)-3-(6-phenylethynyl-pyridazin-3-yloxy)-1-aza-bicyclo[2.2.2]octane
  参考文献：
  名称：

  [EN] NOVEL AZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE
  [FR] NOUVEAUX DERIVES ARYLES AZABICYCLIQUES ET LEUR UTILISATION MEDICALE

  摘要：

  该发明涉及一种新型的式(I)的氮杂双环芳基衍生物，发现它们是乙酰胆碱受体的胆碱能配体，同时也是单胺受体和转运体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩、内分泌疾病、神经退行性疾病、炎症、疼痛以及由化学物质滥用终止引起的戒断症状等多种疾病或障碍具有用处。

  公开号：

  WO2006040352A1
• 作为产物：
  描述：

  3,6-二溴哒嗪 、 奎宁环-3-醇 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以30%的产率得到(+/-)-3-(6-bromo-pyridazin-3-yloxy)-1-aza-bicyclo[2.2.2]octane
  参考文献：
  名称：

  [EN] NOVEL AZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE
  [FR] NOUVEAUX DERIVES ARYLES AZABICYCLIQUES ET LEUR UTILISATION MEDICALE

  摘要：

  该发明涉及一种新型的式(I)的氮杂双环芳基衍生物，发现它们是乙酰胆碱受体的胆碱能配体，同时也是单胺受体和转运体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩、内分泌疾病、神经退行性疾病、炎症、疼痛以及由化学物质滥用终止引起的戒断症状等多种疾病或障碍具有用处。

  公开号：

  WO2006040352A1

文献信息

• [EN] NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE<br/>[FR] NOUVEAUX DERIVES QUINUCLIDINIQUES ET LEUR UTILISATION
  申请人：NEUROSEARCH AS

  公开号：WO2004016608A1

  公开（公告）日：2004-02-26

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  该发明涉及新型喹诺啉衍生物及其作为药物的用途。由于其药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱系统、外周神经系统（PNS）、平滑肌收缩、内分泌疾病、神经退行性疾病、炎症、疼痛以及由于滥用化学物质终止而引起的戒断症状等疾病或疾病有用。
• Novel quinuclidine derivatives and their use
  申请人：Peters Dan

  公开号：US20050245567A1

  公开（公告）日：2005-11-03

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的莨菪碱衍生物及其作为药物的使用。由于它们的药理特性，本发明中的化合物可能对治疗与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统有关的疾病或疾患、与平滑肌收缩有关的疾病或疾患、内分泌疾病或疾患、神经退行性疾病或疾患、与炎症、疼痛有关的疾病或疾患以及因化学物质滥用终止而引起的戒断症状可能有用。
• NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE
  申请人：PETERS Dan

  公开号：US20090005390A1

  公开（公告）日：2009-01-01

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的蒽环啶衍生物及其作为药物的用途。由于它们的药理特性，本发明中的化合物可能对多种与中枢神经系统（CNS）、外周神经系统（PNS）、平滑肌收缩有关的疾病或紊乱，内分泌疾病或紊乱，神经退行性疾病或紊乱，炎症、疼痛以及由于滥用化学物质而导致的戒断症状等疾病或紊乱有用。
• Novel Azabicyclic Aryl Derivatives and Their Medical Use
  申请人：Peters Dan

  公开号：US20070299082A1

  公开（公告）日：2007-12-27

  This invention relates to novel azabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及一种新型的氮杂双环芳基衍生物，发现它们是乙酰胆碱受体的胆碱能配体，并且是单胺类受体和转运体的调节剂。由于它们的药理特性，该发明的化合物可用于治疗与中枢神经系统（CNS）、外周神经系统（PNS）、平滑肌收缩相关的疾病或障碍、内分泌疾病或障碍、神经退行性疾病或障碍、炎症、疼痛以及化学物质滥用终止引起的戒断症状等多种疾病或障碍相关的疾病或障碍的治疗。
• Quinuclidine derivatives and their use
  申请人：NEUROSEARCH A/S

  公开号：EP1905771A2

  公开（公告）日：2008-04-02

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型奎宁环衍生物及其药物用途。由于其药理特性，本发明的化合物可用于治疗各种疾病或失调，如与中枢神经系统（CNS）胆碱能系统、周围神经系统（PNS）、平滑肌收缩相关的疾病或失调、内分泌疾病或失调、神经变性相关的疾病或失调、炎症相关的疾病或失调、疼痛以及终止滥用化学物质引起的戒断症状。