2-乙基-1H-萘并[2,3-d]咪唑 | 97508-57-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-乙基-1H-萘并[2,3-d]咪唑
• 英文名称: 2-ethyl-1H-naphth[2,3-d]imidazole
• 英文别名: 2-Aethyl-1H-naphth[2,3-d]imidazol；2-Ethyl-1H-naphtho[2,3-D]imidazole；2-ethyl-1H-benzo[f]benzimidazole
• CAS: 97508-57-1
• 化学式: C₁₃H₁₂N₂
• mdl: MFCD09259136
• 分子量: 196.252
• InChiKey: BAWAHZPNWYHRPE-UHFFFAOYSA-N

物化性质

• 熔点：
  250 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  445.5±14.0 °C(Predicted)
• 密度：
  1.211±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  2,3-二氨基萘 、 丙酸 生成 2-乙基-1H-萘并[2,3-d]咪唑
  参考文献：
  名称：

  401.一些2-取代的线性萘并咪唑

  摘要：

  DOI：

  10.1039/jr9580001974

文献信息

• Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor
  申请人：Kindrachuk David E.

  公开号：US20090156613A1

  公开（公告）日：2009-06-18

  Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H 4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

  描述了具有双环杂环芳基取代的咪唑化合物，这些化合物可用作H4受体调节剂。这种化合物可以用于制备药物组合物，用于调节组脊髓H4受体活性以及治疗由H4受体活性介导的疾病状态、紊乱和症状，例如过敏、哮喘、自身免疫疾病和瘙痒症。
• AMINO-BENZAZOLES AS P2Y1 RECEPTOR INHIBITORS WITH PYRIDINE RING AND HETEROCYCLIC COMPONENTS
  申请人：Herpin Timothy F.

  公开号：US20080275090A1

  公开（公告）日：2008-11-06

  The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y 1 receptor activity.

  本发明提供了新型的氨基苯并咪唑及其类似物，它们是选择性抑制人类P2Y1受体的抑制剂。本发明还提供了各种药物组合物和方法，用于治疗对P2Y1受体活性调节敏感的疾病。
• Microwave-assisted one step high-throughput synthesis of benzimidazoles
  作者：Shou-Yuan Lin、Yuko Isome、Ethan Stewart、Ji-Feng Liu、Daniel Yohannes、Libing Yu

  DOI：10.1016/j.tetlet.2006.02.127

  日期：2006.4

  One-pot synthesis of benzimidazoles from diamines and carboxylic acids was developed under microwave irradiation condition, which provided a practical and efficient method for high-throughput synthesis of this important class of heterocyclic compounds. (c) 2006 Elsevier Ltd. All rights reserved.
• Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections
  申请人：Hedstrom Lizbeth K.

  公开号：US20100022547A1

  公开（公告）日：2010-01-28

  One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of C. parvum inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
• US7470712B2
  申请人：——

  公开号：US7470712B2

  公开（公告）日：2008-12-30