4-{(1S,2R,4S)-1,2,3,4-tetrahydro-1,4-epoxynaphthalen-2-yl}morpholine | 1567316-82-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4-{(1S,2R,4S)-1,2,3,4-tetrahydro-1,4-epoxynaphthalen-2-yl}morpholine
• 英文别名: 4-[(1S,8S,9R)-11-oxatricyclo[6.2.1.02,7]undeca-2,4,6-trien-9-yl]morpholine
• CAS: 1567316-82-8
• 化学式: C₁₄H₁₇NO₂
• 分子量: 231.294
• InChiKey: ZXTFHVUNQPDEJK-RDBSUJKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  环己-1,3-二烯-5-炔 在 1,2-bis(bis(3,5-bis(trifluoromethyl)phenyl)phosphanyl)benzene 、 copper(l) chloride 、 lithium tert-butoxide 作用下， 以 甲醚 为溶剂， 反应 48.0h， 生成 4-{(1S,2R,4S)-1,2,3,4-tetrahydro-1,4-epoxynaphthalen-2-yl}morpholine
  参考文献：
  名称：

  Copper-Catalyzed Enantioselective Formal Hydroamination of Oxa- and Azabicyclic Alkenes with Hydrosilanes and Hydroxylamines

  摘要：

  A CuCl/(R,R)-Ph-BPE-catalyzed enantioselective formal hydroamination of oxa- and azabicyclic alkenes with polymethylhydrosiloxane (PMHS) and O-benzoylhydroxylamines has been developed. The efficient and stereoselective net addition of hydrogen and nitrogen atoms provides the corresponding optically active oxa- and azanorbornenyl- and -norbomanylamines in good yields and good enantiomeric ratios.

  DOI：

  10.1021/ol5003219

文献信息

• Copper-Catalyzed Enantioselective Formal Hydroamination of Oxa- and Azabicyclic Alkenes with Hydrosilanes and Hydroxylamines
  作者：Yuya Miki、Koji Hirano、Tetsuya Satoh、Masahiro Miura

  DOI：10.1021/ol5003219

  日期：2014.3.7

  A CuCl/(R,R)-Ph-BPE-catalyzed enantioselective formal hydroamination of oxa- and azabicyclic alkenes with polymethylhydrosiloxane (PMHS) and O-benzoylhydroxylamines has been developed. The efficient and stereoselective net addition of hydrogen and nitrogen atoms provides the corresponding optically active oxa- and azanorbornenyl- and -norbomanylamines in good yields and good enantiomeric ratios.