1-methyl-4[(benzofuran-2-yl) (phenyl)methyl]piperazine | 82158-04-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 1-methyl-4[(benzofuran-2-yl) (phenyl)methyl]piperazine
• 英文别名: 1-Methyl-4[(benzofuran-2-yl)(phenyl)methyl]piperazine；1-[1-benzofuran-2-yl(phenyl)methyl]-4-methylpiperazine
• CAS: 82158-04-1
• 化学式: C₂₀H₂₂N₂O
• 分子量: 306.407
• InChiKey: LWQVYRAYJOCEDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  19.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯甲醛 、 N-乙基苯胺 生成 1-methyl-4[(benzofuran-2-yl) (phenyl)methyl]piperazine
  参考文献：
  名称：

  KULIEV, A. B.;DZHAVADOV, M. M.;KULIEV, F. A.;ABDULLAEV, B. I., XIMIYA I TEXNOL. TOPLIV I MASEL, 1982, N 10, 18-19

  摘要：

  DOI：

文献信息

• N-[(Benzofuran-2-yl)(phenyl)methyl]-alkylene diamines useful in treating
  申请人：A. Menarini S.A.S.

  公开号：US04485112A1

  公开（公告）日：1984-11-27

  A 2-substituted benzofuran derivative of general formula I or II ##STR1## in which R.sub.1 and R.sub.2, can be the same or different, and are a hydrogen atom, a halogen atom, an alkyl group containing 1 to 4 carbon atoms, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH.sub.2, NH-alkyl, N(alkyl).sub.2, NH(CO-alkyl), NH(CO-aryl) or NO.sub.2 group, or R.sub.1 and R.sub.2 can together form a ring of 5-8 carbon atoms; R.sub.3 is a hydrogen atom, an alkyl group containing 1 to 4 carbon atoms or an aryl group; R.sub.4 is a hydrogen atom, an alkyl group, an aryl or an arylalkyl group, R.sub.5 is a hydroxyl group, an alkoxy group, an OCO-aryl an OCO-alkyl, OCONH-alkyl or OCONH-aryl group, ##STR2## where n is a number between 1 and 4, R.sub.7 is a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, and R.sub.8 and R.sub.9, which can be the same or different, represent a hydrogen atom, an alkyl group, an aryl group, an alkoyl group, arylalkoyl group or an aroyl group, or can together form a heterocyclic ring which can contain supplementary heteratoms, and R.sub.6 is a hydrogen or halogen atom, an alkyl group, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH.sub.2, NH-alkyl, N(alkyl).sub.2, NHCO-alkyl, NHCO-aryl or NO.sub.2 group. The compounds are useful for treating arrhythmic, histaminic and tussive conditions.

  一种通式I或II的2-取代苯并呋喃衍生物，其中R.sub.1和R.sub.2可以相同或不同，是氢原子、卤素原子、含1到4个碳原子的烷基、芳基烷基、芳基、羟基、烷氧基、或NH.sub.2、NH-烷基、N(烷基).sub.2、NH(CO-烷基)、NH(CO-芳基)或NO.sub.2基团，或R.sub.1和R.sub.2可以共同形成一个含有5-8个碳原子的环；R.sub.3是氢原子、含1到4个碳原子的烷基或芳基；R.sub.4是氢原子、烷基、芳基或芳基烷基；R.sub.5是羟基、烷氧基、OCO-芳基、OCO-烷基、OCONH-烷基或OCONH-芳基基团，其中n是1到4之间的数字，R.sub.7是氢原子或含1到4个碳原子的烷基，而R.sub.8和R.sub.9可以相同或不同，代表氢原子、烷基、芳基、酰基、芳基酰基或可以共同形成含有补充杂原子的杂环，而R.sub.6是氢或卤素原子、烷基、芳基烷基、芳基、羟基、烷氧基或NH.sub.2、NH-烷基、N(烷基).sub.2、NHCO-烷基、NHCO-芳基或NO.sub.2基团。这些化合物可用于治疗心律失常、组胺和咳嗽等疾病。
• 2-substituted benzofuran derivatives useful in treating cardiac
  申请人：A. Menarini S.A.S.

  公开号：US04604392A1

  公开（公告）日：1986-08-05

  A 2-substituted benzofuran derivative of general formula I or II ##STR1## in which R.sub.1 and R.sub.2, can be the same or different, and are a hydrogen atom, a halogen atom, an alkyl group containing 1 to 4 carbon atoms, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH.sub.2, NH-alkyl, N(alkyl).sub.2, NH(CO-alkyl), NH(CO-aryl) or NO.sub.2 group, or R.sub.1 and R.sub.2 can together form a ring of 5-8 carbon atoms; R.sub.3 is a hydrogen atom, an alkyl group containing 1 to 4 carbon atoms or an aryl group; R.sub.4 is a hydrogen atom, an alkyl group, an aryl or an arylalkyl group, R.sub.5 is a hydroxyl group, an alkoxy group, an OCO-alkyl, an OCO-aryl, OCOHN-alkyl or OCONH-aryl group, ##STR2## where n is a number between 1 and 4, R.sub.7 is a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, and R.sub.8 and R.sub.9, which can be the same or different, represent a hydrogen atom, an alkyl group, an aryl group, an alkoyl group, arylalkoyl group or an aroyl group, or can together form a heterocyclic ring which can contain supplementary heteratoms, and R.sub.6 is a hydrogen or halogen atom, an alkyl group, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH.sub.2, NH-alkyl, (N(alkyl).sub.2, NHCO-alkyl, NHCO-aryl or NO.sub.2 group. The compounds are useful for treating cardiac arrhythmic, histaminic and tussive conditions.

  通式I或II的2-取代苯并呋喃衍生物，其中R1和R2可以相同也可以不同，是氢原子、卤素原子、含有1至4个碳原子的烷基、芳基烷基、芳基、羟基、烷氧基、或NH2、NH-烷基、N(烷基)2、NH(CO-烷基)、NH(CO-芳基)或NO2基，或R1和R2可以一起形成一个5-8个碳原子的环；R3是氢原子、含有1至4个碳原子的烷基或芳基；R4是氢原子、烷基、芳基或芳基烷基；R5是羟基、烷氧基、OCO-烷基、OCO-芳基、OCOHN-烷基或OCONH-芳基基团，其中n是1至4之间的数字，R7是氢原子或含有1至4个碳原子的烷基，R8和R9可以相同也可以不同，表示氢原子、烷基、芳基、酰基、芳基酰基或者可以一起形成一个含有补充杂原子的杂环，R6是氢或卤素原子、烷基、芳基烷基、芳基、羟基、烷氧基或NH2、NH-烷基、N(烷基)2、NHCO-烷基、NHCO-芳基或NO2基。这些化合物可用于治疗心律失常、组胺和咳嗽疾病。
• PESTELLINI, V.;GHELARDONI, M.;MAGGI, C. A.;RONCUCCI, G.;MELI, A.
  作者：PESTELLINI, V.、GHELARDONI, M.、MAGGI, C. A.、RONCUCCI, G.、MELI, A.

  DOI：——

  日期：——
• US4485112A
  申请人：——

  公开号：US4485112A

  公开（公告）日：1984-11-27
• US4604392A
  申请人：——

  公开号：US4604392A

  公开（公告）日：1986-08-05