3-[(Butan-2-yl)amino]propan-1-ol | 137788-49-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-[(Butan-2-yl)amino]propan-1-ol
• 英文别名: 3-(butan-2-ylamino)propan-1-ol
• CAS: 137788-49-9
• 化学式: C₇H₁₇NO
• mdl: MFCD11163060
• 分子量: 131.22
• InChiKey: VMPRBERBKMHSKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  sec-Butyl-(3-hydroxy-propyl)-carbamic acid tert-butyl ester 以98%的产率得到
  参考文献：
  名称：

  Kabalka George W., Li Nan-Sheng, Pace R. David, Synth. Commun, 25 (1995) N 14, S 2135-2143

  摘要：

  DOI：

文献信息

• [EN] PYRIDAZIN-3 (2H) -ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS<br/>[FR] DERIVES DE PYRIDAZINE-3(2H)-ONES ET UTILISATION EN TANT QU'INHIBITEURS DE PDE4
  申请人：ALMIRALL PRODESFARMA SA

  公开号：WO2005049581A1

  公开（公告）日：2005-06-02

  New pyridazin-e-(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of phosphodiesterase 4.

  新吡啶唑-e-(2H)-酮衍生物，具有通用公式(I)的化学结构被公开；以及它们的制备过程，包含它们的药物组合物以及它们作为磷酸二酯酶4抑制剂的疗法使用。
• [EN] 4-AMINOTHIENO[2,3-d]PYRIMIDINE-6-CARBONITRILE DERIVATIVES AS PDE7 INHIBITORS<br/>[FR] DERIVES DE 4-AMINOTHIENO[2,3-D]PYRIMIDINE-6-CARBONITRILE UTILISES COMME INHIBITEURS DE PDE7
  申请人：ALMIRALL PRODESFARMA SA

  公开号：WO2004065391A1

  公开（公告）日：2004-08-05

  New 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives having the chemical structure of general formula (I), and pharmaceutically acceptable salts thereof are disclosed as well as processes for their preparation and to pharmaceutical compositions containing them and their use in the treatment, prevention or suppression of pathological conditions, diseases and disorders susceptible of being improved by inhibition of PDE7.

  揭示了具有通用式(I)的化学结构的新4-氨基噻吩[2,3-d]嘧啶-6-碳腈衍生物，以及其药学上可接受的盐，以及它们的制备过程、含有它们的药物组合物以及它们在治疗、预防或抑制通过抑制PDE7可改善的病理状况、疾病和疾病的用途。
• [EN] PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS<br/>[FR] NOUVEAUX DERIVES DE PYRIDAZIN-3(2H)-ONE ET LEURS UTILISATION EN TANT QU'INHIBITEURS DE PDE4
  申请人：ALMIRALL PRODESFARMA SA

  公开号：WO2005123693A1

  公开（公告）日：2005-12-29

  The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives, to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and are thus useful in the treatment, prevention and suppression of related pathological conditions, diseases and disorders, in particular asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, topic dermatitis, psoriasis or irritable bowel disease.

  该发明涉及新的治疗上有用的吡啶并嗪-3(2H)-酮衍生物，以及它们的制备方法和含有它们的药物组合物。这些化合物是磷酸二酯酶4（PDE4）的有效和选择性抑制剂，因此在治疗、预防和抑制相关病理条件、疾病和障碍方面具有用途，特别是哮喘、慢性阻塞性肺病、类风湿性关节炎、局部性皮炎、牛皮癣或肠易激综合征。
• [EN] NEW TRICYCLIC DERIVATIVES AS LTD4 ANTAGONISTS<br/>[FR] NOUVEAUX DERIVES TRICYCLIQUES EN TANT QU'ANTAGONISTES DE LTD4
  申请人：ALMIRALL PRODESFARMA SA

  公开号：WO2004043966A1

  公开（公告）日：2004-05-27

  Compounds of formula (I) and their pharmaceutically acceptable salts are provided as well as processes for the manufacture of such compounds. The compounds are useful in the treatment or prevention of inflammatory and allergic diseases.

  提供了化学式（I）的化合物及其药用可接受的盐，以及制备这些化合物的方法。这些化合物在治疗或预防炎症和过敏性疾病方面是有用的。
• [EN] PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS<br/>[FR] DERIVES DE PYRIDAZIN-3(2H)-ONE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA PDE4
  申请人：ALMIRALL PRODESFARMA SA

  公开号：WO2005123692A1

  公开（公告）日：2005-12-29

  The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives of Formula (I) and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and are thus useful in the treatment, prevention or suppression of pathological conditions, diseases and disorders known to be susceptible of being improved by inhibition of PDE4 such as asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis or irritable bowel disease.

  该发明涉及公式（I）的新治疗上有用的吡啶嗪-3(2H)-酮衍生物，以及含有它们的药物组合物。这些化合物是磷酸二酯酶4（PDE4）的有效和选择性抑制剂，因此在治疗、预防或抑制病理状况、已知可通过PDE4抑制改善的疾病和疾病，如哮喘、慢性阻塞性肺病、类风湿性关节炎、特应性皮炎、牛皮癣或肠易激综合症方面是有用的。