3-benzyl-2-methyl-3-azabicyclo[3.1.0]hexane | 659736-81-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-benzyl-2-methyl-3-azabicyclo[3.1.0]hexane
• CAS: 659736-81-9
• 化学式: C₁₃H₁₇N
• 分子量: 187.285
• InChiKey: AMCUMGKYDRVPRE-UHFFFAOYSA-N

物化性质

• 沸点：
  255.1±9.0 °C(Predicted)
• 密度：
  1.059±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-benzyl-2-methyl-3-azabicyclo[3.1.0]hexane 在 palladium on activated charcoal 氢气 作用下， 生成 2-甲基-3-氮杂双环[3.1.0]己烷
  参考文献：
  名称：

  Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine

  摘要：

  Novel derivatives of Tolterodine (1) and Oxybutynin (2) have been designed using conformationally restricted azabicyclics as replacement for open-chain amines. The synthesis and structure-activity relationships are presented. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.036
• 作为产物：
  描述：

  cis-1,2-cyclopropanedicarboxylic acid 在 lithium aluminium tetrahydride 、 氯化亚砜 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 3-benzyl-2-methyl-3-azabicyclo[3.1.0]hexane
  参考文献：
  名称：

  Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine

  摘要：

  Novel derivatives of Tolterodine (1) and Oxybutynin (2) have been designed using conformationally restricted azabicyclics as replacement for open-chain amines. The synthesis and structure-activity relationships are presented. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.036

文献信息

• [EN] 3,6-DISUBSTITUTED AZABICYCLO [3.1.0]HEXANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS<br/>[FR] DERIVES 3,6-DISUBSTITUES D'AZABICYCLO [3.1.0]HEXANE UTILISES COMME ANTAGONISTES DES RECEPTEURS MUSCARINIQUES
  申请人：RANBAXY LAB LTD

  公开号：WO2004014853A1

  公开（公告）日：2004-02-19

  This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

  这项发明通常涉及3,6-二取代的氮杂双环[3.1.0]己烷衍生物。本发明的化合物是肌碱受体拮抗剂，可用于治疗通过肌碱受体介导的呼吸系统、泌尿系统和消化系统的各种疾病。该发明还涉及一种制备本发明化合物的方法，含有本发明化合物的药物组合物以及治疗通过肌碱受体介导的疾病的方法。
• [EN] 3,6-DISUBSTITUTED AZABICYCLO [3.1.0] HEXANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONIST<br/>[FR] DERIVES D'AZABICYCLO[3.1.0] HEXANE 3,6-DISUBSTITUES, UTILES EN TANT QU'AGONISTES DE RECEPTEURS MUSCARINIQUES
  申请人：RANBAXY LAB LTD

  公开号：WO2004014363A1

  公开（公告）日：2004-02-19

  This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0] hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors.The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

  本发明通常涉及3,6-二取代的氮杂双环[3.1.0]己烷衍生物。本发明的化合物是肌肉型乙酰胆碱受体拮抗剂，可用于治疗通过肌肉型乙酰胆碱受体介导的呼吸、泌尿和胃肠系统的各种疾病。本发明还涉及制备本发明化合物的方法、含有本发明化合物的制药组合物以及治疗通过肌肉型乙酰胆碱受体介导的疾病的方法。
• [EN] AZABICYCLO QUINOLONE CARBOXYLIC ACIDS
  申请人：PFIZER INC.

  公开号：WO1991002526A1

  公开（公告）日：1991-03-07

  (EN) Quinolone carboxylic acids 7-substituted by azabicyclo groups have antibacterial activity.(FR) Des acides quinolones carboxyliques substitués en 7 par des groupes azabicyclo ont une activité antibactérienne.

  (EN) Quinolone carboxylic acids 7-substituted by azabicyclo groups have antibacterial activity. 翻译成中文：由azabicyclo基团7-取代的喹诺酮羧酸具有抗菌活性。 (FR) Des acides quinolones carboxyliques substitués en 7 par des groupes azabicyclo ont une activité antibactérienne. 翻译成中文：由azabicyclo基团在7位取代的喹诺酮羧酸具有抗菌活性。
• 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
  申请人：Mehta Anita

  公开号：US20060122253A1

  公开（公告）日：2006-06-08

  This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

  本发明一般涉及3,6-二取代的氮杂双环[3.1.0]己烷衍生物。本发明的化合物是肌肉型乙酰胆碱受体拮抗剂，可用于治疗通过肌肉型乙酰胆碱受体介导的呼吸、泌尿和胃肠系统的各种疾病。本发明还涉及一种制备本发明化合物的方法，含有本发明化合物的制药组合物以及治疗通过肌肉型乙酰胆碱受体介导的疾病的方法。
• 3,6-Disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor
  申请人：Mehta Anita

  公开号：US20060142371A1

  公开（公告）日：2006-06-29

  This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

  本发明通常涉及3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。本发明的化合物是肌肉型乙酰胆碱受体拮抗剂，可用于治疗通过肌肉型乙酰胆碱受体介导的呼吸系统、泌尿系统和胃肠系统的各种疾病。本发明还涉及一种制备本发明化合物的方法，含有本发明化合物的制药组合物以及治疗通过肌肉型乙酰胆碱受体介导的疾病的方法。