9-[2-[(1S)-1-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]-1,3-dioxolan-4-yl]nonanoic acid | 340156-86-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9-[2-[(1S)-1-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]-1,3-dioxolan-4-yl]nonanoic acid
• CAS: 340156-86-7
• 化学式: C₂₉H₃₇NO₆
• 分子量: 495.616
• InChiKey: FUFPNAXEFXOVOP-ODXIDCHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  36
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  94.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Fmoc-L-缬氨酸 、 Fmoc-L-异亮氨酸 、 9-[2-[(1S)-1-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]-1,3-dioxolan-4-yl]nonanoic acid 生成 Fmoc-Ile-Val-Ala-H
  参考文献：
  名称：

  Solid-phase synthesis of peptide aldehydes directly on acetal resin

  摘要：

  A practical strategy for solid-phase synthesis of peptide aldehydes has been developed employing a 10,11-dihydroxy-undecanoic acid (DHUA) functionalized resin. High loading levels are obtained for amino aldehydes as their respective acetals. After classical Fmoc SPPS, treatment of the derivatized resin with 95% TFA/H2O affords peptide aldehydes in high yield and purity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00230-1
• 作为产物：
  描述：

  10,11-二羟基十一烷酸 在 三氟甲磺酸三甲基硅酯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 9-[2-[(1S)-1-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]-1,3-dioxolan-4-yl]nonanoic acid
  参考文献：
  名称：

  Solid-phase synthesis of peptide aldehydes directly on acetal resin

  摘要：

  A practical strategy for solid-phase synthesis of peptide aldehydes has been developed employing a 10,11-dihydroxy-undecanoic acid (DHUA) functionalized resin. High loading levels are obtained for amino aldehydes as their respective acetals. After classical Fmoc SPPS, treatment of the derivatized resin with 95% TFA/H2O affords peptide aldehydes in high yield and purity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00230-1