1,5-Bis(dimethoxyphosphoryl)pentane-1,5-dione | 90728-03-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 1,5-Bis(dimethoxyphosphoryl)pentane-1,5-dione
• CAS: 90728-03-3
• 化学式: C₉H₁₈O₈P₂
• 分子量: 316.185
• InChiKey: SINGGJDWRASIQM-UHFFFAOYSA-N

物化性质

• 沸点：
  380.3±52.0 °C(Predicted)
• 密度：
  1.290±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,5-Bis(dimethoxyphosphoryl)pentane-1,5-dione 在 磺酰氯 、 双氧水 、 碳酸氢钠 作用下， 以 乙醚 为溶剂， 反应 30.0h， 生成 α,α'-Dichlorglutarsaeure
  参考文献：
  名称：

  Use of acylphosphonates for the synthesis of α-chlorinated carboxylic and α,α′-dichloro dicarboxylic acids and their derivatives

  摘要：

  alpha -Chloro acylphosphonates and alpha,alpha'-dichloro bisacylphosphonates were prepared in situ by chlorination of acylphosphonates and bisacylphosphonates, respectively, using sulfuryl chloride. Subsequently, they were cleaved to the corresponding alpha -chlorinated or alpha,alpha'-dichlorinated (di)carboxylic acids with a hydrogen peroxide-sodium bicarbonate system. Performing the cleavage with an alcohol or an amine yielded the corresponding alpha -chlorinated esters and alpha -chlorinated amides, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00407-0
• 作为产物：
  描述：

  戊二酰基二氯 、 三甲氧基磷 反应 2.0h， 以90%的产率得到1,5-Bis(dimethoxyphosphoryl)pentane-1,5-dione
  参考文献：
  名称：

  Kanaan, Marwan; Burgada, Ramon, Phosphorus and Sulfur and the Related Elements, 1988, vol. 37, p. 217 - 230

  摘要：

  DOI：

文献信息

• Kanaan, Marwan; Burgada, Ramon, Phosphorus and Sulfur and the Related Elements, 1988, vol. 37, p. 217 - 230
  作者：Kanaan, Marwan、Burgada, Ramon

  DOI：——

  日期：——
• US5338731A
  申请人：——

  公开号：US5338731A

  公开（公告）日：1994-08-16
• Use of acylphosphonates for the synthesis of α-chlorinated carboxylic and α,α′-dichloro dicarboxylic acids and their derivatives
  作者：Christian V Stevens、Bart Vanderhoydonck

  DOI：10.1016/s0040-4020(01)00407-0

  日期：2001.5

  alpha -Chloro acylphosphonates and alpha,alpha'-dichloro bisacylphosphonates were prepared in situ by chlorination of acylphosphonates and bisacylphosphonates, respectively, using sulfuryl chloride. Subsequently, they were cleaved to the corresponding alpha -chlorinated or alpha,alpha'-dichlorinated (di)carboxylic acids with a hydrogen peroxide-sodium bicarbonate system. Performing the cleavage with an alcohol or an amine yielded the corresponding alpha -chlorinated esters and alpha -chlorinated amides, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.