2-亚甲基-3-奎宁酮盐酸盐水合物 | 207556-03-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 中文名称: 2-亚甲基-3-奎宁酮盐酸盐水合物
• 英文名称: 3-Methylene-4-azabicyclo[2.2.2]octan-2-one, chloride, hydrate
• 英文别名: 2-methylidene-1-azabicyclo[2.2.2]octan-3-one;hydrate;hydrochloride
• CAS: 207556-03-4
• 化学式: C8H14ClNO2
• 分子量: 191.65
• InChiKey: LQTODMPQFWEUFY-UHFFFAOYSA-N

物化性质

• 熔点：
  263 °C (dec.)(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  0.39
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-亚甲基-3-奎宁酮盐酸盐水合物 、 potassium carbonate 、 在 二氧化铂 氢气 、 白碳黑 、 氯仿 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以to give 4.7 g (58% yield) of 2-methyl-1-azabicyclo[2.2.2]octan-3-one Compound 8A as a yellow oil的产率得到2-methylquinuclidin-3-one
  参考文献：
  名称：

  Substituted aminoquinuclidine compounds

  摘要：

  本发明涉及取代的氨基喹诺啡类化合物，其作为δ-阿片受体调节剂有用，δ-阿片受体激动剂有用作镇痛剂，δ-阿片受体拮抗剂有用作免疫抑制剂、抗炎剂、用于治疗神经和精神疾病的药物、用于药物和酒精滥用的药物、用于治疗胃炎和腹泻的药物、心血管药物和用于治疗呼吸道疾病的药物。

  公开号：

  US20040110789A1

文献信息

• SUBSTITUTED AMINOQUINUCLIDINE COMPOUNDS AND THEIR USE AS DELTA-OPIOID RECEPTOR LIGANDS
  申请人：Janssen Pharmaceutica NV

  公开号：EP1558610B1

  公开（公告）日：2008-02-27
• US7179818B2
  申请人：——

  公开号：US7179818B2

  公开（公告）日：2007-02-20
• [EN] MUTILIN 14-ESTER DERIVATIVES HAVING ANTIBACTERIAL ACTIVITY<br/>[FR] DERIVES DE 14-ESTER MUTILIN A ACTIVITE ANTIBACTERIENNE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2000037074A1

  公开（公告）日：2000-06-29

  A compound of formula (IA) or (IB) in which R1 is an optionally substituted heteroaryl group which comprises a five membered heteroaromatic ring which has at least one nitrogen atom and which is linked via a nitrogen atom; R2 is vinyl or ethyl; R3 is H, OH or F, and R4 is H, or R3 is H and R4.
• [EN] SUBSTITUTED AMINOQUINUCLIDINE COMPOUNDS AND THEIR USE AS DELTA-OPIOID RECEPTOR LIGANDS<br/>[FR] COMPOSES D'AMINOQUINUCLIDINE DE SUBSTITUTION
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2004035574A2

  公开（公告）日：2004-04-29

  This invention is directed towards substituted aminoquinuclidine compounds of Formula (I); (I) wherein: Ar is selected from the group consisting of aryl and heteroaryl; n is an integer from 0 to 2; useful as delta-opioid receptor modulators, delta-opioid receptor agonists useful as analgesics and delta-opioid receptor antagonists useful as immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.
• Substituted aminoquinuclidine compounds
  申请人：——

  公开号：US20040110789A1

  公开（公告）日：2004-06-10

  This invention is directed towards substituted aminoquinuclidine compounds useful as delta-opioid receptor modulators, delta-opioid receptor agonists useful as analgesics and delta-opioid receptor antagonists useful as immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.

  本发明涉及取代的氨基喹诺啡类化合物，其作为δ-阿片受体调节剂有用，δ-阿片受体激动剂有用作镇痛剂，δ-阿片受体拮抗剂有用作免疫抑制剂、抗炎剂、用于治疗神经和精神疾病的药物、用于药物和酒精滥用的药物、用于治疗胃炎和腹泻的药物、心血管药物和用于治疗呼吸道疾病的药物。