1-hydroxyimino-heptan-2-one | 50627-10-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-hydroxyimino-heptan-2-one
• 英文别名: 1-Oximino-heptanon-(2)；1-Hydroxyimino-heptan-2-on；(1E)-1-hydroxyiminoheptan-2-one
• CAS: 50627-10-6
• 化学式: C₇H₁₃NO₂
• 分子量: 143.186
• InChiKey: BMCZRKHSJOIEHE-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-hydroxyimino-heptan-2-one 在 ammonium hydroxide 、 镍 、 锌 作用下， 生成 1-aminoheptan-2-ol
  参考文献：
  名称：

  Freon; Ser, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1946, vol. 222, p. 447

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 、 sodium nitrite 作用下， 生成 2-庚酮 、 1-hydroxyimino-heptan-2-one
  参考文献：
  名称：

  Clinico-Mycological Profile of Tinea Capitis in North India and Response to Griseofulvin

  摘要：

  AbstractThere is a paucity of literature on tinea capitis from North India. The response to griseofulvin has not been studied as well. We studied 153 consecutive patients of tinea capitis for clinical patterns, causative dermatophytic species, clinico‐etiological correlation, and response to griseofulvin. Culture and sensitivity were done on all patients. All patients were treated with griseofulvin for 6‐8 weeks; non‐responders were further treated with fluconazole. Ninety percent of the patients were less than 15 years of age, 75% belonged to poor socioeconomic groups and 19% had a family history of tinea capitis. The seborrheic variant was the commonest clinical pattern seen in 47.8% of patients, followed by grey patch, black dot, kerion, and alopecia‐areata‐like tinea capitis in 35.9%, 8.5%, 6.5% and 1.3% of patients, respectively. Only 66% of patients had a positive culture. T. violaceum was the commonest dermatophytic species isolated in 38% patients. M. audouinii, T. schoenleinii, T. tonsurans, M. gypseum, T. verrucosum and T. mentagrophytes were isolated in 34%, 10%, 9%, 3%, 3% and 3% of patients, respectively. Of the isolates 94% were susceptible to griseofulvin, and 100% were susceptible to fluconazole. By using griseofulvin for 6–8 weeks 97.4% of the patients were cured; nonresponders required therapy with fluconazole for cure. To conclude, tinea capitis is still a disease of younger people of poor socioeconomic status. T. violaceum and M. audouinii are the most common responsible dermatophytes. The response to griseofulvin was excellent, and it should be used as a first line therapy.

  DOI：

  10.1111/j.1346-8138.2001.tb00081.x

文献信息

• US4217449A
  申请人：——

  公开号：US4217449A

  公开（公告）日：1980-08-12
• Clinico-Mycological Profile of Tinea Capitis in North India and Response to Griseofulvin
  作者：Archana Singal、Sudha Rawat、Sambit Nath Bhattacharya、Sandip Mohanty、Manik Chand Baruah

  DOI：10.1111/j.1346-8138.2001.tb00081.x

  日期：2001.1

  AbstractThere is a paucity of literature on tinea capitis from North India. The response to griseofulvin has not been studied as well. We studied 153 consecutive patients of tinea capitis for clinical patterns, causative dermatophytic species, clinico‐etiological correlation, and response to griseofulvin. Culture and sensitivity were done on all patients. All patients were treated with griseofulvin for 6‐8 weeks; non‐responders were further treated with fluconazole. Ninety percent of the patients were less than 15 years of age, 75% belonged to poor socioeconomic groups and 19% had a family history of tinea capitis. The seborrheic variant was the commonest clinical pattern seen in 47.8% of patients, followed by grey patch, black dot, kerion, and alopecia‐areata‐like tinea capitis in 35.9%, 8.5%, 6.5% and 1.3% of patients, respectively. Only 66% of patients had a positive culture. T. violaceum was the commonest dermatophytic species isolated in 38% patients. M. audouinii, T. schoenleinii, T. tonsurans, M. gypseum, T. verrucosum and T. mentagrophytes were isolated in 34%, 10%, 9%, 3%, 3% and 3% of patients, respectively. Of the isolates 94% were susceptible to griseofulvin, and 100% were susceptible to fluconazole. By using griseofulvin for 6–8 weeks 97.4% of the patients were cured; nonresponders required therapy with fluconazole for cure. To conclude, tinea capitis is still a disease of younger people of poor socioeconomic status. T. violaceum and M. audouinii are the most common responsible dermatophytes. The response to griseofulvin was excellent, and it should be used as a first line therapy.
• Freon; Ser, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1946, vol. 222, p. 447
  作者：Freon、Ser

  DOI：——

  日期：——