cyclohex-1-en-1-ylmethanamine hydrochloride | 34453-11-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: cyclohex-1-en-1-ylmethanamine hydrochloride
• 英文别名: (1-Cyclohexen-1-ylmethyl)amine hydrochloride；cyclohexen-1-ylmethanamine;hydrochloride
• CAS: 34453-11-7
• 化学式: C₇H₁₃N*ClH
• 分子量: 147.648
• InChiKey: PBPGOPRTFZOAES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.87
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 危险性防范说明：
  P264,P280,P302+P352,P337+P313,P305+P351+P338,P362+P364,P332+P313
• 危险性描述：
  H315,H319

反应信息

• 作为反应物：
  描述：

  cyclohex-1-en-1-ylmethanamine hydrochloride 在 四丁基氟化铵 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-((cyclohex-1-en-1-ylmethyl)(ethynyl)amino)-5,5-dimethyl-1,3,2-dioxaphosphinane 2-oxide
  参考文献：
  名称：

  Carbocyclization Cascades of Allyl Ketenimines via Aza-Claisen Rearrangements of N-Phosphoryl-N-allyl-ynamides

  摘要：

  A series of carbocyclization cascades of allyl ketenimines initiated through a thermal aza-Claisen rearrangement of N-phosphoryl-N-allyl ynamides is described. Interceptions of the cationic intermediate via Meerwein-Wagner rearrangements and polyene-type cyclizations en route to fused bi- and tricyclic frameworks are featured.

  DOI：

  10.1021/ol300366e

文献信息

• Synthesis of Cyclic <i>N</i> ‐Hydroxylated Ureas and Oxazolidinone Oximes Enabled by Chemoselective Iodine(III)‐Mediated Radical or Cationic Cyclizations of Unsaturated <i>N</i> ‐Alkoxyureas
  作者：Laure Peilleron、Pascal Retailleau、Kevin Cariou

  DOI：10.1002/adsc.201901135

  日期：2019.11.19

  In this study we describe the reactivity of unsaturated N‐alkoxyureas in the presence of different combinations of a hypervalent iodine(III) reagent and a bromide source or TEMPO. Three complementary cyclizations can be achieved depending on the reaction conditions. On the one hand, PIFA with pyridinium bromide leads to an oxybromination reaction. On the other hand, bis(tert‐butylcarbonyloxy)iodobenzene

  在这项研究中，我们描述了在高价碘（III）试剂和溴化​​物源或TEMPO不同组合存在下不饱和N-烷氧基脲的反应性。取决于反应条件，可以实现三个互补的环化。一方面，PIFA与溴化吡啶鎓导致氧溴化反应。另一方面，双（叔丁基羰氧基）碘苯与四丁基溴化铵或TEMPO分别触发氨基溴化或氨基氧基胺化反应。对照实验表明，这三个反应是通过不同的机理进行的：第一个过程是离子过程，另外两个过程遵循自由基流形。
• Novel Convenient Approach to 6-, 7-, and 8-Numbered Nitrogen Heterocycles Incorporating Endocyclic Sulfonamide Fragment
  作者：Oleksandr Shalimov、Eduard Rusanov、Oksana Muzychka、Petro Onys’ko

  DOI：10.3390/molecules25122887

  日期：——

  A new effective method for the construction of nitrogen heterocycles incorporating endocyclic pharmacophore sulfonamide fragment, based on the use of easy accessible N-(chlorosulfonyl)imidoyl chloride, CCl3C(Cl)=NSO2Cl (1), has been developed. Thus, a reaction of 1 as bielectrophilic 1,3-C–N–S reagent with benzylamines that act as 1,4-N–C–C-C binucleophiles, affords respective 1,2,4-benzothiadiazepine-1

  已经开发了一种新的有效方法，用于构建包含内环药效团磺酰胺片段的氮杂环，该方法基于使用容易获得的 N-（氯磺酰基）亚氨酰氯，CCl3C(Cl)=NSO2Cl (1)。因此，作为双亲电性 1,3-C-N-S 试剂的 1 与作为 1,4-N-C-CC 双亲核试剂的苄胺反应，得到相应的 1,2,4-苯并噻二氮杂-1,1-二氧化物。另一方面，1 与链烯基胺反应，形成各自的 N-链烯基脒，经过路易斯酸引发的分子内环化，得到带有卤甲基的 1,2,4-噻二嗪和 1,2,4-噻二氮唑衍生物。进一步功能化。氯磺酰基在烯基或炔基上亲电杂环化的第一个例子已经被揭示。
• Halocyclization of Unsaturated Guanidines Mediated by Koser’s Reagent and Lithium Halides
  作者：Marion Daniel、Florent Blanchard、Sophie Nocquet-Thibault、Kevin Cariou、Robert H. Dodd

  DOI：10.1021/acs.joc.5b01750

  日期：2015.11.6

  The synthesis of halogenated cyclic guanidines through iodine(III)-mediated umpolung of halide salts is described. Cyclic guanidines of various sizes can be obtained with generally excellent regioselectivities through either a chloro- or a bromocyclization, using Koser’s reagent and the corresponding lithium salt.

  通过碘（III）卤代环状胍的合成介导的极性转换卤化物盐的描述。使用Koser's试剂和相应的锂盐，可以通过氯环化或溴环化获得通常具有出色的区域选择性的各种大小的环状胍。
• AMIDE COMPOUND AND USE THEREOF FOR CONTROLLING PLANT DISEASES
  申请人：Komori Takashi

  公开号：US20100048701A1

  公开（公告）日：2010-02-25

  Disclosed is an amide compound represented by the formula (1) below, which has excellent plant disease controlling activity. In the formula, X 1 represents a fluorine atom or a methoxy group; X 2 represents a hydrogen atom, a halogen atom, a C 1 -C 4 alkyl group or the like; X 3 represents a halogen atom, a C 1 -C 4 alkyl group or the like; Z represents an oxygen atom or a sulfur atom; and A represents an A 1 -CR 11 R 12 R 13 group, an A 2 -Cy 1 group or an A 3 -Cy 2 group, wherein A 1 represents a CH 2 group or the like, A 2 represents a single bond, a CH 2 group or the like, A 3 represents a C 1 -C 3 haloalkyl group, a C 2 -C 4 alkenyl group or the like, Cy 1 represents a C 3 -C 6 cycloalkyl group substituted with a C 1 -C 6 alkoxy group or the like, Cy 2 represents a C 3 -C 6 cycloalkyl group which may be substituted with a halogen atom or the like, R 11 and R 12 independently represent a C 1 -C 4 alkyl group, and R 13 represents a halogen atom, a hydroxyl group or the like.

  本发明揭示了一种由以下式（1）表示的酰胺化合物，该化合物具有优异的植物病害控制活性。在该式中，X1代表氟原子或甲氧基；X2代表氢原子、卤素原子、C1-C4烷基或类似物；X3代表卤素原子、C1-C4烷基或类似物；Z代表氧原子或硫原子；A代表A1-CR11R12R13基团、A2-Cy1基团或A3-Cy2基团，其中A1代表CH2基团或类似物，A2代表单键、CH2基团或类似物，A3代表C1-C3卤代烷基、C2-C4烯基基团或类似物，Cy1代表C3-C6环烷基，其被C1-C6烷氧基或类似物取代，Cy2代表C3-C6环烷基，其可以被卤素原子或类似物取代，R11和R12独立地代表C1-C4烷基，而R13代表卤素原子、羟基或类似物。
• CHEMICAL ADDITIVES AND SURFACTANT COMBINATIONS FOR FAVORABLE WETTABILITY ALTERATION AND IMPROVED HYDROCARBON RECOVERY FACTORS
  申请人：Alchemy Sciences, Inc.

  公开号：US20200131431A1

  公开（公告）日：2020-04-30

  A modified treatment fluid includes a first surfactant, wherein the first surfactant is nonionic, cationic, anionic, zwitterionic, or a combination thereof and a wettability altering additive (WEA) that includes an organic salt, an inorganic salt, urea, a urea derivative, a carbamate, ammonia, an amine, a glycol, a glycol ether, an amide, an aldehyde, or a combination thereof. The modified treatment fluid further includes a treatment fluid.