2-叔丁氧基-n-甲基乙胺 | 1008119-69-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-叔丁氧基-n-甲基乙胺
• 英文名称: {[(1,1-dimethylethyl)oxy]ethyl}methylamine
• 英文别名: [2-(Tert-butoxy)ethyl](methyl)amine；N-methyl-2-[(2-methylpropan-2-yl)oxy]ethanamine
• CAS: 1008119-69-4
• 化学式: C₇H₁₇NO
• mdl: MFCD03453521
• 分子量: 131.218
• InChiKey: RCESGBQILBSYQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-醛基噻吩-4-硼酸频哪醇酯 、 2-叔丁氧基-n-甲基乙胺 、 5-bromo-3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxamide 在 四(三苯基膦)钯 potassium carbonate 、 sodium cyanoborohydride 、 zinc(II) chloride 作用下， 以 1,4-二氧六环 、 水 、 二甲基亚砜 为溶剂， 反应 0.83h， 生成 5-(5-{[{2-[(1,1-dimethylethyl)oxy]ethyl}(methyl)amino]methyl}-3-thienyl)-3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxamide
  参考文献：
  名称：

  WO2008/118724

  摘要：

  公开号：

文献信息

• COMPOUND HAVING READ-THROUGH ACTIVITY
  申请人：THE UNIVERSITY OF TOKYO

  公开号：US20140364642A1

  公开（公告）日：2014-12-11

  [Problem] Provision of a novel compound having read-through activity and a drug for the treatment of nonsense mutation-type disease containing this compound. [Solution] A compound represented by the following general formula (1): and a pharmaceutical composition containing this compound.

  一种具有读穿活性的新化合物以及包含该化合物的用于治疗无义突变型疾病的药物。 一种由以下一般式（1）表示的化合物： 以及含有该化合物的药物组合物。
• SUBSTITUTED THIOPHENYL URACILS, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS
  申请人：Syngenta Crop Protection AG

  公开号：US20200315174A1

  公开（公告）日：2020-10-08

  The invention relates to substituted thiophenyl uracils of general formula (I) or the salts (I) thereof, wherein the groups in general formula (I) are as defined in the description, and to the use thereof as herbicides, in particular for controlling weeds and/or weed grasses in crops of cultivated plants and/or as plant growth regulators for influencing the growth of crops of cultivated plants.

  本发明涉及取代噻吩基尿嘧啶的通式(I)或其盐(I)，其中通式(I)中的基团如描述中定义，以及作为除草剂，特别是用于控制作物中的杂草和/或杂草草本的用途，以及作为植物生长调节剂用于影响栽培植物作物的生长。
• MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE
  申请人：Durand-Reville Thomas

  公开号：US20110021513A1

  公开（公告）日：2011-01-27

  The present invention relates to modulators of IRAK kinase and provides compositions comprising such modulators, as well as methods therewith for treating conditions or diseases mediated by or associated with IRAK kinase.

  本发明涉及IRAK激酶的调节剂，并提供包含这些调节剂的组合物，以及利用这些调节剂治疗由IRAK激酶介导或相关的疾病或病症的方法。
• NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA
  申请人：NOVARTIS AG

  公开号：US20180111932A1

  公开（公告）日：2018-04-26

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R 1 , R 3 -R 6 , X 2 and X 3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了化合物(I)或其药学上可接受的盐；其中R1、R3-R6、X2和X3如本文所定义，一种制造本发明化合物的方法，以及其治疗用途。本发明还提供了药理活性剂的组合和药物组成。
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF MODERATE TO SEVERE PAIN
  申请人：Kandula Mahesh

  公开号：US20150141479A1

  公开（公告）日：2015-05-21

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for treating or preventing or modulating moderate to severe pain in a disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of pain, severe pain, chronic pain, chemotherapy induced pain, epilepsy, glaucoma, arthritis, tooth aches, inflammation, musculoskeletal pain, sciatica, radiculopathy pain, migraine, neuropathic pain, post herpetic neuralgia, neuralgia pain, multiple sclerosis, multiple sclerosis, restless legs syndrome (RLS), cluster headache, depression, fibromyalgia, amyotrophic lateral sclerosis (ALS), convulsions, partial seizures, mood-stabilizing agent and bipolar disorder.

  该发明涉及式I和式II的化合物或其药用盐，以及其多晶体、溶剂合物、对映体、立体异构体和水合物。包含有效量的式I或式II化合物的药物组合物，以及用于治疗、预防或调节疾病中中度至严重疼痛的方法可以制备为口服、颊下、直肠、局部、经皮、经粘膜、静脉、肠道给药、糖浆或注射。这些组合物可用于治疗疼痛、严重疼痛、慢性疼痛、化疗诱导疼痛、癫痫、青光眼、关节炎、牙痛、炎症、肌肉骨骼疼痛、坐骨神经痛、神经根痛、偏头痛、神经性疼痛、带状疱疹后神经痛、神经痛、多发性硬化症、多发性硬化症、不安腿综合症（RLS）、集束性头痛、抑郁症、纤维肌痛、肌萎缩侧索硬化症（ALS）、抽搐、部分性癫痫、情绪稳定剂和躁郁症的药物组合物。